[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622160":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":54,"collaborators":22,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":59,"sex":65,"minAge":66,"maxAge":22,"enrollmentInfo":67,"targetDuration":22,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":39,"whyStopped":22,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"University of Thessaly","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"One sachet of the probiotic daily","Twenty participants will receive one sachet of the probiotic daily.",[12],"Dietary Supplement: One sachet of the probiotic daily",{"label":14,"type":6,"description":15,"interventionNames":16},"Two sachets of the probiotic daily","Twenty participants will receive two sachets of the probiotic daily.",[17],"Dietary Supplement: Two sachets of the probiotic daily",[19,23],{"type":20,"name":9,"description":10,"armGroupLabels":21,"otherNames":22},"DIETARY_SUPPLEMENT",[9],null,{"type":20,"name":14,"description":15,"armGroupLabels":24,"otherNames":22},[14],[26],{"name":27,"affiliation":28,"role":29},"ODYSSEAS ANDROUTSOS","Lab of Clinical Nutrition and Dietetics, Department of Nutrition and Dietetics, School of Physical Education, Sports Science and Dietetics, University of Thessaly, 42100 Trikala, Greece","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":22,"email":35},"VAIOS SVOLOS, PhD","CONTACT","+30 6989953903","vaiossvolos@gmail.com",[37],{"facility":38,"status":39,"city":40,"state":22,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"School of Physical Education, Sport Science and Dietetics","RECRUITING","Trikala","42132","Greece","GR",{"type":45,"coordinates":46},"Point",[47,48],21.76837,39.55493,{"lat":48,"lon":47},[51],{"name":38,"role":33,"phone":52,"phoneExt":22,"email":53},"+30 24310 23602","g-dnd@uth.gr",{"type":29,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"Vaios Svolos","Dietitian, Postdoctoral Researcher","100622160","acceptability-and-adherence-to-different-dosing-regimens-of-the-multistrain-probiotic-vivomixx-460-neo-9-in-adults-receiving-antibiotic-therapy-100622160",false,"NCT07380009","Acceptability and Adherence to Different Dosing Regimens of the Multistrain Probiotic Vivomixx® 460 Neo 9 in Adults Receiving Antibiotic Therapy.","Acceptability and Adherence to Different Dosing Regimens of the Multistrain Probiotic Vivomixx® 460 Neo 9 in Adults Receiving Antibiotic Therapy: a Randomized, Open-label Clinical Trial.","VIVOMIXX 460","Inclusion Criteria:\n\n* Men and women aged over 18 years\n* Initiation of oral antibiotic therapy lasting more than 3 days\n* History of diarrhea during previous antibiotic treatment\n* Eligible antibiotics include: (a) amoxicillin with clavulanic acid, (b) clindamycin, and (c) second- or third-generation cephalosporins\n* Willingness to provide informed consent to participate in the study\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Age under 18 years\n* Diagnosis of a chronic autoimmune disease (e.g., Crohn's disease, ulcerative colitis, rheumatoid arthritis, psoriasis)\n* Diagnosis of type I or type II diabetes\n* Renal or hepatic disease\n* Current use of immunosuppressive medications\n* Current use of other supplements, probiotics, prebiotics, or synbiotics\n* Use of antibiotics within the past month\n* Use of laxatives or antidiarrheal medications within the past 2 weeks\n* Pre-existing diarrhea within the past 2 weeks\n* Self-reported allergy to any component of the probiotic\n* Psychological conditions affecting the ability to provide informed consent (e.g., dementia, psychosis, substance use)\n* Gastrointestinal surgery within the past 6 months","ALL","18 Years",{"count":68,"type":69},40,"ESTIMATED","INTERVENTIONAL",[72],"NA","This open-label interventional study aims to evaluate the acceptability and adherence of adult participants to the multistrain probiotic Vivomixx® 460 Neo 9 when administered concurrently with antibiotic therapy. Participants are randomized to receive one of two dosing regimens: a low daily dose or a high daily dose. The study will assess the effects of these regimens on the prevention of antibiotic-associated diarrhea (AAD), gastrointestinal symptoms, and patient adherence and acceptability. The results are intended to provide evidence to optimize the clinical use of probiotics alongside antibiotics.",[75],"Antibiotic Therapy",[77,78,79],"antibiotic","probiotic","vivomixx","2026-01-23",{"date":82,"type":83},"2026-02-02","ACTUAL",{"date":85,"type":83},"2025-12-12",{"date":87,"type":69},"2026-05-30",{"name":5,"class":6},1]