[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611809":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":35,"responsibleParty":320,"collaborators":10,"id":322,"slug":323,"hasResults":324,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":10,"eligibilityCriteria":328,"healthyVolunteers":329,"sex":330,"minAge":10,"maxAge":10,"enrollmentInfo":331,"targetDuration":10,"studyType":334,"phases":10,"briefSummary":335,"conditions":336,"keywords":338,"overallStatus":51,"whyStopped":10,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":344,"completionDateStruct":346,"leadSponsor":348,"locationsCount":349},{"fullName":5,"class":6},"AstraZeneca","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy control cohort",null,"Healthy controls will include at least 20 healthy participants aged 30 years or older, with no clinically significant lung disease or chronic lung disease.",[13],"Other: Participant Follow-up",{"label":15,"type":10,"description":16,"interventionNames":17},"Bronchiectasis cohort","A total of up to 300 NCFBE patients (males and females aged 18 years or older) will be recruited and enrolled into the study. Patient numbers are mainly based on feasible situation.\n\nApproximately 30% of NCFBE patients in the study will be required to have had at least 2 exacerbations in the past 12 months.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"OTHER","Participant Follow-up","This is a longitudinal multi-center, observational, translational study which includes patients with a physician diagnosis of NCFBE by chest HRCT and healthy controls (at baseline only).\n\nThis study will consist of a baseline visit, a 6-month (site visit or telephone visit) and a 12-month visit as well as planned unscheduled visits for exacerbation events and one optional visit for bronchoscopy.Healthy participants will be only enrolled in the baseline visit and bronchoscopy visit.",[15,9],[25],{"name":26,"affiliation":27,"role":28},"Jinfu Xu, Doctor","Shanghai Tongji Hospital, Tongji University School of Medicine","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"AstraZeneca Clinical Study Information Center","CONTACT","1-877-240-9479","information.center@astrazeneca.com",[36,49,55,60,69,78,87,96,104,113,122,131,136,140,149,158,167,176,185,194,199,204,209,214,219,224,233,238,243,252,260,269,277,285,290,298,307,312],{"facility":37,"status":38,"city":39,"state":40,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":10},"Beijing Chaoyang Hospital Affiliated to Capital Medical University","ACTIVE_NOT_RECRUITING","Beijing","Beijing Municipality","China","CN",{"type":44,"coordinates":45},"Point",[46,47],116.39723,39.9075,{"lat":47,"lon":46},{"facility":50,"status":51,"city":39,"state":40,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":52,"geoPoint":54,"contacts":10},"Beijing Hospital","RECRUITING",{"type":44,"coordinates":53},[46,47],{"lat":47,"lon":46},{"facility":56,"status":38,"city":39,"state":40,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":57,"geoPoint":59,"contacts":10},"Peking University People's Hospital",{"type":44,"coordinates":58},[46,47],{"lat":47,"lon":46},{"facility":61,"status":51,"city":62,"state":63,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":64,"geoPoint":68,"contacts":10},"The Second Affiliated Hospital of Chongqing Medical University","Chongqing","Chongqing Municipality",{"type":44,"coordinates":65},[66,67],106.55771,29.56026,{"lat":67,"lon":66},{"facility":70,"status":51,"city":71,"state":72,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":73,"geoPoint":77,"contacts":10},"The Second Affiliated Hospital of Fujian Medical University","Quanzhou","Fujian",{"type":44,"coordinates":74},[75,76],118.58583,24.91389,{"lat":76,"lon":75},{"facility":79,"status":38,"city":80,"state":81,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":82,"geoPoint":86,"contacts":10},"Gansu Provincial Hospital","Lanzhou","Gansu",{"type":44,"coordinates":83},[84,85],103.83987,36.05701,{"lat":85,"lon":84},{"facility":88,"status":38,"city":89,"state":90,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":91,"geoPoint":95,"contacts":10},"Shenzhen People's Hospital","Shenzhen","Guangdong",{"type":44,"coordinates":92},[93,94],114.0683,22.54554,{"lat":94,"lon":93},{"facility":97,"status":51,"city":98,"state":90,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":99,"geoPoint":103,"contacts":10},"Affiliated Hospital of Guangdong