[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599253":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":24,"locations":18,"responsibleParty":30,"collaborators":18,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":18,"eligibilityCriteria":40,"healthyVolunteers":41,"sex":42,"minAge":43,"maxAge":18,"enrollmentInfo":44,"targetDuration":18,"studyType":47,"phases":48,"briefSummary":50,"conditions":51,"keywords":18,"overallStatus":53,"whyStopped":18,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":18},{"fullName":5,"class":6},"Universita degli Studi di Genova","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Treated abutments","EXPERIMENTAL","abutment allocated to the test group were placed in an Argon plasma reactor (Plasmapp, South Korea) for decontamination and activation",[13],"Device: the test group were placed in an Argon plasma reactor",{"label":15,"type":16,"description":17,"interventionNames":18},"Non treated abutment","NO_INTERVENTION","Abutment without any surface treatment",null,[20],{"type":21,"name":22,"description":22,"armGroupLabels":23,"otherNames":18},"DEVICE","the test group were placed in an Argon plasma reactor",[9],[25],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},"Luigi Canullo","CONTACT","+393476201976‬","luigicanullo@yahoo.com",{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"SPONSOR_INVESTIGATOR","Paolo Pesce","Professor","100599253","abutment-hydrophilicity-on-soft-tissue-morphogenesis-100599253",false,"NCT07082088","Abutment Hydrophilicity on Soft Tissue Morphogenesis","Effect of Abutment Hydrophilicity on Soft Tissue Morphogenesis: Histological CCT","Inclusion Criteria:\n\n* presence of at least 4 mm of keratinized mucosa around the implants\n* patients aged 18 years or older\n* medically healthy patients (ASA I), or patients with mild systemic disease (ASA II)\n* partially edentulous state\n* healthy periodontal condition (also including periodontal health on reduced periodontium) according to the referent case definition\n\nExclusion Criteria:\n\n* ASA physical status 3\n* severe smokers (\\> 10 cig\u002Fday)\n* patients undergoing bisphosphonate therapy\n* pregnant or lactating women\n* estrogen-related hormonal disorders or hormonal substitution therapy\n* untreated periodontitis (pocket depth 4mm with positive bleeding on probing)\n* multiple gingival recession\n* patients with a history of head and neck cancers and radiotherapy in this region.",true,"ALL","18 Years",{"count":45,"type":46},40,"ESTIMATED","INTERVENTIONAL",[49],"NA","The goal of this clinical trial is to evaluate the effect of abutment surface bioactivation via argon plasma treatment on peri-implant soft tissue healing and integration in adult patients undergoing implant therapy.\n\nThe main questions it aims to answer are:\n\nDoes argon plasma treatment of healing abutments improve the quality and organization of peri-implant connective tissue compared to untreated abutments?\n\nDoes the treatment influence histological parameters such as epithelial regeneration, vascularization, inflammatory infiltrate, and keratin layer thickness?\n\nResearchers will compare plasma-treated healing abutments to untreated machined-surface abutments to determine whether the bioactivated surface improves soft tissue morphogenesis.\n\nParticipants will:\n\nUndergo implant placement with immediate connection of either a treated or untreated healing abutment.\n\nHave plaque and bleeding indices recorded at 3 months.\n\nUndergo a soft tissue biopsy at 3 months for histological analysis (including evaluation of inflammation, connective tissue, epithelial morphology, vascularization, and keratinization).",[52],"Missing Tooth\u002FTeeth","NOT_YET_RECRUITING","2025-07-15",{"date":56,"type":57},"2025-07-24","ACTUAL",{"date":59,"type":46},"2025-07-31",{"date":61,"type":46},"2025-10-30",{"name":32,"class":6}]