[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643930":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":12,"centralContacts":12,"locations":25,"responsibleParty":47,"collaborators":12,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":12,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":12,"enrollmentInfo":58,"targetDuration":12,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":12,"overallStatus":66,"whyStopped":12,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group","NO_INTERVENTION","Except for not undergoing ANH, other care managements are the same as the experimental group",null,{"label":14,"type":15,"description":16,"interventionNames":17},"ANH group","EXPERIMENTAL","Patients in the ANH group had whole blood withdrawn after induction of anesthesia. Meanwhile, patients receive colloid solution according to the volume of blood withdrawn.",[18],"Procedure: Acute Normovolemic Hemodilution",[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":12},"PROCEDURE","Acute Normovolemic Hemodilution","The whole blood is withdrawn after induction of anesthesia. Blood is withdrawn from a large-bore catheter and stored in blood bags. Meanwhile, patients receive colloid solution according to the volume of blood withdrawn.",[14],[26],{"facility":27,"status":12,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"The Second Affiliated Hospital of Zhejiang University anesthesiology department","Hangzhou","Zhejiang","310000","China","CN",{"type":34,"coordinates":35},"Point",[36,37],120.16142,30.29365,{"lat":37,"lon":36},[40,45],{"name":41,"role":42,"phone":43,"phoneExt":12,"email":44},"Min Yan, Doctor","CONTACT","+86 15888210247","zryanmin@zju.edu.cn",{"name":41,"role":46,"phone":12,"phoneExt":12,"email":12},"PRINCIPAL_INVESTIGATOR",{"type":48,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR","100643930","acute-normovolemic-hemodilution-in-bone-cancer-surgery-100643930",false,"NCT07669155","Acute Normovolemic Hemodilution in Bone Cancer Surgery","The Effect of Acute Normovolemic Hemodilution on Requirement of Allogeneic Red Blood Cell in Patients Undergoing Bone Cancer Surgery","Inclusion Criteria:\n\n1. age 18 more than years;\n2. undergoing elective bone cancer resection surgery;\n3. preoperative hemoglobin ≥12 g\u002FdL;\n\nExclusion Criteria:\n\n1. using a tourniquet;\n2. BMI\\\u003C18.5 Kg\u002Fm\\^2;\n3. international normalized ratio (INR) \\>1.5 or platelet count \\\u003C100 × 10\\^9\u002FL;\n4. cardiopulmonary insufficiency;\n5. hepatic and renal dysfunction;\n6. active infectious disease;\n7. allergy to colloid solution;\n8. pregnancy;\n9. declined participation in the study or declined blood transfusion","ALL","18 Years",{"count":59,"type":60},420,"ESTIMATED","INTERVENTIONAL",[63],"NA","Malignant bone tumors often lead to skeletal complications, known as skeletal related events (SRE). These complications mainly include pathological fractures, severe pain, and spinal cord compression. Typically, SRE reduces overall survival rates and is associated with loss of mobility and social functioning, decreased quality of life, and significantly increased healthcare costs. Surgical resection is an important means of treating malignant bone tumors. The main goal of surgical treatment is to maintain the patient's function and mobility by relieving pain, preventing impending fractures and\u002For nerve compression, or stabilizing pathological fractures. Surgery for malignant bone tumors often requires extensive exploration, osteotomy, and prosthetic reconstruction. The surgery involves significant trauma and excessive bleeding from the wound. Therefore, there is a significant risk of perioperative blood loss and transfusion during surgery for malignant bone tumors. However, blood transfusion also brings transfusion related risks to patients, increases the incidence of postoperative complications, and increases the healthcare burden on patients and society. Acute normovolemic hemodilution (ANH) may help reduce allogeneic red blood cell transfusion. However, There is a lack of high-quality evidence to support the use of ANH in bone cancer surgery.",[22],"NOT_YET_RECRUITING","2026-06-22",{"date":69,"type":70},"2026-06-25","ACTUAL",{"date":72,"type":60},"2026-07",{"date":74,"type":60},"2028-05",{"name":5,"class":6},1]