[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645324":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":26,"locations":37,"responsibleParty":55,"collaborators":20,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":20,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":20,"enrollmentInfo":66,"targetDuration":20,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":76,"overallStatus":87,"whyStopped":20,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":98},{"fullName":5,"class":6},"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Accelerated iTBS","EXPERIMENTAL","Participants will receive active accelerated intermittent theta burst stimulation (iTBS). Treatment will consist of six short stimulation sessions per day delivered over five consecutive days, for a total of 30 sessions.",[13],"Device: Accelerated intermittent theta burst stimulation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Accelerated intermittent theta burst stimulation","Accelerated intermittent theta burst stimulation, also called accelerated iTBS, is a non-invasive magnetic brain stimulation intervention. Stimulation is delivered to the left dorsolateral prefrontal cortex using a transcranial magnetic stimulation system. Participants receive six short sessions per day over five consecutive days.",[9],null,[22],{"name":23,"affiliation":24,"role":25},"Radhika Kelkar, MD","St. Joseph's Health Care London, Parkwood Institute, Finch Family Mental Health Care Building","PRINCIPAL_INVESTIGATOR",[27,32],{"name":23,"role":28,"phone":29,"phoneExt":30,"email":31},"CONTACT","519-685-8500","75805","radhika.kelkar@lhsc.on.ca",{"name":33,"role":28,"phone":34,"phoneExt":35,"email":36},"Mervin Blair, PhD, C.Psych","519-646-6100","48170","mervin.blair@sjhc.london.on.ca",[38],{"facility":39,"status":20,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"St. Joseph's Health Care London, Parkwood Institute Mental Health Care Building","London","Ontario","N6C 0A7","Canada","CA",{"type":46,"coordinates":47},"Point",[48,49],-81.23304,42.98339,{"lat":49,"lon":48},[52,53,54],{"name":23,"role":28,"phone":29,"phoneExt":30,"email":31},{"name":33,"role":28,"phone":34,"phoneExt":35,"email":36},{"name":23,"role":25,"phone":20,"phoneExt":20,"email":20},{"type":56,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100645324","accelerated-itbs-for-ptsd-and-depression-100645324",false,"NCT07682207","Accelerated iTBS for PTSD and Depression","Accelerated Intermittent Theta Burst Stimulation for Depression in Post-Traumatic Stress Disorder: A Single-Arm, Open-Label Feasibility Study","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Current post-traumatic stress disorder (PTSD) and current major depressive disorder (MDD), confirmed by a structured diagnostic interview (e.g., MINI 6.0 using the PTSD and MDD modules).\n* Minimum symptom severity at baseline: HAMD-17 score ≥14 (moderate depression) and\u002For PCL-5 score ≥33 (probable PTSD).\n* On a stable pharmacologic and\u002For psychotherapeutic regimen for at least 4 weeks prior to baseline, and willing to maintain stability during the treatment phase, unless medically necessary.\n* Capacity to provide informed consent and comply with study procedures and visits at St. Joseph's Health Care, London\u002FParkwood Institute.\n* Sufficient English proficiency to complete consent and study assessments.\n\nExclusion Criteria:\n\n* Neurologic or device-related risks, including seizure history, traumatic brain injury with loss of consciousness greater than 5 minutes, major neurologic illness, or metal\u002Felectronic implants contraindicated for transcranial magnetic stimulation.\n* Psychiatric or substance-related risks, including current psychotic disorder, acute mania, diagnosis of Bipolar I or Bipolar II disorder, recent substance use disorder, or imminent suicide risk.\n* Medical or medication-related risks, including unstable severe illness, high-risk medications, hearing impairment, unwillingness to use ear protection, or prior non-response to an adequate course of theta burst stimulation for the current depression\u002FPTSD episode.\n* Enrollment in another interventional trial.\n* Inability to comply with the study schedule.","ALL","18 Years",{"count":67,"type":68},16,"ESTIMATED","INTERVENTIONAL",[71],"NA","The goal of this pilot clinical trial is to learn if a faster brain stimulation schedule is practical, safe, tolerable, and acceptable. This study looks at accelerated intermittent theta burst stimulation, or accelerated iTBS. This is a non-invasive type of magnetic brain stimulation. This study is for adults with post-traumatic stress disorder (PTSD) and major depressive disorder (MDD).\n\nThe main questions this study aims to answer are:\n\n1. Can participants complete six short brain stimulation sessions per day for five days?\n2. Is this treatment schedule safe and tolerable for participants?\n3. What changes occur in depression symptoms, PTSD symptoms, anxiety, quality of life, and brain activity over time?\n\nParticipants will:\n\n1. Complete health screening and baseline assessments.\n2. Receive six short sessions of magnetic brain stimulation per day for five days.\n3. Have their brain activity measured using an EEG recording.\n4. Return for a post-treatment assessment at Week 2 and follow-up visits at Week 5 and Week 12.",[74,75],"Post Traumatic Stress Disorder PTSD","Major Depressive Disorder (MDD)",[77,78,79,80,17,81,82,83,84,85,86],"PTSD","MDD","Depression","Feasibility study","iTBS","Theta burst stimulation","Transcranial magnetic stimulation","TMS","Brain stimulation","EEG","NOT_YET_RECRUITING","2026-06-26",{"date":90,"type":91},"2026-07-02","ACTUAL",{"date":93,"type":68},"2026-07",{"date":95,"type":68},"2027-09",{"name":97,"class":6},"Lawson Research Institute of St. Joseph's",1]