[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100566226":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":31,"locations":39,"responsibleParty":59,"collaborators":23,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":23,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":23,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":42,"whyStopped":23,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Fudan University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Low temperature (15°C) group","EXPERIMENTAL","Subjects in exposure group will be exposed to low temperature (15°C) for about 2 hours in a chamber.",[13],"Other: Low temperature (15°C) group",{"label":15,"type":10,"description":16,"interventionNames":17},"Moderate temperature (22°C) group","Subjects in exposure group will be exposed to moderate temperature (22°C) for about 2 hours in a chamber.",[18],"Other: Moderate temperature (22°C) group",[20,24],{"type":6,"name":9,"description":21,"armGroupLabels":22,"otherNames":23},"The exposure group will be exposed to low temperature (15°C) in a chamber for about 2 hours, resting during the whole periods.",[9],null,{"type":6,"name":15,"description":25,"armGroupLabels":26,"otherNames":23},"The exposure group will be exposed to thermoneutral temperature (22°C) in a chamber for about 2 hours, resting during the whole periods.",[15],[28],{"name":29,"affiliation":5,"role":30},"Haidong Kan, PhD","STUDY_DIRECTOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":23,"email":36},"Renjie Chen, PhD","CONTACT","+86-021-54237908","chenrenjie@fudan.edu.cn",{"name":29,"role":34,"phone":35,"phoneExt":23,"email":38},"kanh@fudan.edu.cn",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Department of Environmental Health, School of Public Health, Fudan University","RECRUITING","Shanghai","Shanghai Municipality","200032","China","CN",{"type":49,"coordinates":50},"Point",[51,52],121.45806,31.22222,{"lat":52,"lon":51},[55,56,57],{"name":29,"role":34,"phone":35,"phoneExt":23,"email":38},{"name":33,"role":34,"phone":35,"phoneExt":23,"email":36},{"name":33,"role":58,"phone":23,"phoneExt":23,"email":23},"PRINCIPAL_INVESTIGATOR",{"type":58,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Renjie Chen","Professor","100566226","acute-effects-of-cold-exposure-on-cardiovascular-system-100566226",false,"NCT06652425","Acute Effects of Cold Exposure on Cardiovascular System","Acute Effects of Cold Exposure on Cardiovascular System and Potential Mechanism in Healthy Young Adults: A Randomized Controlled Study","Inclusion Criteria:\n\n* Living in Shanghai during the study period;\n* Body mass index \\> 18.5 and ≤ 28;\n* Right-handed;\n* Receiving or having received higher education;\n* With the ability to read and understand Chinese smoothly.\n\nExclusion Criteria:\n\n* Smoking and alcohol abuse;\n* Current drug and dietary supplements intake;\n* Subjects with allergic diseases, such as allergic rhinitis, allergic asthma, and atopy;\n* Subjects with cardiovascular diseases, such as congenital heart disease, pulmonary heart disease, and hypertension;\n* Subjects with respiratory diseases, such as asthma, chronic bronchitis, and chronic obstructive pulmonary disease;\n* Subjects with chronic diseases, such as diabetes, chronic hepatitis, and kidney disease;\n* Subjects who have a history of major surgery due to cardiovascular, cerebrovascular, respiratory, or neurological diseases;\n* Subjects with neurologic disorders, such as stroke, traumatic brain injury, epilepsy, and schizophrenia;\n* Abnormal spirometry (FEV1 and FVC ≤ 75% of predicted and FEV1\u002FFVC ≤ 0.65);\n* Subjects with color vision disabilities.",true,"ALL","18 Years","30 Years",{"count":74,"type":75},40,"ESTIMATED","INTERVENTIONAL",[78],"NA","This is a randomized controlled human exposure crossover study. Investigators aim to assess the acute effects of low temperature exposure on cardiovascular system and the underlying mechanisms.",[81],"Cardiovascular System",[83,84,85],"Low temperature","Randomized controlled trial","Cardiovascular system","2025-02-25",{"date":88,"type":89},"2025-02-27","ACTUAL",{"date":91,"type":89},"2024-10-16",{"date":93,"type":75},"2026-12-31",{"name":5,"class":6},1]