[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100579924":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":10,"responsibleParty":34,"collaborators":10,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":40,"acronym":41,"eligibilityCriteria":42,"healthyVolunteers":38,"sex":43,"minAge":44,"maxAge":45,"enrollmentInfo":46,"targetDuration":10,"studyType":49,"phases":10,"briefSummary":50,"conditions":51,"keywords":53,"overallStatus":59,"whyStopped":10,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":10},{"fullName":5,"class":6},"NHS Greater Glasgow and Clyde","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients who have completely recovered from concussion",null,"Recovery from concussion will be assessed at 25 +\u002F- 3 days using a validated symptom score, the Post Concussion Symptom Scale (PCSS). This group will have a PCSS = 0.",[13],"Diagnostic Test: 7T MRI brain",{"label":15,"type":10,"description":16,"interventionNames":17},"Patients who have ongoing symptoms from concussion","Recovery from concussion will be assessed at 25 +\u002F- 3 days using a validated symptom score, the Post Concussion Symptom Scale (PCSS). This group will have a PCSS \\> 10.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","7T MRI brain","A very detailed MRI scan of the brain using a 7T MRI scanner.",[9,15],[25,30],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Prof Stewart","CONTACT","(0141) 354 9535","william.stewart@glasgow.ac.uk",{"name":31,"role":27,"phone":32,"phoneExt":10,"email":33},"Prof Lowe","(0141) 452 2932","david.lowe@glasgow.ac.uk",{"type":35,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100579924","acute-concussion-management-in-emergency-medicine-with-7t-mri-a-feasibility-study-100579924",false,"NCT06830616","Acute Concussion Management in Emergency Medicine with 7T MRI: a Feasibility Study","ACME-7T","Inclusion Criteria:\n\n1. Isolated head trauma\n2. Initial review within 96h of injury\n3. No acute findings on CT head\n4. Aged 18-40 years\n\nExclusion Criteria:\n\n1. Patient unable to give informed consent\n2. Patient unable to speak and understand English\n3. Patients where alternative diagnosis cannot be excluded\n4. Polytrauma\n5. Contra-indication to MRI\n6. BMI \\>40 or unable to comfortably lie on MRI scanner\n7. Pregnant\n8. Major confounding neurological disease e.g Multiple sclerosis, Stroke, Parkinson's Disease.\n9. Patient participation in other research studies concurrently","ALL","18 Years","40 Years",{"count":47,"type":48},20,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn about the brain imaging changes associated with concussion using a very detailed (7T) MRI scanner.\n\nTo do this, the investigators will study 7T MRI brain imaging in patients aged 18-40 who present to the Emergency Department within 96 hours of a head injury. Patients will be eligible if they have had a normal CT brain as part of their usual care.\n\nThe investigators will compare brain imaging from patients who have completely recovered from an episode of concussion to patients who still have significant symptoms at approximately 28 days after a head injury.\n\nThe study attempts to answer the following questions:\n\n1. Do patients with ongoing symptoms after concussion show greater 7T MRI brain imaging evidence of changes to the blood vessels at approximately 28 days after their injury in comparison to patients who have recovered fully?\n2. Do patients with ongoing symptoms after concussion show greater 7T MRI brain imaging evidence of changes in brain signaling pathways at approximately 28 days after their injury, in comparison to patients who have recovered fully?",[52],"Traumatic Brain Injury (TBI); Concussion, Initial Encounter",[54,55,56,57,58],"concussion","7T MRI","head injury","mildTBI","MRI brain","NOT_YET_RECRUITING","2025-02-18",{"date":62,"type":63},"2025-02-20","ACTUAL",{"date":65,"type":48},"2025-02",{"date":67,"type":48},"2025-11",{"name":5,"class":6}]