[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613904":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":39,"locations":44,"responsibleParty":46,"collaborators":44,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":44,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":44,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":73,"whyStopped":44,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":44},{"fullName":5,"class":6},"Second Hospital of Jilin University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"AAR\u002FAAR+HAR Group","EXPERIMENTAL","Participants randomized to this group will undergo ascending aorta replacement alone or ascending aorta plus hemiarch replacement (AAR\u002FAAR+HAR), according to the operative strategy. This procedure involves replacing the ascending aorta with or without replacement of the proximal aortic arch while preserving the distal arch and supra-aortic vessels.",[13],"Procedure: Ascending Aorta Replacement \u002F Ascending Aorta Plus Hemiarch Replacement",{"label":15,"type":16,"description":17,"interventionNames":18},"AAR+TAR+FET Group","ACTIVE_COMPARATOR","Participants randomized to this group will undergo ascending aorta replacement with total arch replacement and frozen elephant trunk implantation (AAR+TAR+FET). This procedure involves replacement of the entire aortic arch combined with frozen elephant trunk repair of the proximal descending aorta.",[19],"Procedure: Ascending Aorta Replacement With Total Arch Replacement and Frozen Elephant Trunk",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Ascending Aorta Replacement \u002F Ascending Aorta Plus Hemiarch Replacement","This procedure involves ascending aorta replacement alone or ascending aorta plus hemiarch replacement, according to the operative strategy. The ascending aorta is replaced with or without replacement of the proximal aortic arch, while the distal arch and supra-aortic vessels are preserved.",[9],[27],"AAR\u002FAAR+HAR",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Ascending Aorta Replacement With Total Arch Replacement and Frozen Elephant Trunk","This procedure involves ascending aorta replacement with total arch replacement and frozen elephant trunk implantation. The entire aortic arch is replaced, and a frozen elephant trunk is implanted into the proximal descending aorta.",[15],[33],"AAR+TAR+FET",[35],{"name":36,"affiliation":37,"role":38},"kexiang Liu, Ph.D.","Department of Cardiovascular Surgery, The Second Hospital of Jilin University","PRINCIPAL_INVESTIGATOR",[40],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},"kexiang liu, MD，Ph.D.","CONTACT","17390920328",null,"kxliu64@hotmail.com",{"type":38,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":44,"oldOrganization":44},"Kexiang Liu, MD","Department of Cardiovascular Surgery, Second Hospital of Jilin University","100613904","aaraarhar-vs-aartarfet-for-type-a-aortic-intramural-hematoma-100613904",false,"NCT07272655","AAR\u002FAAR+HAR vs AAR+TAR+FET for Type A Aortic Intramural Hematoma","A Prospective, Randomized, Non-Inferiority Trial of AAR\u002FAAR+HAR Versus AAR+TAR+FET in Type A Aortic Intramural Hematoma","Inclusion Criteria:\n\n1. Age ≥ 18 years and ≤ 80 years.\n2. Diagnosis of type A aortic intramural hematoma (TAIMH).\n3. Ability to understand the study procedure and provide written informed consent.\n\nExclusion Criteria:\n\n1. Preoperative CTA shows an open or partially thrombosed (mixed) false lumen in the ascending aorta or arch.\n2. Primary tear located on the greater curvature of the aortic arch, necessitating total arch replacement.\n3. Planned concomitant major cardiac surgery (e.g., CABG, valve replacement, atrial fibrillation ablation).\n4. Previous history of aortic arch or distal aortic surgery.\n5. Severe peripheral vascular disease or cerebrovascular anatomy abnormality.\n6. Active systemic infection, malignancy, severe hepatic or renal dysfunction, or other major comorbidities with life expectancy \\\u003C 1 year or deemed unfit for complex cardiovascular surgery.\n7. Pregnancy or lactation.\n8. Severe psychiatric or cognitive disorders affecting compliance or follow-up.","ALL","18 Years","80 Years",{"count":60,"type":61},400,"ESTIMATED","INTERVENTIONAL",[64],"NA","This is a prospective, randomized, non-inferiority clinical trial designed to compare the efficacy and safety of two surgical strategies for acute type A aortic intramural hematoma (TAIMH): (1) ascending aorta replacement or ascending aorta plus hemiarch replacement (AAR\u002FAAR+HAR), and (2) ascending aorta replacement with total arch replacement and frozen elephant trunk implantation (AAR+TAR+FET). Patients will be enrolled based on CTA confirmation of a completely thrombosed false lumen in the ascending aorta and aortic arch. Eligible participants will be randomized in a 1:1 ratio to either group. The primary endpoint is the rate of reintervention on the aortic arch or descending aorta from 6 to 12 months after surgery. Secondary endpoints include circulatory arrest time, aortic cross-clamp time, major adverse cardiovascular events, other perioperative complications, and total hospitalization cost. A total of 400 participants will be enrolled.",[67],"Aortic Intramural Hematoma",[69,70,71,72],"Aortic Intramural Hematoma, Type A","Hemiarch Replacement","Total Arch Replacement","Non-Inferiority Trial","NOT_YET_RECRUITING","2026-05-04",{"date":76,"type":77},"2026-05-08","ACTUAL",{"date":79,"type":61},"2026-06-01",{"date":81,"type":61},"2027-10-30",{"name":5,"class":6}]