Medical University\"","Zhanjiang",{"type":44,"coordinates":100},[101,102],110.38749,21.23391,{"lat":102,"lon":101},{"facility":105,"status":51,"city":106,"state":107,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":108,"geoPoint":112,"contacts":10},"The First Affiliated Hospital of Guangxi Medical University","Nanning","Guangxi",{"type":44,"coordinates":109},[110,111],108.31667,22.81667,{"lat":111,"lon":110},{"facility":114,"status":51,"city":115,"state":116,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":117,"geoPoint":121,"contacts":10},"Guizhou Provincial People's Hospital","Guiyang","Guizhou",{"type":44,"coordinates":118},[119,120],106.71667,26.58333,{"lat":120,"lon":119},{"facility":123,"status":51,"city":124,"state":125,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":126,"geoPoint":130,"contacts":10},"Henan Provincial People's Hospital","Zhengzhou","Henan",{"type":44,"coordinates":127},[128,129],113.64861,34.75778,{"lat":129,"lon":128},{"facility":132,"status":51,"city":124,"state":125,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":133,"geoPoint":135,"contacts":10},"Zhengzhou People's Hospital",{"type":44,"coordinates":134},[128,129],{"lat":129,"lon":128},{"facility":137,"status":51,"city":138,"state":139,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":10,"geoPoint":10,"contacts":10},"Shiyan Taihe Hospital","Shiya","Hubei",{"facility":141,"status":38,"city":142,"state":143,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":144,"geoPoint":148,"contacts":10},"Xiangya Hospital of Central South University","Changsha","Hunan",{"type":44,"coordinates":145},[146,147],112.97087,28.19874,{"lat":147,"lon":146},{"facility":150,"status":38,"city":151,"state":152,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":153,"geoPoint":157,"contacts":10},"The Affiliated Hospital of Xuzhou Medical University","Xuzhou","Jiangsu",{"type":44,"coordinates":154},[155,156],117.28386,34.20442,{"lat":156,"lon":155},{"facility":159,"status":51,"city":160,"state":161,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":162,"geoPoint":166,"contacts":10},"The First Affiliated Hospital of Nanchang University","Nanchang","Jiangxi",{"type":44,"coordinates":163},[164,165],115.85306,28.68396,{"lat":165,"lon":164},{"facility":168,"status":38,"city":169,"state":170,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":171,"geoPoint":175,"contacts":10},"The Second Hospital of Jilin University","Changchun","Jilin",{"type":44,"coordinates":172},[173,174],125.32278,43.88,{"lat":174,"lon":173},{"facility":177,"status":51,"city":178,"state":179,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":180,"geoPoint":184,"contacts":10},"Weifang People's Hospital","Weifang","Shandong",{"type":44,"coordinates":181},[182,183],119.10194,36.71,{"lat":183,"lon":182},{"facility":186,"status":51,"city":187,"state":188,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":189,"geoPoint":193,"contacts":10},"Huadong Hospital Affiliated to Fudan University","Shanghai","Shanghai Municipality",{"type":44,"coordinates":190},[191,192],121.45806,31.22222,{"lat":192,"lon":191},{"facility":195,"status":38,"city":187,"state":188,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":196,"geoPoint":198,"contacts":10},"Ruijin Hospital, Shanghai Jiao Tong University School of Medicine",{"type":44,"coordinates":197},[191,192],{"lat":192,"lon":191},{"facility":200,"status":51,"city":187,"state":188,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":201,"geoPoint":203,"contacts":10},"Shanghai Fifth People's Hospital",{"type":44,"coordinates":202},[191,192],{"lat":192,"lon":191},{"facility":205,"status":38,"city":187,"state":188,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":206,"geoPoint":208,"contacts":10},"Shanghai General Hospital",{"type":44,"coordinates":207},[191,192],{"lat":192,"lon":191},{"facility":210,"status":38,"city":187,"state":188,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":211,"geoPoint":213,"contacts":10},"Shanghai Pulmonary Hospital",{"type":44,"coordinates":212},[191,192],{"lat":192,"lon":191},{"facility":215,"status":51,"city":187,"state":188,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":216,"geoPoint":218,"contacts":10},"Shanghai Tongji Hospital",{"type":44,"coordinates":217},[191,192],{"lat":192,"lon":191},{"facility":220,"status":38,"city":187,"state":188,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":221,"geoPoint":223,"contacts":10},"Zhongshan