[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100541087":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":45,"responsibleParty":255,"collaborators":259,"id":267,"slug":268,"hasResults":269,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":273,"eligibilityCriteria":274,"healthyVolunteers":269,"sex":275,"minAge":276,"maxAge":277,"enrollmentInfo":278,"targetDuration":26,"studyType":281,"phases":282,"briefSummary":284,"conditions":285,"keywords":289,"overallStatus":62,"whyStopped":26,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":302,"completionDateStruct":304,"leadSponsor":306,"locationsCount":307},{"fullName":5,"class":6},"University Children's Hospital, Zurich","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"IMP arm","ACTIVE_COMPARATOR","Azithromycin Pfizer® powder for oral suspension:\n\n1 daily dose for 5 days, 10mg\u002Fkg\u002Fday on day 1 and 5mg\u002Fkg\u002Fday on days 2-5",[13],"Drug: Azithromycin Pfizer®",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo arm","PLACEBO_COMPARATOR","5 days of placebo",[19],"Drug: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Azithromycin Pfizer®","Azithromycin Pfizer® powder for oral suspension will be used in the active comparator arm: 1 daily dose for 5 days, 10mg\u002Fkg\u002Fday on day 1 and 5mg\u002Fkg\u002Fday on days 2-5",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","Control comparator arm: 5 days of placebo",[15],[32],{"name":33,"affiliation":5,"role":34},"Christoph Berger, Prof. Dr. med.","STUDY_CHAIR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Patrick M Meyer Sauteur, PD Dr. Dr. med.","CONTACT","0041 44 266 78 96","patrick.meyersauteur@kispi.uzh.ch",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Margarete Von Wantoch, Dr. rer. nat.","0041 044 266 38 32","Margarete.VonWantoch@kispi.uzh.ch",[46,60,81,99,116,132,148,164,180,196,211,223,239],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":26},"Children's Hospital Aarau, Switzerland","ACTIVE_NOT_RECRUITING","Aarau","Canton of Aargau","5001","Switzerland","CH",{"type":55,"coordinates":56},"Point",[57,58],8.04422,47.39254,{"lat":58,"lon":57},{"facility":61,"status":62,"city":63,"state":64,"zip":65,"country":52,"countryCode":53,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"University of Basel Children's Hospital, Switzerland","RECRUITING","Basel","Canton of Basel-City","4056",{"type":55,"coordinates":67},[68,69],7.57327,47.55839,{"lat":69,"lon":68},[72,76,78],{"name":73,"role":38,"phone":74,"phoneExt":26,"email":75},"Julia A Bielicki, PD Dr. Dr. med.","0041 61 704 12 12","julia.bielicki@ukbb.ch",{"name":73,"role":77,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"name":79,"role":80,"phone":26,"phoneExt":26,"email":26},"Ulrich Heiniger, Prof. Dr. med.","SUB_INVESTIGATOR",{"facility":82,"status":62,"city":83,"state":84,"zip":85,"country":52,"countryCode":53,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"University Children's Hospital Bern, Switzerland","Bern","Canton of Bern","3010",{"type":55,"coordinates":87},[88,89],7.44744,46.94809,{"lat":89,"lon":88},[92,96,97],{"name":93,"role":38,"phone":94,"phoneExt":26,"email":95},"Philipp Agyeman, PD Dr. med.","0041 31 632 21 11","Philipp.Agyeman@insel.ch",{"name":93,"role":77,"phone":26,"phoneExt":26,"email":26},{"name":98,"role":80,"phone":26,"phoneExt":26,"email":26},"Kristina Keitel, PD Dr. Dr. med.",{"facility":100,"status":101,"city":102,"state":103,"zip":104,"country":52,"countryCode":53,"cosmosGeoPoint":105,"geoPoint":109,"contacts":110},"Department of Pediatrics, Fribourg Hospital, Switzerland","NOT_YET_RECRUITING","Fribourg","Canton of Fribourg","1708",{"type":55,"coordinates":106},[107,108],7.15128,46.80237,{"lat":108,"lon":107},[111,115],{"name":112,"role":38,"phone":113,"phoneExt":26,"email":114},"Petra Zimmermann, PD Dr. Dr. med.","0041 26 306 00 00","petra.zimmermann@unifr.ch",{"name":112,"role":77,"phone":26,"phoneExt":26,"email":26},{"facility":117,"status":101,"city":118,"state":119,"zip":120,"country":52,"countryCode":53,"cosmosGeoPoint":121,"geoPoint":125,"contacts":126},"Children's Hospital of Geneva, University Hospitals of Geneva, Switzerland","Geneva","Canton of Geneva","1205",{"type":55,"coordinates":122},[123,124],6.14569,46.20222,{"lat":124,"lon":123},[127,131],{"name":128,"role":38,"phone":129,"phoneExt":26,"email":130},"Noémie