[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586597":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":44,"responsibleParty":59,"collaborators":25,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":25,"eligibilityCriteria":68,"healthyVolunteers":65,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":25,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":86,"whyStopped":25,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Tel-Aviv Sourasky Medical Center","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Abdominally targeted exercises","EXPERIMENTAL","The interventional exercise regimen will include specific abdominally targeted exercises postulated to increase blood flow to the intestine and decrease inflammation. Patients will be asked to perform the exercises 6 days every week. Patients will be asked to complete 3 different videos repeatedly, one video per day, as many days a week as possible.",[13],"Other: Abdominally targeted exercises",{"label":15,"type":16,"description":17,"interventionNames":18},"Generally recommended exercises","PLACEBO_COMPARATOR","The control arm will practice generally recommended exercises, without particular attention to the abdomen. Patients will be asked to perform the exercises 6 days every week. Patients will be asked to complete 3 different videos repeatedly, one video per day, as many days a week as possible.",[19],"Other: General exercises",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"OTHER","The interventional exercise regimen will include specific abdominally targeted exercises postulated to increase blood flow to the intestine and decrease inflammation.",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"General exercises","Generally recommended exercises, without particular attention to the abdomen",[15],[31],{"name":32,"affiliation":33,"role":34},"Nitsan Maharshak, Professor","Tel Aviv Medical Center","PRINCIPAL_INVESTIGATOR",[36,40],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","+972527360384","nitsanm@tlvmc.gov.il",{"name":41,"role":37,"phone":42,"phoneExt":25,"email":43},"Rony Izhar, PhD","+972504991116","ronyi@tlvmc.gov.il",[45],{"facility":46,"status":25,"city":47,"state":48,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Department of Gastroenterology and Liver Diseases, Tel Aviv Medical Center","Tel Aviv","Israel","IL",{"type":51,"coordinates":52},"Point",[53,54],34.78057,32.08088,{"lat":54,"lon":53},[57,58],{"name":41,"role":37,"phone":42,"phoneExt":25,"email":43},{"name":32,"role":34,"phone":25,"phoneExt":25,"email":25},{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Shmuel Kivity, MD","Professor","100586597","abdominally-targeted-management-exercises-for-crohns-disease-patients-tame-cd-100586597",false,"NCT06917443","Abdominally Targeted Management Exercises for Crohn's Disease Patients (TAME-CD)","Inclusion Criteria:\n\n* Patients with no treatment or on constant medicinal therapy, expected to remain constant: mesalamine for at least 6 weeks, steroids at least 2 weeks (≤20mg prednisone or budesonide ≤6mg), immunomodulatory at least 12 weeks or biologics\u002F small molecules for at least 12 weeks therapy. Patients who initiate the study on steroids will remain on a constant dose throughout the study.\n* If patients stopped therapy prior to the study then they should be at least 2 weeks from stopping steroids or 5ASA, or 4 weeks from stopping small molecules, 8 weeks from stopping biologics, or 12 weeks from stopping thiopurines.\n* CD patients will be included if their symptoms score \\>4 and ≤15 on the HBI score\n* Fecal calprotectin\\>150ug\u002Fgr or evidence of an active disease per IUS defined as increased blood flow (modified Limberg score\\>0) or thickness of bowel wall\\>3mm\n\nExclusion Criteria:\n\n* Inability to commit for performing at least 10-15 minutes of exercise, 6 times a week.\n* Lack of availability or capability to use a computer\u002F internet.\n* Any proven current infection such as, fever, active abscess, Clostridioides difficile infection, positive stool culture, or parasite in patients with chronic diarrhea.\n* Inability to sign informed consent and\u002F or complete the study protocol.\n* Incompetent individuals who are unable to provide informed consent.\n* Planed pregnancy or pregnancy- up to 3 months post labor.\n* Subjects with chronic conditions such as active arthritis, cancer (within the previous 5 years, not including BCC, SCC), organ transplant subjects, advanced kidney or liver disease, or systemic inflammatory conditions other than IBD.\n* Patients who underwent surgery in the previous 3 months, had more than 1 surgery of intestinal resection, patients with ileostomy, pouch or patients with short bowel (small intestine\\\u003C1.5 meter).\n* Patients with a significant abdominal wall hernia, unless received a written confirmation from a treating surgeon.\n* Active peri-anal disease (fistula, abscess, fissure), stricturing or penetrating disease\n* Active extra-intestinal manifestations (not excluded are- oral aphthae and peripheral arthralgia without arthritis)\n* Patients on total parenteral nutrition (TPN) or on exclusive enteral nutrition (EEN).\n* Probiotics or antibiotics in the 15 days prior to enrollment or during the study period.","ALL","18 Years","60 Years",{"count":73,"type":74},42,"ESTIMATED","INTERVENTIONAL",[77],"NA","The goal of this clinical trial is to learn if abdominally targeted exercises can assist to manage disease activity in Crohn disease (CD) patients.\n\nThe main questions it aims to answer are:\n\nDoes abdominally targeted exercises can improve the quality of life of CD patients.\n\nDoes abdominally targeted exercises positively influence clinical and biological responses in CD patients.\n\nResearchers will compare performing sets of special physical exercises designed for CD patients, compared to a control set of exercises (\"generic\" physical activity) to see if exercises designed for CD can result in an improved quality of life, in CD patients suffering from mild to moderate disease activity.\n\nParticipants will:\n\n* Perform physical exercises designed for CD or control set of exercises every day for 8 weeks.\n* Visit the clinic once every 4 weeks for doctor visit, blood and stool test and filling out questionnaires.",[80,81],"Crohn Disease (CD)","IBD (Inflammatory Bowel Disease)",[83,84,85],"physical exercise","Crohn's disease","randomized trial","NOT_YET_RECRUITING","2025-03-31",{"date":89,"type":90},"2025-04-08","ACTUAL",{"date":92,"type":74},"2025-04",{"date":94,"type":74},"2029-08",{"name":61,"class":6},1]