[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588378":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":28,"centralContacts":32,"locations":41,"responsibleParty":64,"collaborators":24,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":24,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":95,"overallStatus":43,"whyStopped":24,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"University of Texas Southwestern Medical Center","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"D-mannose","ACTIVE_COMPARATOR","Dietary Supplement: D-Mannose",[11],{"label":14,"type":15,"description":16,"interventionNames":17},"Placebo","PLACEBO_COMPARATOR","Dietary Supplement: Placebo",[16],[19,25],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIETARY_SUPPLEMENT","D-Mannose","D-mannose (2g, i.e., 4 x 500mg capsules) daily for 12 months.",[9],null,{"type":20,"name":14,"description":26,"armGroupLabels":27,"otherNames":24},"Placebo daily for 12 months.",[14],[29],{"name":30,"affiliation":5,"role":31},"Philippe Zimmern, MD","PRINCIPAL_INVESTIGATOR",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":24,"email":37},"Jessica de Araujo Paula","CONTACT","2146458787","jessica.dearaujopaula@utsouthwestern.edu",{"name":39,"role":35,"phone":36,"phoneExt":24,"email":40},"Meghan Leak","meghan.leak@utsouthwestern.edu",[42],{"facility":5,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Dallas","Texas","75390","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-96.80667,32.78306,{"lat":53,"lon":52},[56,60,62],{"name":57,"role":35,"phone":58,"phoneExt":24,"email":59},"Sonobia Garrett, BSHS","214-645-8787","sonobia.garrett@utsouthwestern.edu",{"name":24,"role":35,"phone":24,"phoneExt":24,"email":61},"philippe.zimmern@utsouthwestern.edu",{"name":63,"role":31,"phone":24,"phoneExt":24,"email":24},"Philippe E Zimmern, MD",{"type":31,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Philippe Zimmern","Professor","100588378","a-trial-of-d-mannose-for-the-prophylaxis-of-recurrent-urinary-tract-infections-100588378",false,"NCT06940622","A Trial of D-mannose for the Prophylaxis of Recurrent Urinary Tract Infections","A Randomized Controlled Trial of D-mannose for the Prophylaxis of Recurrent Urinary Tract Infections in Post-menopausal Women","DmannoseRCT","Inclusion Criteria:\n\n* Female, post-menopausal, age ≥ 55 years old\n* Diagnosis of recurrent UTI, defined as ≥ 3 symptomatic culture-proven UTI episodes in 12 months or ≥ 2 in 6 months.\n* Currently free from a UTI determined based on absence of symptoms as determined by the UTI symptom assessment questionnaire79 and negative urine culture (\\\u003C103 colony forming units per ml of urine).\n* Able to attend all follow-up appointments for the study.\n* A negative upper and lower urinary tract evaluation, including pelvic examination for pelvic organ prolapse (less than stage 2), measurement of post-void residual (less than 50 ml), and imaging (renal ultrasound and standing voiding cystourethrogram) to exclude kidney stone, hydronephrosis, reflux, or urethral diverticulum.\n\nExclusion Criteria:\n\n* Current use of D-mannose. Patients willing to stop taking D-mannose will be offered to join the trial after a 4-week wash-out period.\n* Complicated UTIs, including need for catheter drainage or intermittent catheterization, neurogenic bladder, bladder augmentation, or urinary diversion.\n* Ongoing supplement use (Box 1). Patients willing to stop taking the listed supplements will be offered to join the trial after a 4-week wash-out period.\n* Evidence of upper tract infection (pyelonephritis), including temperature higher than 38°C, flank\u002Flumbar pain or tenderness\n* Diagnosis of interstitial cystitis or overactive bladder syndrome\n* Prophylactic antibiotics started in the last 3 months and unwilling to discontinue, or intention to start in the next 12 months\n* Use of Uromune or other vaccine approaches to reduce rUTI\n* Participation in a research study involving an investigational product in the past 12 weeks\n* Receipt of phage treatment\n* History of chronic diarrhea requiring regular therapy\n* Inability to swallow or known history of gastrointestinal malabsorption\n* History of recurrent vaginal yeast infections\n* Systemic disease precluding enrollment in this study (uncontrolled diabetes with HgA1C above 7, ongoing chemotherapy or immunotherapy, renal insufficiency \\[creatinine \\> 1.5 g\u002Fdl\\]), mental or cognitive impairment, weight loss diet requiring excessively large amounts of fluid intake, or other health-related specific diet).\n* Nursing home resident\n* BMI \\>40\n\nBox 1 Supplements to avoid\n\n* Multi-Vitamins and Multi-Mineral capsules\n* Specific Vitamins or Minerals (e.g., Calcium, Citrical, Calcium Gummies, Vitamin A, D, Niacin, Pyridoxine, Selenium, Vitamin E, B6, Iron, Omega 3, D3, Magnesium, B-Complex, Women's Ultra MultiVitamin, GNC B-Complex, B-12, PreserVision Areds2, Vitamins D, B Pollen)\n* Probiotics\n* Cranberry Mannose or Cranberry Extract Weight loss products to avoid\n* Medifast\n* Vitafusion\n* OptiVin Products\n* Appetite Suppressants\n* Keto-Fuel","FEMALE","55 Years","85 Years",{"count":79,"type":80},90,"ESTIMATED","INTERVENTIONAL",[83],"NA","A randomized, double-blind, placebo-controlled, 12-month study to determine the effectiveness of D-mannose (2g daily) supplementation in rUTI (recurrent urinary tract infection) prevention in post-menopausal women.",[86,87,88,89,90,91,92,93,94],"Recurrent UTIs","Recurrent Urinary Tract Infections","Recurrent Urinary Tract Infections in Women","Recurrent Urinary Tract Infection","Cystitis Recurrent","Cystitis Chronic","UTI","UTI - Urinary Tract Infection","UTI - Lower Urinary Tract Infection",[9,96,97,98,99,100,101,102,103],"dmannose","uti","ruti","recurrent urinary tract infection","urinary tract infection","cystitis","chronic uti","chronic cystitis","2025-09-18",{"date":106,"type":107},"2025-09-22","ACTUAL",{"date":109,"type":107},"2025-08-01",{"date":111,"type":80},"2030-09-30",{"name":5,"class":6},1]