Wagner, Dr. med.","0041 22 372 40 00","Noemie.Wagner@hcuge.ch",{"name":128,"role":77,"phone":26,"phoneExt":26,"email":26},{"facility":133,"status":62,"city":134,"state":135,"zip":136,"country":52,"countryCode":53,"cosmosGeoPoint":137,"geoPoint":141,"contacts":142},"Children's Hospital of Central Switzerland, Switzerland","Lucerne","Canton of Lucerne","6000",{"type":55,"coordinates":138},[139,140],8.30635,47.05048,{"lat":140,"lon":139},[143,147],{"name":144,"role":38,"phone":145,"phoneExt":26,"email":146},"Alex Donas, Dr. med.","0041 41 205 31 66","alex.donas@luks.ch",{"name":144,"role":77,"phone":26,"phoneExt":26,"email":26},{"facility":149,"status":62,"city":150,"state":151,"zip":152,"country":52,"countryCode":53,"cosmosGeoPoint":153,"geoPoint":157,"contacts":158},"Children's Hospital of Eastern Switzerland St. Gallen","Sankt Gallen","Canton of St. Gallen","9006",{"type":55,"coordinates":154},[155,156],9.37477,47.42391,{"lat":156,"lon":155},[159,163],{"name":160,"role":38,"phone":161,"phoneExt":26,"email":162},"Anita Niederer-Loher, Dr. med.","0041 71 243 71 11","anita.niederer@kispisg.ch",{"name":160,"role":77,"phone":26,"phoneExt":26,"email":26},{"facility":165,"status":101,"city":166,"state":167,"zip":168,"country":52,"countryCode":53,"cosmosGeoPoint":169,"geoPoint":173,"contacts":174},"Department of Pediatrics, Department Mother-Woman-Child, Lausanne University Hospital, Switzerland","Lausanne","Canton of Vaud","1011",{"type":55,"coordinates":170},[171,172],6.63282,46.516,{"lat":172,"lon":171},[175,179],{"name":176,"role":38,"phone":177,"phoneExt":26,"email":178},"Ludivine Coulon, Dr. med.","0041 21 314 11 11","Ludivine.Coulon@chuv.ch",{"name":176,"role":77,"phone":26,"phoneExt":26,"email":26},{"facility":181,"status":62,"city":182,"state":183,"zip":184,"country":52,"countryCode":53,"cosmosGeoPoint":185,"geoPoint":189,"contacts":190},"Department of Pediatrics, Cantonal Hospital Winterthur, Switzerland","Winterthur","Canton of Zurich","8401",{"type":55,"coordinates":186},[187,188],8.72413,47.50564,{"lat":188,"lon":187},[191,195],{"name":192,"role":38,"phone":193,"phoneExt":26,"email":194},"Andreas Jung, Dr. med.","0041 52 266 41 44","andreas.jung@ksw.ch",{"name":192,"role":77,"phone":26,"phoneExt":26,"email":26},{"facility":197,"status":62,"city":198,"state":183,"zip":199,"country":52,"countryCode":53,"cosmosGeoPoint":200,"geoPoint":204,"contacts":205},"University Children's Hospital Zurich, Switzerland","Zurich","8032",{"type":55,"coordinates":201},[202,203],8.55,47.36667,{"lat":203,"lon":202},[206,210],{"name":207,"role":38,"phone":208,"phoneExt":26,"email":209},"Michelle Seiler, PD Dr. med","0041 44 266 71 11","Michelle.Seiler@kispi.uzh.ch",{"name":207,"role":77,"phone":26,"phoneExt":26,"email":26},{"facility":212,"status":101,"city":198,"state":183,"zip":213,"country":52,"countryCode":53,"cosmosGeoPoint":214,"geoPoint":216,"contacts":217},"Department of Pediatrics, Triemli Hospital Zurich, Switzerland","8063",{"type":55,"coordinates":215},[202,203],{"lat":203,"lon":202},[218,222],{"name":219,"role":38,"phone":220,"phoneExt":26,"email":221},"Maren Tomaske, Prof. Dr. med.","0041 44 416 11 11","Maren.Tomaske@stadtspital.ch",{"name":219,"role":77,"phone":26,"phoneExt":26,"email":26},{"facility":224,"status":101,"city":225,"state":226,"zip":227,"country":52,"countryCode":53,"cosmosGeoPoint":228,"geoPoint":232,"contacts":233},"Institute of Pediatrics of Southern Switzerland, EOC, Bellinzona, Switzerland","Bellinzona","Canton Ticino","6500",{"type":55,"coordinates":229},[230,231],9.01703,46.19278,{"lat":231,"lon":230},[234,238],{"name":235,"role":38,"phone":236,"phoneExt":26,"email":237},"Lisa Kottanattu, Dr. med.","0041 91 811 91 11","Lisa.Kottanattu@eoc.ch",{"name":235,"role":77,"phone":26,"phoneExt":26,"email":26},{"facility":240,"status":62,"city":241,"state":242,"zip":243,"country":52,"countryCode":53,"cosmosGeoPoint":244,"geoPoint":248,"contacts":249},"Department of Pediatrics, Cantonal Hospital Graubuenden, Switzerland","Chur","Kanton Graubünden","7000",{"type":55,"coordinates":245},[246,247],9.53287,46.84986,{"lat":247,"lon":246},[250,254],{"name":251,"role":38,"phone":252,"phoneExt":26,"email":253},"Beate Deubzer, Dr. med.","0041 81 256 61 