[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604351":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":26,"locations":32,"responsibleParty":48,"collaborators":25,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":25,"enrollmentInfo":62,"targetDuration":25,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":35,"whyStopped":25,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"AiTBS group","EXPERIMENTAL","Eligible patients were receive 5 days of AiTBS on left M1 within 10 days. Clinical and neurophysiological assessments were performed at baseline and after the last sessions.",[13],"Device: Repetitive transcranial magnetic stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"10Hz rTMS","ACTIVE_COMPARATOR","Patients were assigned to receive 10 consecutive days of classic 10Hz rTMS intervention on left M1. Clinical and neurophysiological assessments were performed at baseline and after the last sessions.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Repetitive transcranial magnetic stimulation","Patients in the AiTBS group received 5 consecutive days of AiTBS treatment, with 6 sessions of iTBS interventions per day (1800 pulses per trial, with a 50-minute interval between trials). Patients in the 10Hz rTMS group received 10 consecutive days of 10Hz rTMS treatment within 10 days, with 1500 pulses per day, totaling 15 minutes.",[15,9],null,[27],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},"Ying Liu","CONTACT","86-15595512306","350373328@qq.com",[33],{"facility":34,"status":35,"city":36,"state":25,"zip":25,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"The Second Affiliated Hospital of Zhejiang University School of Medicine","RECRUITING","Hangzhou","China","CN",{"type":40,"coordinates":41},"Point",[42,43],120.16142,30.29365,{"lat":43,"lon":42},[46],{"name":28,"role":29,"phone":47,"phoneExt":25,"email":31},"15595512306",{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Min Yan","prof.","100604351","accelerated-intermittent-theta-burst-stimulation-aitbson-neuropathic-pain-100604351",false,"NCT07148388","Accelerated Intermittent Theta Burst Stimulation (AiTBS)on Neuropathic Pain","Effects and Mechanism of Accelerated Intermittent Theta Burst Stimulation on Neuropathic Pain","AiTBS","Inclusion Criteria:\n\n* IASP diagnosis of peripheral neuropathic pain;\n* At least three months after the onset of pain;\n* At least moderate pain intensity (≥ 3 assessed by VAS or NRS);\n* 18 years or older;\n* Stable medical treatment from 2 weeks before allocation to the end of the trial;\n* Willing to receive TMS treatment and capable of fulfilling clinical assessments.\n\nExclusion Criteria:\n\n* Contradictions to TMS treatment, such as metal implants or seizure;\n* Serious psychiatric disorder (Hamilton Depression Rating Scale score ≥ 35 or Hamilton Anxiety Rating Scale score ≥ 29);\n* Aphasia or cognitive disorders (Mini mental state examination ≤ 24);\n* Severe clinical disorders caused by tumor or other conditions;\n* Severe cardiopulmonary dysfunction or extreme weakness;\n* History of substance abuse (alcohol, drugs).","ALL","18 Years",{"count":63,"type":64},120,"ESTIMATED","INTERVENTIONAL",[67],"NA","The present study was designed to be the first to evaluate the efficacy of the AiTBS protocol to relieve neuropathic pain in a therapeutic setting, i.e. with repeated stimulation sessions. The investigator directly compared the analgesic efficacy of AiTBS versus conventional 10-Hz rTMS delivered to the left M1. In addition to pain experiences, The investigator examined the effects of intervention on corticospinal excitability that assessed by TMS-EEG. The working hypothesis was that AiTBS would result in larger analgesic and significant cortical excitability changes compared to 10-Hz rTMS.\n\nEligible patients were randomly assigned to receive either 5 days of AiTBS within 10 days (6 sessions per day) or 10 consecutive days of classic 10Hz rTMS intervention. Clinical and neurophysiological assessments were performed at baseline and after the last sessions.",[70],"Neuropathic Pain, Nociceptive Pain",[72],"AiTBS, rTMS, Neuropathic pain","2026-01-22",{"date":75,"type":76},"2026-01-26","ACTUAL",{"date":78,"type":76},"2025-09-12",{"date":80,"type":64},"2027-12-31",{"name":5,"class":6},1]