[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623310":3},{"organization":4,"armGroups":7,"interventions":55,"overallOfficials":93,"centralContacts":97,"locations":103,"responsibleParty":119,"collaborators":60,"id":123,"slug":124,"hasResults":125,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":129,"eligibilityCriteria":130,"healthyVolunteers":131,"sex":132,"minAge":133,"maxAge":134,"enrollmentInfo":135,"targetDuration":60,"studyType":138,"phases":139,"briefSummary":141,"conditions":142,"keywords":144,"overallStatus":106,"whyStopped":60,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":161},{"fullName":5,"class":6},"ETH Zurich","OTHER",[8,14,19,25,30,35,40,45,50],{"label":9,"type":10,"description":11,"interventionNames":12},"Ferrous sulfate + inhibitory meal","ACTIVE_COMPARATOR","4 mg of iron (58Fe) as ferrous sulfate + inhibitory meal",[13],"Other: FeSO4 + meal-matrix",{"label":15,"type":10,"description":16,"interventionNames":17},"Ferrous sulfate + native LF + inhibitory meal","4 mg iron (58Fe) as ferrous sulfate + native LF + inhibitory meal",[18],"Other: FeSO4 + native LF + meal-matrix",{"label":20,"type":21,"description":22,"interventionNames":23},"Ferrous sulfate + encapsulated LF (sodium caseinate) + inhibitory meal","EXPERIMENTAL","4 mg iron (57Fe) as ferrous sulfate + sodium caseinate-LF + inhibitory meal",[24],"Other: FeSO4 + NaCas-LF + meal-matrix",{"label":26,"type":21,"description":27,"interventionNames":28},"Encapsulated LF-Fe (Sodium caseinate) + inhibitory meal","4 mg of iron (54Fe) encapsulated with LF in sodium caseinate + inhibitory meal",[29],"Other: NaCas-LF-Fe + meal-matrix",{"label":31,"type":21,"description":32,"interventionNames":33},"Ferrous sulfate + encapsulated LF (low methoxy pectin) + inhibitory meal","4 mg of iron (54Fe) as ferrous sulfate + low methoxy pectin-LF + inhibitory meal",[34],"Other: FeSO4 + LMP-LF + meal-matrix",{"label":36,"type":21,"description":37,"interventionNames":38},"Encapsulated LF-Fe (low methoxy pectin) + inhibitory meal","4 mg of iron (57Fe) encapsulated with LF in low methoxy pectin + inhibitory meal",[39],"Other: LMP-LF-Fe + meal-matrix",{"label":41,"type":21,"description":42,"interventionNames":43},"Encapsulated LF-Fe (sodium caseinate) + water","100 mg of iron encapsulated with LF in sodium caseinate + water",[44],"Other: NaCas-LF-Fe + water",{"label":46,"type":21,"description":47,"interventionNames":48},"Encapsulated LF-Fe (low methoxy pectin) + water","100 mg of iron encapsulated with LF in low methoxy pectin + water",[49],"Other: LMP-LF-Fe + water",{"label":51,"type":10,"description":52,"interventionNames":53},"Ferrous sulfate + water","100 mg of iron as ferrous sulfate + water",[54],"Other: FeSO4 + water",[56,61,65,69,73,77,81,85,89],{"type":6,"name":57,"description":58,"armGroupLabels":59,"otherNames":60},"FeSO4 + meal-matrix","Maize porridge with labelled ferrous sulfate (58Fe)",[9],null,{"type":6,"name":62,"description":63,"armGroupLabels":64,"otherNames":60},"FeSO4 + native LF + meal-matrix","Maize porridge with labelled ferrous sulfate (58Fe) and lactoferrin",[15],{"type":6,"name":66,"description":67,"armGroupLabels":68,"otherNames":60},"FeSO4 + NaCas-LF + meal-matrix","Maize porridge with labelled ferrous sulfate (57Fe) and in sodium caseinate encapsulated lactoferrin",[20],{"type":6,"name":70,"description":71,"armGroupLabels":72,"otherNames":60},"NaCas-LF-Fe + meal-matrix","Maize porridge with sodium caseinate-lactoferrin-Fe (intrinsically labeled with iron isotope 54)",[26],{"type":6,"name":74,"description":75,"armGroupLabels":76,"otherNames":60},"FeSO4 + LMP-LF + meal-matrix","Maize porridge with labelled ferrous sulfate (54Fe) and low methoxy pectin lactoferrin",[31],{"type":6,"name":78,"description":79,"armGroupLabels":80,"otherNames":60},"LMP-LF-Fe + meal-matrix","Maize porridge with low methoxy pectin-lactoferrin-Fe (intrinsically labelled with iron isotope 57)",[36],{"type":6,"name":82,"description":83,"armGroupLabels":84,"otherNames":60},"NaCas-LF-Fe + water","Water with sodium caseinate-lactoferrin-Fe (intrinsically labelled with iron isotope 