[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570230":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":25,"responsibleParty":103,"collaborators":10,"id":106,"slug":107,"hasResults":108,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":10,"eligibilityCriteria":112,"healthyVolunteers":108,"sex":113,"minAge":10,"maxAge":10,"enrollmentInfo":114,"targetDuration":10,"studyType":117,"phases":10,"briefSummary":118,"conditions":119,"keywords":10,"overallStatus":123,"whyStopped":10,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":133},{"fullName":5,"class":6},"Ruijin Hospital","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Case Group",null,"patients who underwent allogeneic hematopoietic stem cell transplantation from March 2019 to March 2024; donor fasting blood glucose and\u002For HbA1c data available; fasting blood glucose ≥6.1 mmol\u002FL or HbA1c ≥5.7%",{"label":13,"type":10,"description":14,"interventionNames":10},"Control Group","patients who underwent allogeneic hematopoietic stem cell transplantation from March 2019 to March 2024; donor fasting blood glucose and\u002For HbA1c data available; fasting blood glucose \\\u003C6.1 mmol\u002FL; HbA1c \\\u003C5.7% (if available)",[16],{"name":17,"affiliation":5,"role":18},"Jingtao Huang","PRINCIPAL_INVESTIGATOR",[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Xiaoxia Hu","CONTACT","(86) 13795437259","hu_xiaoxia@126.com",[26,42,55,68,78,91],{"facility":27,"status":10,"city":28,"state":29,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"The First Affiliated Hospital of Zhengzhou University","Zhengzhou","Henan","China","CN",{"type":33,"coordinates":34},"Point",[35,36],113.64861,34.75778,{"lat":36,"lon":35},[39],{"name":40,"role":22,"phone":10,"phoneExt":10,"email":41},"Weijie Cao","caoweijie2003@126.com",{"facility":43,"status":10,"city":44,"state":45,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":46,"geoPoint":50,"contacts":51},"Tongji Hospital of Huazhong University of Science and Technology, Wuhan","Wuhan","Hubei",{"type":33,"coordinates":47},[48,49],114.26667,30.58333,{"lat":49,"lon":48},[52],{"name":53,"role":22,"phone":10,"phoneExt":10,"email":54},"Yang Cao","yangcao@tjh.tjmu.edu.cn",{"facility":56,"status":10,"city":57,"state":58,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"Li Quan Hospital","Shanghai","Shanghai Municipality",{"type":33,"coordinates":60},[61,62],121.45806,31.22222,{"lat":62,"lon":61},[65],{"name":66,"role":22,"phone":10,"phoneExt":10,"email":67},"Chun Wang","wangchun2@medmail.com.cn",{"facility":69,"status":10,"city":57,"state":58,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":70,"geoPoint":72,"contacts":73},"Ruijin Hospital of Shanghai Jiaotong University",{"type":33,"coordinates":71},[61,62],{"lat":62,"lon":61},[74],{"name":75,"role":22,"phone":76,"phoneExt":10,"email":77},"Xiaoxia Hu, Doctor","(86) 021-64370045","hxx12276@rjh.com.cn",{"facility":79,"status":10,"city":80,"state":81,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"The First Hospital of Zhejiang University School of Medicine","Hangzhou","Zhejiang",{"type":33,"coordinates":83},[84,85],120.16142,30.29365,{"lat":85,"lon":84},[88],{"name":89,"role":22,"phone":10,"phoneExt":10,"email":90},"Yanmin Zhao","yanminzhao@zju.edu.cn",{"facility":92,"status":10,"city":93,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":94,"geoPoint":98,"contacts":99},"Hospital of Hematology of the Chinese Academy of Medical Sciences","Tianjin",{"type":33,"coordinates":95},[96,97],117.17667,39.14222,{"lat":97,"lon":96},[100],{"name":101,"role":22,"phone":10,"phoneExt":10,"email":102},"Yawei Zheng","zhengyawei@ihcams.ac.cn",{"type":18,"investigatorFullName":104,"investigatorTitle":105,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Hu Xiaoxia","Director of the Center for Translational Medicine","100570230","abnormal-glucose-tolerance-in-allogeneic-hematopoietic-stem-cell-transplantation-100570230",false,"NCT06704542","Abnormal Glucose Tolerance in Allogeneic Hematopoietic Stem Cell Transplantation","A Study of the Impact of Abnormal Glucose Tolerance in Allogeneic Hematopoietic Stem Cell Transplantation Donors on Recipients' Post-Transplant Survival Outcomes: A Multicenter Retrospective Cohort Study Based on HIS Data","Inclusion Criteria:\n\n* Patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT) between March 2019 and March 2024;\n* Donor had fasting blood glucose and\u002For HbA1c records\n* Eastern Cooperative Oncology Group (ECOG) physical fitness score of 0-2\n* Survived at least 12 weeks after HSCT\n* Voluntarily signed the Informed Consent Form\n* Had appropriate organ function;\n* Laboratory results within 7 days prior to HSCT met the following criteria:\n\n  1. Aspartate aminotransferase (AST) ≤ 3-fold (upper limit of norma, ULN);\n  2. Alanine aminotransferase (ALT) ≤ 3x ULN;\n  3. Total serum bilirubin ≤ 1.5 times the upper limit of normal ULN unless the patient has documented Gilbert syndrome; patients with Gilbert-Meulengracht syndrome with bilirubin ≤ 3.0 times the upper limit of normal and direct bilirubin ≤ 1.5 times the upper limit of normal may be included;\n  4. Serum creatinine ≤ 1.5 times ULN or creatinine clearance ≥ 60 mL\u002Fmin;\n  5. Coagulation function: International Normalized Ratio (INR) ≤1.5×ULN, Activated Partial Thromboplastin Time (APTT) ≤1.5×ULN;\n\nExclusion Criteria:\n\n* Active autoimmune diseases such as SLE, rheumatoid arthritis, etc.\n* Active cardiovascular disease such as uncontrolled arrhythmias, uncontrolled hypertension, congestive heart failure, any Grade 3 or 4 heart disease as determined by the New York Heart Association (NYHA) Functional Class, or a history of myocardial infarction in the 6 months prior to screening;\n* Other serious medical conditions that may limit the patient's participation in this trial (e.g., progressive infection, uncontrolled diabetes);\n* HIV infection, or chronic infection with hepatitis B virus (HBsAg-positive) or hepatitis C virus (anti-HCV-positive) that cannot be controlled by medications;\n* Patients with other uncured tumors\n* Patients with neurological or psychiatric disorders\n* Patients who were unable to understand or comply with the research protocol or are unable to sign the Informed Consent Form","ALL",{"count":115,"type":116},1000,"ESTIMATED","OBSERVATIONAL","To investigate the impact of abnormal glucose tolerance in hematopoietic stem cell transplantation donors on patients' post-transplant survival outcomes.",[120,121,122],"ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION","Diabetes Mellitus","Impaired Fasting Glucose","NOT_YET_RECRUITING","2024-11-24",{"date":126,"type":127},"2024-11-26","ACTUAL",{"date":129,"type":116},"2024-11",{"date":131,"type":116},"2025-04",{"name":5,"class":6},6]