Hospital Affiliated to FuDan University\"",{"type":44,"coordinates":222},[191,192],{"lat":192,"lon":191},{"facility":225,"status":51,"city":226,"state":227,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":228,"geoPoint":232,"contacts":10},"Chengdu Fifth People's Hospital","Chengdu","Sichuan",{"type":44,"coordinates":229},[230,231],104.06667,30.66667,{"lat":231,"lon":230},{"facility":234,"status":51,"city":226,"state":227,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":235,"geoPoint":237,"contacts":10},"Sichuan Academy of Medical Sciences · Sichuan Provincial People's Hospital",{"type":44,"coordinates":236},[230,231],{"lat":231,"lon":230},{"facility":239,"status":51,"city":226,"state":227,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":240,"geoPoint":242,"contacts":10},"West China Hospital of Sichuan University",{"type":44,"coordinates":241},[230,231],{"lat":231,"lon":230},{"facility":244,"status":38,"city":245,"state":246,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":247,"geoPoint":251,"contacts":10},"Anning First People's Hospital","Anning","Yunnan",{"type":44,"coordinates":248},[249,250],102.48496,24.92271,{"lat":250,"lon":249},{"facility":253,"status":38,"city":254,"state":246,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":255,"geoPoint":259,"contacts":10},"The First Affiliated Hospital of Kunming Medical University","Kunming",{"type":44,"coordinates":256},[257,258],102.71833,25.03889,{"lat":258,"lon":257},{"facility":261,"status":38,"city":262,"state":263,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":264,"geoPoint":268,"contacts":10},"The Second Affiliated Hospital of Zhejiang University School of Medicine","Hangzhou","Zhejiang",{"type":44,"coordinates":265},[266,267],120.16142,30.29365,{"lat":267,"lon":266},{"facility":270,"status":38,"city":271,"state":263,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":272,"geoPoint":276,"contacts":10},"Jiaxing Second Hospital","Jiaxing",{"type":44,"coordinates":273},[274,275],120.75,30.7522,{"lat":275,"lon":274},{"facility":278,"status":51,"city":279,"state":263,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":280,"geoPoint":284,"contacts":10},"Ningbo Fenghua District People's Hospital","Ningbo",{"type":44,"coordinates":281},[282,283],121.54945,29.87819,{"lat":283,"lon":282},{"facility":286,"status":38,"city":279,"state":263,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":287,"geoPoint":289,"contacts":10},"The First Affiliated Hospital of Ningbo University",{"type":44,"coordinates":288},[282,283],{"lat":283,"lon":282},{"facility":291,"status":51,"city":292,"state":263,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":293,"geoPoint":297,"contacts":10},"The First Affiliated Hospital of Wenzhou Medical University","Wenzhou",{"type":44,"coordinates":294},[295,296],120.66682,27.99942,{"lat":296,"lon":295},{"facility":299,"status":38,"city":300,"state":301,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":302,"geoPoint":306,"contacts":10},"Huzhou Central Hospital","Huzhou","Zhejing",{"type":44,"coordinates":303},[304,305],120.0933,30.8703,{"lat":305,"lon":304},{"facility":308,"status":38,"city":271,"state":301,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":309,"geoPoint":311,"contacts":10},"Jiaxing First Hospital",{"type":44,"coordinates":310},[274,275],{"lat":275,"lon":274},{"facility":313,"status":51,"city":314,"state":124,"zip":10,"country":41,"countryCode":42,"cosmosGeoPoint":315,"geoPoint":319,"contacts":10},"The First Affiliated Hospital of Xinxiang Medical University","Xinxiang",{"type":44,"coordinates":316},[317,318],113.80151,35.19033,{"lat":318,"lon":317},{"type":321,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100611809","a-translational-study-for-phenotyping-and-endotyping-chinese-patients-with-ncfbe-100611809",false,"NCT07245407","A Translational Study for Phenotyping and Endotyping Chinese Patients With NCFBE","A Multi-center Longitudinal Observation Translational Study to Evaluate Phenotypes, Endotypes and Biomarkers in Chinese Patients With NCFBE","Inclusion Criteria:\n\nHealthy control cohort:\n\n· Age ≥30 years\n\nBronchiectasis cohort:\n\n* Capable of giving signed informed consent.\n* Participant must be ≥18 years of age, at the time of signing the ICF.\n* Able to perform acceptable lung function testing according to ATS\u002FERS 2019 acceptability criteria.