[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616036":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":60,"collaborators":25,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":25,"eligibilityCriteria":69,"healthyVolunteers":66,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":25,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":39,"whyStopped":25,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Valencia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise to failure under low load resistance with moderate blood occlusion and dynamic pressure.","EXPERIMENTAL","A single exercise session to failure, 30% of maximum repetition, 50% blood occlusion and dynamic pressure.",[13],"Device: Low-intensity resistance exercise to failure with moderate arterial occlusion pressure and dynamic pressure.",{"label":15,"type":10,"description":16,"interventionNames":17},"Exercise to failure under low load resistance with moderate blood occlusion and fixed pressure.","A single exercise session to failure, 30% of maximum repetition, 50% blood occlusion and fixed pressure.",[18],"Device: Low-intensity resistance exercise to failure with moderate arterial occlusion pressure and fixed pressure.",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Low-intensity resistance exercise to failure with moderate arterial occlusion pressure and dynamic pressure.","A single quadriceps extension exercise at 30% of 1 repetition maximum (1RM) with dynamic occlusion at 50% of limb occlusion pressure (LOP). The exercise protocol will consist of 4 sets to muscle failure with 30 seconds of rest between sets and a continuous level of occlusion.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Low-intensity resistance exercise to failure with moderate arterial occlusion pressure and fixed pressure.","A single quadriceps extension exercise at 30% of 1 repetition maximum (1RM) with fixed occlusion at 50% of limb occlusion pressure (LOP). The exercise protocol will consist of 4 sets to muscle failure with 30 seconds of rest between sets and a continuous level of occlusion.",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Adrián Escriche-Escuder, PhD","CONTACT","+34 963 98 38 55","adrian.escriche@uv.es",[37,56],{"facility":38,"status":39,"city":40,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Faculty of Physiotherapy, University of Valencia","RECRUITING","Valencia","46010","Spain","ES",{"type":45,"coordinates":46},"Point",[47,48],-0.37966,39.47391,{"lat":48,"lon":47},[51,53],{"name":52,"role":33,"phone":34,"phoneExt":25,"email":35},"Adrian Escriche-Escuder, PhD",{"name":54,"role":55,"phone":25,"phoneExt":25,"email":25},"Ignacio Coscollà-Agramunt, MSc","SUB_INVESTIGATOR",{"facility":5,"status":39,"city":40,"state":40,"zip":25,"country":42,"countryCode":43,"cosmosGeoPoint":57,"geoPoint":59,"contacts":25},{"type":45,"coordinates":58},[47,48],{"lat":48,"lon":47},{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Adrián Escriche Escuder","Assistant professor","100616036","acute-effects-of-blood-flow-restriction-training-to-failure-on-hypoalgesia-in-patients-with-severe-knee-osteoarthritis-using-dynamic-or-fixed-occlusion-pressure-100616036",false,"NCT07300384","Acute Effects of Blood Flow Restriction Training to Failure on Hypoalgesia in Patients With Severe Knee Osteoarthritis Using Dynamic or Fixed Occlusion Pressure","Inclusion Criteria:\n\n* Age between 50 and 85 years\n* Diagnosis of severe gonarthrosis according to the clinical and radiographic criteria of the American College of Rheumatology guidelines.\n* On the waiting list for unilateral total knee replacement (TKR) surgery\n\nExclusion Criteria:\n\n* Pain in the contralateral leg with an intensity ≥80\u002F100 mm on the visual analog scale (VAS) during daily activities.\n* Previous hip or knee replacement surgery and osteotomy within the last year.\n* Autoimmune arthritis\n* Medical conditions that contraindicate exercise.\n* Participation in exercise programs (\\>2 days\u002Fweek with training at intensities of 10-15 1RM) in the previous six months.\n* History of stroke, brain surgery, major depression, or self-reported cognitive impairment that could affect performance in the study.\n* Cardiovascular, thrombotic, or vascular risk factors (uncontrolled hypertension, peripheral arterial disease, history of deep vein thrombosis or pulmonary embolism, heart failure, severe varicose veins, or uncontrolled anticoagulant therapy).\n* Skin or local alterations at the cuff application site (ulcers, open wounds, infections, lymphedema, or severe edema).\n* Inability to communicate normally or with impaired communication skills.","ALL","50 Years","85 Years",{"count":74,"type":75},45,"ESTIMATED","INTERVENTIONAL",[78],"NA","This study aims to compare the acute effects on hypoalgesia of training to failure using blood flow restriction (BFR) with dynamic occlusion versus BFR with fixed occlusion in patients with severe gonarthrosis. Two different training conditions will be performed with varying levels of blood flow occlusion (%BFR) and percentage of load (%RM): 1) 30% RM and 50% BFR with dynamic pressure; 2) 30% RM and 50% BFR with fixed pressure. Each participant will complete two individual sessions under different training conditions, randomly assigned with a 72-hour interval between sessions.",[81],"Severe Knee Osteoarthritis",[83,84,85],"bood flow restriction","exercise","gonarthrosis","2026-06-08",{"date":88,"type":89},"2026-06-10","ACTUAL",{"date":91,"type":89},"2026-02-25",{"date":93,"type":75},"2027-12",{"name":5,"class":6},2]