[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100370068":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":11,"locations":26,"responsibleParty":61,"collaborators":11,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":11,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":11,"overallStatus":29,"whyStopped":11,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"University of Athens","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Diesel Exposure","EXPERIMENTAL",null,[13],"Behavioral: Diesel exhaust",{"label":15,"type":16,"description":11,"interventionNames":17},"Filtered Air Exposure","PLACEBO_COMPARATOR",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","Diesel exhaust","Exposure to diesel exhaust fumes",[9,15],[25],"Filtered air exposure",[27,47],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"1st Cardiology Department, Hippokration General Hospital","RECRUITING","Athens","Attica","11528","Greece","GR",{"type":36,"coordinates":37},"Point",[38,39],23.72784,37.98376,{"lat":39,"lon":38},[42],{"name":43,"role":44,"phone":45,"phoneExt":11,"email":46},"Manina Anastasopoulou","CONTACT","+2132088026","manastas@med.uoa.gr",{"facility":48,"status":29,"city":30,"state":49,"zip":50,"country":33,"countryCode":34,"cosmosGeoPoint":51,"geoPoint":53,"contacts":54},"Evangelos Oikonomou","Please Select","17122",{"type":36,"coordinates":52},[38,39],{"lat":39,"lon":38},[55,59],{"name":56,"role":44,"phone":57,"phoneExt":11,"email":58},"Evangelos Oikonomou, MD","+306947701299","boikono@gmail.com",{"name":60,"role":44,"phone":45,"phoneExt":11,"email":46},"Dimitris Tousoulis, MD, PhD",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Dimitris Tousoulis","Professor Dimitris Tousoulis","100370068","acute-exposure-to-diesel-prolong-effects-on-inflammation-and-vasculature-100370068",false,"NCT04098536","Acute Exposure to Diesel: Prolong Effects on Inflammation and Vasculature","DEVA","Inclusion Criteria:\n\n* Healthy subjects\n\nExclusion Criteria:\n\n* Chronic diseases Cardiovascular diseases Respiratory diseases Pregnacy",true,"ALL","18 Years","60 Years",{"count":77,"type":78},40,"ESTIMATED","INTERVENTIONAL",[81],"NA","Cross-over double-blind study. Healthy subjects will be exposed to diesel exhaust fumes and\u002For filtered air during a 2-hour session. Several parameters will be assesed i.e. endothelial function will be assessed with flow mediated dilation (FMD) techniques, arterial stiffness with pulse wave velocity (PWV) and reflected waves with augmentation index (AIx). C reactive protein (CRP), fibrinogen, protein C levels and protein S activity will be also measured. Heart rate variability and standard deviation of normal to normal intervals R-R intervals (SDNN) will be used to assess sympathetic activity. Measurements were assessed before, 2 and 24 hours after diesel exposure.",[84],"Atherosclerosis","2019-09-21",{"date":87,"type":88},"2019-09-24","ACTUAL",{"date":90,"type":88},"2015-01-01",{"date":92,"type":78},"2026-12-31",{"name":5,"class":6},2]