\n* Able and willing to comply with the requirements of the protocol including ability to read, write, be fluent in the translated language of all participants facing questionnaires used at center, and use electronic devices (e.g. FENO and spirometry).\n* Documented physician-diagnosed bronchiectasis: with a clinical history consistent with bronchiectasis (chronic cough and daily sputum production etc.) and having performed chest HRCT indicating bronchiectasis.\n* Remaining clinically stable upon recruitment. Patients with exacerbations are allowed to be enrolled into the study at least 4 weeks after the end of exacerbations. If a patient experiencing exacerbation and directly enters the exacerbation visit, the patient is required to come to the study site for baseline visit (after confirming that all inclusion\u002Fexclusion criteria are met) within 4 weeks \u002F+ 3 days after the end of exacerbation\n\nExclusion Criteria:\n\nHealthy control cohort:\n\n* Any respiratory diagnosis (asthma, COPD, bronchiectasis, pulmonary fibrosis or any other chronic respiratory condition requiring regular treatment).\n* Inflammatory conditions including rheumatoid arthritis, inflammatory bowel disease, any other connective tissue disease.\n* Active malignancy excluding non-melanoma skin cancer.\n* Antibiotic treatment for an acute respiratory tract infection in the previous 4 weeks or current sinusitis.\n* Any contraindication to study procedures including bronchoscopy.\n* Current smoking or smoking in the preceding 3 months.\n* Treatment with anti-coagulants.\n\nBronchiectasis cohort:\n\n* Traction bronchiectasis associated with interstitial lung disease or other pulmonary disorders (e.g., pulmonary fibrosis and cystic fibrosis).\n* Primary diagnosis of another pulmonary condition, including COPD, asthma. Patients with a secondary diagnosis of these pulmonary diseases will be allowed to participate as long as bronchiectasis is considered by the investigator to be the primary diagnosis.\n* Any disorder, including, but not limited to, cardiovascular, gastrointestinal, hepatic, renal, neurological, musculoskeletal, infectious, endocrine, metabolic, hematological, psychiatric, or major physical impairment that is not stable in the opinion of the investigator and could:\n* Affect the safety of the participant throughout the study\n* Influence the findings of the study or the interpretation\n* Impede the participant's ability to complete the entire duration of study\n* The participant has a history of alcohol or drug abuse within the past year, which, in the opinion of the responsible physician, contra-indicates their participation.\n* Active malignancy excluding non-melanoma skin cancer.\n* Participants is female who is pregnant or lactating or up to 6 weeks post-partum or 6 weeks cessation of breastfeeding.\n* The participant has an altered mental status at the time of informed consent.\n* History or current evidence of an upper or lower respiratory infection or symptoms(including common cold) within 2 weeks of baseline assessments\n* Involvement in the planning and\u002For conduct of the study (applies to both AstraZeneca staff and\u002For staff at the study center).\n* Terminal disease and\u002For organ failure or participants otherwise considered not appropriate for the study participation.",true,"ALL",{"count":332,"type":333},320,"ESTIMATED","OBSERVATIONAL","Non-cystic fibrosis bronchiectasis (NCFBE) is a chronic respiratory disease characterized by a clinical syndrome of chronic productive cough and recurrent respiratory infections in the presence of abnormal and permanent dilation of the bronchi. Recent epidemiological studies have clearly shown that the prevalence and incidence of NCFBE are quickly rising both in high- and low-income countries. With the increase of prevalence, bronchiectasis brings huge medical and economic burden to the society.\n\nIn this study, the investigator will perform biomarker assessments and multi-omics analysis on NCFBE patients and healthy participants in China to validate the link of disease pathways to pathophysiological features and uncover the molecular endotypes behind clinical phenotypesof Chinese patients with NCFBE.",[337],"Non-cystic Fibrosis Bronchiectasis",[339],"NCFBE","2026-06-15",{"date":342,"type":343},"2026-06-16","ACTUAL",{"date":345,"type":343},"2025-10-27",{"date":347,"type":333},"2027-07-29",{"name":5,"class":6},38]