54Fe)",[41],{"type":6,"name":86,"description":87,"armGroupLabels":88,"otherNames":60},"LMP-LF-Fe + water","Water with low methoxy pectin-lactoferrin-Fe (intrinsically labelled with iron isotope 57Fe)",[46],{"type":6,"name":90,"description":91,"armGroupLabels":92,"otherNames":60},"FeSO4 + water","Water with ferrous sulfate (labelled with iron isotope 58Fe)",[51],[94],{"name":95,"affiliation":5,"role":96},"Nicole Ursula Stoffel, Prof.","PRINCIPAL_INVESTIGATOR",[98],{"name":99,"role":100,"phone":101,"phoneExt":60,"email":102},"Salome Häcki, MSc","CONTACT","+41 44 632 75 78","lobsterstudy@pharma.ethz.ch",[104],{"facility":105,"status":106,"city":107,"state":60,"zip":108,"country":109,"countryCode":110,"cosmosGeoPoint":111,"geoPoint":116,"contacts":117},"ETH Zurich, Laboratory of Clinical Biopharmacy","RECRUITING","Zurich","8092","Switzerland","CH",{"type":112,"coordinates":113},"Point",[114,115],8.55,47.36667,{"lat":115,"lon":114},[118],{"name":99,"role":100,"phone":101,"phoneExt":60,"email":102},{"type":120,"investigatorFullName":121,"investigatorTitle":122,"investigatorAffiliation":5,"oldNameTitle":60,"oldOrganization":60},"SPONSOR_INVESTIGATOR","Nicole Stoffel","Prof. Dr.","100623310","absorption-of-iron-from-stabilized-lactoferrin-a-study-in-women-with-iron-deficiency-100623310",false,"NCT07394972","Absorption of Iron From Stabilized Lactoferrin: A Study in Women With Iron Deficiency","Iron Absorption From Stabilized Lactoferrin: An Experimental Study in Iron Deficient Women (LOBSTER)","LOBSTER","Inclusion Criteria:\n\n* Serum ferritin \\\u003C 45 µg\u002FL (iron depleted)\n* Body weight \\\u003C 70 kg\n* Body mass index 18,5 - 24,9 kg\u002Fm2 (normal weight)\n* Hemoglobin (Hb) \\> 120 g\u002FL (nonanemic)\n* C-reactive protein (CRP) \\\u003C 5 mg\u002FL (no inflammation)\n\nExclusion Criteria:\n\n* Pregnant or lactating\n* Strictly vegan\n* Cigarette smoking (\\> 1 cigarette \u002F week)\n* Gastrointestinal or metabolic disorders affecting iron absorption or metabolism\n* Use of medication known to affect iron metabolism (oral contraceptives are allowed)\n* Intake of vitamin and mineral supplements in the 2 weeks before study start and during the study\n* Blood transfusion, blood donation, or significant blood loss during the previous 4 months\n* once enrolled, inability to follow study procedures or major illness\n* Participation in another study with investigational drug within the 30 days preceding and during the present study",true,"FEMALE","18 Years","45 Years",{"count":136,"type":137},45,"ESTIMATED","INTERVENTIONAL",[140],"NA","Lactoferrin (LF) is a natural iron-binding protein found in milk. It exists either in an iron-free state (apo-LF) or bound to iron (holo-LF). Whether LF binds iron to facilitate its absorption and\u002For to sequester iron from potential enteropathogens remains uncertain. However, while LF is a promising tool for treating iron deficiency, it is sensitive to heat during food processing and to the acidic environment of the human stomach. This degradation often causes LF to lose its functional properties before it can promote iron absorption effectively.\n\nThis study aims to evaluate whether encapsulating apo-LF (either alone or in combination with iron) can protect LF from digestion and enhance iron absorption. Using a randomized, crossover design, different encapsulation methods will be compared to determine which results in the highest iron absorption in women with iron deficiency.\n\nAll test compounds will be labeled with stable iron isotopes. Participants will consume the labeled compounds with a test meal or water in a randomized order, allowing for within subject comparisons. Fractional iron absorption will be measured 17 days after administration via the incorporation of labeled iron into red blood cells.",[143],"Iron Deficiency (Without Anemia)",[145,146,147,148,149,150,151],"Lactoferrin","Iron Deficiency","Iron Absorption","Iron Fortification","Stable Iron Isotopes","Dietary Supplements","Iron Bioavailability","2026-02-11",{"date":154,"type":155},"2026-02-12","ACTUAL",{"date":157,"type":137},"2026-02-17",{"date":159,"type":137},"2026-05",{"name":121,"class":6},1]