[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635114":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":36,"locations":41,"responsibleParty":60,"collaborators":26,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":26,"enrollmentInfo":72,"targetDuration":26,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":84,"overallStatus":88,"whyStopped":26,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Dana-Farber Cancer Institute","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm AVE: Acupuncture + Virtual Exercise","EXPERIMENTAL","25 participants will complete:\n\n* In-clinic baseline visit\n* 3 exercise sessions with certified trainer per week\n* 1 in-clinic acupuncture session per week\n* One or two end of study in-clinic visits",[13,14],"Procedure: Acupuncture","Behavioral: Exercise",{"label":16,"type":17,"description":18,"interventionNames":19},"Arm VE: Virtual Exercise","ACTIVE_COMPARATOR","25 participants will complete:\n\n* In-clinic baseline visit\n* 3 exercise sessions with certified trainer per week\n* One or two end of study in-clinic visits",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Acupuncture","Acupuncture treatment with licensed acupuncturist.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"BEHAVIORAL","Exercise","Virtually supervised, technology-based aerobic and resistance exercise program. Exercise bike and resistance bands will be provided to participants. Exercise sessions will be via HIPAA-compliant, teleconference platform Zoom.",[9,16],[33],{"name":34,"affiliation":5,"role":35},"Christina Dieli-Conwright, PhD, MPH","PRINCIPAL_INVESTIGATOR",[37],{"name":34,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","617-582-8321","ChristinaM_Dieli-Conwright@dfci.harvard.edu",[42],{"facility":43,"status":26,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Dana Farber Cancer Institute","Boston","Massachusetts","02215","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-71.05977,42.35843,{"lat":53,"lon":52},[56,58],{"name":34,"role":38,"phone":57,"phoneExt":26,"email":40},"617-632-3800",{"name":59,"role":35,"phone":26,"phoneExt":26,"email":26},"Christina Dieli-Conwright, PhD",{"type":35,"investigatorFullName":59,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Principal Investigator","100635114","acupuncture-and-exercise-for-ev-pembro-induced-peripheral-neuropathy-100635114",false,"NCT07548476","Acupuncture and Exercise for EV-Pembro-Induced Peripheral Neuropathy","Acupuncture and Exercise for EV-Pembro-Induced Peripheral Neuropathy (ACE)","ACE","Inclusion Criteria:\n\n* Age ≥ 18 years old\n* Diagnosed with pathologically proven advanced or metastatic urothelial cancer (mUC)\n* Planning to receive treatment with EV-Pembro or have received up to two cycles of EV-Pembro treatment with enrollment occurring prior to the start of the third cycle\n* Self-reported ability to walk for 6 minutes and\u002For 2 blocks\n* Deemed acceptable for exercise by their treating provider\n* Sedentary, currently engaging in less than or equal to 60 minutes of moderate or vigorous structured exercise\u002Fweek, as assessed by the Godin Leisure-Time Exercise Questionnaire\n* Willing to adhere to all study-related procedures, including randomization to one of the two possible acupuncture treatments\n* Eligible per verbally administered Physical Activity Readiness Questionnaire (PAR-Q+)\n* Referrals to physical therapy are allowed during the study if necessary; and\n* Participants taking any of medications listed below must be on a stable regimen, with no changes in the past three months. Use of these medications may continue while on study.\n* Duloxetine, amitriptyline, nortriptyline, gabapentin, and pregabalin\n\nExclusion Criteria:\n\n* History of peripheral neuropathy prior to EV-Pembro initiation\n* Patients with a pacemaker or other electronically charged medical device; or\n* Participate in more than 60 minutes of moderate or vigorous structured exercise\u002Fweek\n\nInvestigators will not include the following special populations:\n\n* Adults unable to consent\n* Individuals who are not yet adults (infants, children, teenagers \\\u003C 18 years)\n* Pregnant women\n* Prisoners","ALL","18 Years",{"count":73,"type":74},50,"ESTIMATED","INTERVENTIONAL",[77],"NA","The goal of this study is to evaluate the feasibility and preliminary efficacy of a combined acupuncture and exercise intervention for the management of chemotherapy-induced peripheral neuropathy (CIPN) in participants with metastatic bladder cancer receiving enfortumab vedotin (EV) and pembrolizumab (Pembro).\n\nThe names of the two study groups in this research study are:\n\n* Acupuncture + Virtual Exercise (AVE)\n* Virtual Exercise Only (VE)",[80,81,82,83],"Metastatic Bladder Cancer","Peripheral Neuropathy","Advanced Urothelial Cancer","Metastatic Urothelial Cancer",[85,86,87],"Enfortumab Vedotin-Induced Neuropathy","Pembrolizumab-Induced Neuropathy","mUC","NOT_YET_RECRUITING","2026-04-28",{"date":91,"type":92},"2026-05-04","ACTUAL",{"date":94,"type":74},"2026-10-02",{"date":96,"type":74},"2027-03-02",{"name":5,"class":6},1]