[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100549142":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":41,"centralContacts":45,"locations":50,"responsibleParty":64,"collaborators":29,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":29,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":29,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":52,"whyStopped":29,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Emory University","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Gait with functional electrical stimulation","EXPERIMENTAL","Participants will participate in 2 to 5 sessions over 2-8 weeks. Each session will comprise gait or stepping practice on a treadmill with functional electrical stimulation, and non-invasive measurement of neural circuit excitability.\n\nParticipants will complete multiple 30-second to 4-minute bouts of walking on the treadmill or overground at speeds ranging from self-selected to fast speeds (faster than comfortable self-selected speed), with rest breaks between bouts. For gait training, participants may complete up to six 6-minute bouts of walking with rest breaks between bouts (30-36 minutes walking).",[13,14],"Other: Gait Training","Device: Functional electrical stimulation (FES)",{"label":16,"type":10,"description":17,"interventionNames":18},"Gait without functional electrical stimulation","Participants will participate in 2 to 5 sessions over 2-8 weeks. Each session will comprise gait or stepping practice on a treadmill without functional electrical stimulation, and non-invasive measurement of neural circuit excitability.\n\nParticipants will complete multiple 30-second to 4-minute bouts of walking on the treadmill or overground at speeds ranging from self-selected to fast speeds (faster than comfortable self-selected speed), with rest breaks between bouts. For gait training, participants may complete up to six 6-minute bouts of walking with rest breaks between bouts (30-36 minutes walking).",[13],{"label":20,"type":10,"description":21,"interventionNames":22},"Paired stimulation of the cortex and peripheral nervous system","Participants will participate in a single session of peripheral electrical stimulation paired with cortical stimulation pulses (i.e. paired associative stimulation(PAS)) on somatosensory, spinal-reflex, and corticospinal neurophysiology.",[23],"Device: Peripheral electrical stimulation paired with cortical magnetic stimulation pulses",[25,30,37],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"Gait Training","Gait training: One or multiple short bouts of stepping practice on a treadmill at self-selected or fast speeds will be delivered without FES.",[9,16],null,{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"DEVICE","Functional electrical stimulation (FES)","Electrical stimulation involving the parameters and settings proposed here is commonly used in clinical practice and research for pain relief and other applications also referred to as neuromuscular or transcutaneous electrical nerve stimulation. The FES will be delivered using the UDel Stimulator, a custom-designed FES system from the University of Delaware FES lab.\n\nResearchers will use a customized, real-time system to control the stimulator and deliver stimulation during appropriate phases of the gait cycle. Stimulation will be delivered to the ankle dorsiflexors when the subject's foot is in the air (swing phase). Stimulation will be delivered to the ankle plantarflexors during the terminal stance phase of gait. 30-Hz variable frequency stimulation trains will be delivered during gait.",[9],[36],"FES",{"type":31,"name":38,"description":39,"armGroupLabels":40,"otherNames":29},"Peripheral electrical stimulation paired with cortical magnetic stimulation pulses","The paired associative stimulation (PAS) will be conducted in a static posture (seated or standing), to evaluate effects on somatosensory, spinal-reflex, and\u002For corticospinal neurophysiology delivered with different stimulation parameters. One or multiple short bouts of stepping practice on a treadmill at self-selected or fast speeds may be completed before and\u002For after PAS to evaluate gait performance",[20],[42],{"name":43,"affiliation":5,"role":44},"Trisha Kesar, PT, PhD","PRINCIPAL_INVESTIGATOR",[46],{"name":43,"role":47,"phone":48,"phoneExt":29,"email":49},"CONTACT","404-712-5803","tkesar@emory.edu",[51],{"facility":5,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":29},"RECRUITING","Atlanta","Georgia","30329","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-84.38798,33.749,{"lat":62,"lon":61},{"type":44,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"Trisha Kesar","Associate Professor","100549142","ab-gait-estim-neurophysiology-100549142",false,"NCT06430164","AB Gait Estim Neurophysiology","Effects of Gait Training Strategies and Noninvasive Stimulation on Neurophysiology and Walking Performance in Able-Bodied Adults- A Preliminary Study","Inclusion Criteria:\n\n* 18-65 years\n* Able-bodied (healthy without any physical disability, neurological, orthopedic, or other medical disorder affecting walking or study protocol participation)\n* Ability to walk \\>10m overground and for 1 minute on a treadmill\n* Ability to follow 3-stage commands and provide informed consent.\n\nExclusion Criteria:\n\n* Self-reported history or evidence of orthopedic or physical disability\n* History or evidence of neurological pathology\n* Pregnancy (female)\n* Uncontrolled hypertension\n* Cardiac pacemaker or other implanted electronic system\n* Presence of skin conditions preventing electrical stimulation setup\n* Impaired sensation in the left upper limb.\n* Bruises or cuts at the stimulation electrode placement site\n* Concurrent enrollment in rehabilitation or another investigational study.\n* History or evidence of orthopedic or physical disability interfering with study procedures\n* History or evidence of neurological pathology or disorder\n* Severe uncontrolled medical problems (e.g., hypertension, cardiovascular disease, rheumatoid arthritis, active cancer or renal disease, epilepsy) that may interfere with study procedures\n* Contraindications to TMS such as metal implants, medications that can increase cortical excitability, unexplained dizziness in the past 6 months",true,"ALL","18 Years","65 Years",{"count":79,"type":80},50,"ESTIMATED","INTERVENTIONAL",[83],"NA","This study is being done to answer the question: What are the effects of electrical stimulation and stepping practice on connections between the brain and muscles? The long-term goal of this project is to develop novel, effective, and personalized rehabilitation protocols founded on an understanding of neurobiological mechanisms that combine electrical stimulation with gait training to improve gait performance in older adults and stroke survivors.\n\nThe rationale of this project is to explore and generate preliminary data regarding how electrical stimulation-based strategies modulate cortical and spinal circuits in able-bodied individuals.\n\nThe researchers will evaluate the effects of short treadmill walking bouts or single gait training sessions with and without electrical stimulation on somatosensory, spinal-reflex, corticospinal circuit neurophysiology, and\u002For gait performance.\n\nThe study will provide important preliminary and normative data that can explain how brain circuits change with stimulation or stepping practice and inform future rehabilitation studies on patients. The study population is able-bodied individuals.",[86],"Gait",[88,89,32],"Corticospinal excitability","Non-invasive stimulation","2025-07-24",{"date":92,"type":93},"2025-07-28","ACTUAL",{"date":95,"type":93},"2024-02-12",{"date":97,"type":80},"2026-12",{"name":5,"class":6},1]