[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100480017":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":33,"centralContacts":37,"locations":44,"responsibleParty":87,"collaborators":89,"id":93,"slug":94,"hasResults":95,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":42,"eligibilityCriteria":99,"healthyVolunteers":95,"sex":100,"minAge":101,"maxAge":102,"enrollmentInfo":103,"targetDuration":42,"studyType":106,"phases":107,"briefSummary":109,"conditions":110,"keywords":112,"overallStatus":47,"whyStopped":42,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"University of California, Irvine","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Anti-inflammatory EA (AI-EA)","EXPERIMENTAL","Anti-inflammatory electroacupuncture therapy",[13],"Other: electroacupuncture",{"label":15,"type":10,"description":16,"interventionNames":17},"Sympathoinhibitory EA (SI-EA)","sympatho-inhibitory electroacupuncture therapy",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Combined EA (cEA)","combination of SI-EA and AI-EA",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Control EA (Sham-EA)","Sham electroacupuncture",[13],[27],{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"electroacupuncture","acupuncture needling and stimulation are applied for 30 min",[9,19,23,15],[32],"acupuncture",[34],{"name":35,"affiliation":5,"role":36},"Shaista Malik","PRINCIPAL_INVESTIGATOR",[38],{"name":39,"role":40,"phone":41,"phoneExt":42,"email":43},"Ashwini Erande","CONTACT","7144567025",null,"aerande@hs.uci.edu",[45,74],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Susan Samueli Integrative Health Institute","RECRUITING","Irvine","California","92697","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-117.82311,33.66946,{"lat":57,"lon":56},[60,64,67,70,72],{"name":61,"role":40,"phone":62,"phoneExt":42,"email":63},"Mitchell Beasley, MD, PhD, MPH","949-824-7000","beasleym@uci.edu",{"name":65,"role":40,"phone":62,"phoneExt":42,"email":66},"Shaista Malik, PhD","smalik@hs.uci.edu",{"name":68,"role":69,"phone":42,"phoneExt":42,"email":42},"LiFang Xie, PhD, LAc","SUB_INVESTIGATOR",{"name":71,"role":36,"phone":42,"phoneExt":42,"email":42},"Shaista Malik, MD, PhD, MPH",{"name":73,"role":36,"phone":42,"phoneExt":42,"email":42},"Stephanie Tjen-A-Looi, PhD",{"facility":75,"status":47,"city":76,"state":49,"zip":77,"country":51,"countryCode":52,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"University of California, Irvine, Health Sciences Medical Center","Orange","92868",{"type":54,"coordinates":79},[80,81],-117.85311,33.78779,{"lat":81,"lon":80},[84],{"name":85,"role":40,"phone":86,"phoneExt":42,"email":42},"Herlinda Bergman, M.Sc.","714-456-7090",{"type":36,"investigatorFullName":35,"investigatorTitle":88,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"Professor",[90],{"name":91,"class":92},"National Center for Complementary and Integrative Health (NCCIH)","NIH","100480017","acupuncture-therapy-and-hypertension-100480017",false,"NCT05530512","Acupuncture Therapy and Hypertension","Neuroimmune Mechanisms Underlying Electroacupuncture Effect on Vascular Function","Inclusion Criteria:\n\n1. Subjects from 45 to 75 years of age\n2. Clinically diagnosed with mild to moderate hypertension and ON or OFF medication (Office SBP \\> 140 mmHg and \\\u003C 160 mmHg Or ABPM average SBP \\> 130 mmHg and \\\u003C 145 mmHg), and\n3. No significant ECG change reflecting ischemia (i.e. ST elevation or depression) at rest will be recruited to participate in this study.\n\nExclusion Criteria:\n\n1. Subjects will be excluded if pregnant or nursing.\n2. Subjects will be excluded if they have coronary disease (by history or on ECG screening), conduction abnormalities on ECG consistent with left bundle branch block, cardiac arrhythmias associated with low blood pressure (\\\u003C90 mmHg), peripheral vascular disease, orthopedic disease, diabetic neuropathy or severe hypertension (BP \\>170 mmHg systolic or \\>110 mmHg diastolic), or any other physical or psychological illness.\n3. Those with known sensitivity to any topical preparations or strong reactions to medical dressings and skin tapes also will be excluded.\n4. Inability our or unwillingness of individual to give written informed consent.","ALL","45 Years","75 Years",{"count":104,"type":105},72,"ESTIMATED","INTERVENTIONAL",[108],"NA","Acupuncture therapy will be provided to reduce blood pressure in hypertensive patients. The mild to moderate hypertensive patients will be either on or off hypertensive medications. The course last for 8 weeks and the frequency is once a week.",[111],"Mild to Moderate Hypertension",[113],"hypertension, electroacupuncture","2025-07-16",{"date":116,"type":117},"2025-07-20","ACTUAL",{"date":119,"type":117},"2023-01-01",{"date":121,"type":105},"2027-03-31",{"name":5,"class":6},2]