[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100578160":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":26,"locations":36,"responsibleParty":53,"collaborators":25,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":25,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":25,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":39,"whyStopped":25,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Christiana Care Health Services","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"phase 1","SHAM_COMPARATOR","During phase I (3 weeks), half of the subjects will receive rTMS, while the other half will receive sham stimulation.",[13],"Device: transcranial magnetic stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"phase 2","ACTIVE_COMPARATOR","During phase II (3 weeks) all subjects will receive active stimulation.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","transcranial magnetic stimulation","The investigators will deliver a type of high frequency rTMS known as intermittent theta burst stimulation (iTBS), 2400 stimulations per session, equally divided between the bilateral IPL and IFG.",[9,15],null,[27,32],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},"Mitra Assadi, MD","CONTACT","3026233017","mitra.assadi@christianacare.org",{"name":33,"role":29,"phone":34,"phoneExt":25,"email":35},"Ryan Ally, MD","302-320-2100","ryan.ally@christianacare.org",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Christiana Care","RECRUITING","Newark","Delaware","19718","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-75.74966,39.68372,{"lat":49,"lon":48},[52],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Mitra Assadi","Director, Professor of Neurology","100578160","abnormal-connectivity-involving-the-social-reciprocity-network-in-autism-and-the-impact-of-neurostimulation-in-mitigating-the-abnormalities-100578160",false,"NCT06807684","Abnormal Connectivity Involving the Social Reciprocity Network in Autism and the Impact of Neurostimulation in Mitigating the Abnormalities","Discerning the Abnormal Functional Connectivity Involving the Social Reciprocity Network in Autism Spectrum Disorder and the Impact of Transcranial Magnetic Stimulation in Mitigating the Abnormalities","Inclusion criteria\n\n1\\. Fulfilling the DSM-V criteria for ASD and confirmed by CARS2, HF Exclusion criteria\n\n1. Patients with ASD exhibiting significant anxiety or contact avoidance, precluding them from cooperating with the procedure\n2. Patients with a known diagnosis of seizures\n3. Presence of any metallic implants or devices in the head or neck area\n4. Pregnant women","ALL","13 Years","18 Years",{"count":68,"type":69},12,"ESTIMATED","INTERVENTIONAL",[72],"NA","There is no consensus regarding the neurological substrate underpinning ASD. The investigators describe the novel concept of \"social reciprocity network\" and hypothesize that aberrant connectivity\u002Foscillatory patterns affecting this network contribute to the core deficits in ASD.\n\nThe overarching goal of this trial is to explore abnormalities involving the neuronal connectivity and oscillatory patterns within the social reciprocity network and to elucidate the role of modulating this network via rTMS in improving the above measures and social cognition in ASD. Quantitative electroencephalography (QEEG) coherence and spectral power analysis are reliable measures of neuronal connectivity and dynamics. The investigators aim to study the QEEG coherence\u002Fspectral power analysis to explore the neuronal dynamics affecting the social reciprocity network in ASD.",[75],"Autism Spectrum Disorder",[77,22,78],"Autism spectrum","neuronal connectivity","2025-02-20",{"date":81,"type":82},"2025-02-21","ACTUAL",{"date":84,"type":82},"2024-08-15",{"date":86,"type":69},"2025-12-31",{"name":5,"class":6},1]