11","beate.deubzer@ksgr.ch",{"name":251,"role":77,"phone":26,"phoneExt":26,"email":26},{"type":256,"investigatorFullName":257,"investigatorTitle":258,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Christoph Berger","Prof. Dr. med.",[260,262,265],{"name":261,"class":6},"Swiss National Science Foundation",{"name":263,"class":264},"Swiss Clinical Trial Organisation","UNKNOWN",{"name":266,"class":6},"SwissPedNet","100541087","a-trial-of-placebo-versus-macrolide-for-mycoplasma-pneumoniae-childhood-pneumonia-mythic-study-100541087",false,"NCT06325293","A Trial of Placebo Versus Macrolide for Mycoplasma Pneumoniae Childhood Pneumonia: MYTHIC Study","A Randomized Controlled Non-inferiority Trial of Placebo Versus Macrolide Antibiotics for Mycoplasma Pneumoniae Infection in Children With Community-acquired Pneumonia - the MYTHIC Study","MYTHIC","Inclusion criteria for screening phase:\n\n* Children aged 3-17 years (from 3rd up to 18th birthday) presenting to the emergency department (ED) who will be managed ambulatory or will be admitted to general ward.\n* Clinical diagnosis of CAP:\n\n  1. Diagnosis defined as the treating physician's documented diagnosis of CAP; AND\n  2. Fever ≥38.0°C (measured by any method \\[i.e., ear, axillary, rectal, or forehead site\\] in the ED or via parent report observed in the last 24h); AND\n  3. Tachypnea (defined as respiratory rate (RR) above age-specific reference value) during the assessment in ED (triage or clinical examination).\n* Written screening consent for participation in screening phase signed by parents\u002Flegal guardians and the patient if ≥14 years of age.\n\nAdditional inclusion criteria for intervention phase:\n\n* Positive Mp screening test result with the Mp IgM lateral flow assay (LFA) (grade 2 or 3).\n* Written informed consent for participation in intervention phase signed by parents or legal guardians and the patient if ≥14 years of age.\n\nExclusion criteria:\n\nExclusion criteria for screening phase:\n\n• None.\n\nExclusion criteria for intervention phase:\n\n* Contraindication to azithromycin: Documented allergy to azithromycin; cardiovascular disease, including bradycardia, arrhythmias, and\u002For QT-interval prolongation\\*; myasthenia gravis.\n\n  \\*Co-medication with arrhythmogenic or QT-interval-prolonging drug (www.qtdrugs.org) is no exclusion criteria but will be discussed with the local investigators and\u002For trial management team (TMT).\n* Underlying comorbidities: Cystic fibrosis or other chronic lung disorders (excluding asthma), primary or secondary immunodeficiency, sickle-cell anemia, or severe cerebral palsy.\n* History of recurrent pneumonia (two or more episodes) or severe pneumonia (ICU admission or complications of CAP such as lung abscess, effusion, and empyema) in lifetime.\n* Antibiotic treatment against Mp within the previous 7 days, including macrolides, tetracyclines, or fluoroquinolones.\n* Referral to ICU directly from the ED.\n* Inability to take oral medication.\n* Parents are unlikely to reliably complete follow up (FUP) visits and questionnaires (e.g., due to language barriers or living far from the study site).","ALL","3 Years","17 Years",{"count":279,"type":280},376,"ESTIMATED","INTERVENTIONAL",[283],"NA","The goal of this clinical trial is to compare a placebo (a look-alike substance that contains no active drug) with a commonly used antibiotic in children with Mycoplasma pneumoniae (a specific bacterium) induced community-acquired pneumonia. The main question it aims to answer is:\n\nIs antibiotic treatment needed in Mycoplasma pneumoniae (a specific bacterium) induced pneumonia?\n\nParticipants will receive either a placebo or a antibiotic treatment and track their symptoms and vital signs until they are healthy.\n\nResearchers will then compare the length of symptoms between the placebo and the antibiotic group.",[286,287,288],"Community Acquired Pneumonia in Children","Mycoplasma Pneumoniae","Mycoplasma Pneumoniae Pneumonia",[290,291,292,293,294,295,296,297],"Mycoplasma pneumoniae","community-acquired pneumonia","randomized controlled trial","Investigator Initiated Clinical Trial (IICT)","Paediatric pneumonia","children","placebo","macrolides","2026-04-29",{"date":300,"type":301},"2026-05-05","ACTUAL",{"date":303,"type":301},"2025-01-28",{"date":305,"type":280},"2028-12-31",{"name":257,"class":6},13]