[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593634":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":25,"locations":34,"responsibleParty":52,"collaborators":54,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":24,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":24,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":37,"whyStopped":24,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Boston College","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Immediate intervention","EXPERIMENTAL","During the first 12 weeks following enrollment, the Immediate Intervention group will engage in daily practice with the HippoCamera app. HippoCamera is a smartphone application that allows participants to record and replay important events in their daily lives. Based on principles from psychology and neuroscience, engaging in this daily practice may increase focus on memory-orientated practices in participants.",[13],"Behavioral: Memory replay",{"label":15,"type":6,"description":16,"interventionNames":17},"Delayed Intervention","During the first 12 weeks following enrollment, the Delayed Intervention group will serve as a control, receiving no intervention. After the initial 12 weeks, they will be entered into daily engagement with the HippoCamera app.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","Memory replay","Within the HippoCamera application, half of all recorded events will be categorized as \"baseline\" memories, and half will be categorized as \"replay\" memories.\n\nBaseline memories are recorded, but never viewed by the participant again until the \"Early HippoCamera\" test at the end of the 12-week intervention.\n\nReplay memories are recorded, and then placed into a memory gallery. HippoCamera uses a research-based algorithm to select 5 memories from this gallery for participants to replay each day. Prior research has shown that this replay is associated with significant memory enhancements for replayed v. baseline memories for HippoCamera users from other populations.",[15,9],null,[26,31],{"name":27,"role":28,"phone":29,"phoneExt":24,"email":30},"Jaclyn Ford, PhD","CONTACT","617-312-4735","jaclyn.ford@bc.edu",{"name":32,"role":28,"phone":33,"phoneExt":24,"email":24},"Lauren Voso, BS","(617) 552-6949",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Boston College ONLINE STUDY","RECRUITING","Chestnut Hill","Massachusetts","02467","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-71.16616,42.33065,{"lat":47,"lon":46},[50],{"name":32,"role":28,"phone":33,"phoneExt":24,"email":51},"canlab@bc.edu",{"type":53,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[55,57],{"name":56,"class":6},"Massachusetts General Hospital",{"name":58,"class":6},"University of Colorado, Denver","100593634","a-virtual-three-month-intervention-study-of-the-effects-of-a-smartphone-application-hippocamera-on-memory-in-teens-and-young-adults-with-down-syndrome-100593634",false,"NCT07008989","A VIRTUAL Three-month Intervention Study of the Effects of a Smartphone Application (HippoCamera) on Memory in Teens and Young Adults With Down Syndrome","Use of a Digital Memory Prosthetic to Support Autobiographical Memory in Down Syndrome","Inclusion Criteria:\n\n* Diagnosis of Down syndrome\n* Daily access to a smart phone\n* The ability to create and replay memories using HippoCamera with limited support from a guardian\n* Informed consent obtained from parent or guardian (or participant, if legally independent)\n* Informed verbal assent obtained from participant\n* Ability to comprehend instructions, denoted by parent\u002Fguardian acknowledgment\n* English as a primary written and spoken language\n* Normal or corrected-to-normal vision and hearing\n* All races\u002Fethnicities and socio-economic statuses\n\nExclusion Criteria:\n\n* Autism\n* Non-native speaker of English (acquired after the age of 5)","ALL","15 Years","35 Years",{"count":70,"type":71},40,"ESTIMATED","INTERVENTIONAL",[74],"NA","Down syndrome is a chromosomal abnormality associated with significant deficits across multiple cognitive domains, including a disproportionate deficit in hippocampally-dependent memory. In other words, individuals with Down syndrome may have a particular difficulty remembering specific details from past events. One way this manifests itself is in overgeneral autobiographical memory, or a tendency to remember the general gist of an event or cluster of events, rather than a single, isolated event. This overgeneral memory makes it difficult for individuals with Down syndrome to access their past, can interfere with attempts to becoming more independent, and increases anxiety and depression.\n\nIn the current VIRTUAL study, the investigators test whether a new digital memory prosthetic-HippoCamera-can enhance specific autobiographical memory in individuals with Down syndrome. In HippoCamera, users are asked to record and replay events from their daily lives. This replay is curated by a research-based algorithm in HippoCamera that optimizes consolidation of these events over time and has been shown to enhance memory specificity in other populations with memory impairments, particularly those that stem from hippocampal disfunction. It is, therefore, likely that similar enhancements in autobiographical memory specificity will be identified in individuals with Down syndrome, highlighting the benefits of this applications in this population.",[77,78],"Memory Replay","HippoCamera",[80,81,82,83],"Down syndrome","memory","hippocampus","technology","2025-06-16",{"date":86,"type":87},"2025-06-19","ACTUAL",{"date":89,"type":87},"2025-06-01",{"date":91,"type":71},"2026-07-31",{"name":5,"class":6},1]