[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577501":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":52,"centralContacts":56,"locations":64,"responsibleParty":93,"collaborators":95,"id":99,"slug":100,"hasResults":101,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":101,"sex":107,"minAge":108,"maxAge":32,"enrollmentInfo":109,"targetDuration":32,"studyType":112,"phases":113,"briefSummary":115,"conditions":116,"keywords":118,"overallStatus":67,"whyStopped":32,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":130},{"fullName":5,"class":6},"Yale University","OTHER",[8,17,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Optimization Phase, Stage1: Factorial Trial","EXPERIMENTAL","Successful completion of Optimization Phase, Stage 1 Successful completion of the 2x2x2 factorial trial in which investigators expand EMBED to include sustainable implementation strategies: nurse prompt for withdrawal assessment, and targeted clinician prompt to use the CDS along with patient resources to promote equity and motivate readiness to start treatment.",[13,14,15,16],"Other: EMBED CDS","Other: Nurse prompt to complete COWS","Other: Provider Prompt","Other: Patient facing materials",{"label":18,"type":10,"description":19,"interventionNames":20},"Optimization Phase, Stage 2: Rapid serialized testing","Successful completion of Optimization Phase, Stage 2: Improve CDS usability via serial randomized testing to inform iterative refinement of the CDS interface and workflow to minimize user errors, task disruption, and abandonment through identification of specific targets for improvement via application of novel CDS outcome measures in serial randomized tests.",[13,21],"Other: Name of Intervention",{"label":23,"type":10,"description":24,"interventionNames":25},"Evaluation Phase","Successful completion of the Evaluation phase: Investigators will conduct a randomized trial to compare the efficacy of the optimized package compared to the original on ED-initiation of buprenorphine rates in patients with OUD.",[13,26],"Other: Optimized EMBED",[28,33,36,40,44,48],{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"EMBED CDS","EMBED is a user user-centered, clinician clinician-facing clinical decision support system integrated into the electronic health record workflow to facilitate initiating buprenorphine in the emergency department by: diagnosing opioid use disorder with a checklist based on the diagnostic criteria of the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, fifth edition), assessing the severity of withdrawal with the Clinical Opioid Withdrawal Scale (COWS), motivating patients to accept treatment with a scripted brief negotiation interview, and automating the electronic health record workflow, including clinical and after visit documentation, order entry, prescribing, and referral for ongoing treatment in the community.\n\nIntervention to be informed by CDS measurement and user feedback during the factorial trial phase (Optimization Phase, Stage 1)",[23,18,9],null,{"type":6,"name":34,"description":34,"armGroupLabels":35,"otherNames":32},"Nurse prompt to complete COWS",[9],{"type":6,"name":37,"description":38,"armGroupLabels":39,"otherNames":32},"Provider Prompt","Provider Prompt to use EMBED: EMBED is a user user-centered, clinician clinician-facing clinical decision support system integrated into the electronic health record workflow to facilitate initiating buprenorphine in the emergency department by: diagnosing opioid use disorder with a checklist based on the diagnostic criteria of the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, fifth edition), assessing the severity of withdrawal with the Clinical Opioid Withdrawal Scale (COWS), motivating patients to accept treatment with a scripted brief negotiation interview, and automating the electronic health record workflow, including clinical and after visit documentation, order entry, prescribing, and referral for ongoing treatment in the community. Intervention to be informed by CDS measurement and user feedback during the factorial trial phase (Optimization Phase, Stage 1)",[9],{"type":6,"name":41,"description":42,"armGroupLabels":43,"otherNames":32},"Patient facing materials","Provider prompt to give patient customized discharge instructions directing patient to resources matched to their needs.",[9],{"type":6,"name":45,"description":46,"armGroupLabels":47,"otherNames":32},"Optimized EMBED","CDS following Optimization Phase, Stage 2: Rapid serialized testing",[23],{"type":6,"name":49,"description":50,"armGroupLabels":51,"otherNames":32},"Name of Intervention","Intervention to be informed by results during Evaluation Phase, Stage 1 and will involve refinement of user interface and workflows for the EMBED CDS: EMBED is a user user-centered, clinician clinician-facing clinical decision support system integrated into the electronic health record workflow to facilitate initiating buprenorphine in the emergency department by: diagnosing opioid use disorder with a checklist based on the diagnostic criteria of the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, fifth edition), assessing the severity of withdrawal with the Clinical Opioid Withdrawal Scale (COWS), motivating patients to accept treatment with a scripted brief negotiation interview, and automating the electronic health record workflow, including clinical and after visit documentation, order entry, prescribing, and referral for ongoing treatment in the community.",[18],[53],{"name":54,"affiliation":5,"role":55},"Edward Melnick, MD, MHS","PRINCIPAL_INVESTIGATOR",[57,61],{"name":54,"role":58,"phone":59,"phoneExt":32,"email":60},"CONTACT","203-785-4363","edward.melnick@yale.edu",{"name":62,"role":58,"phone":32,"phoneExt":32,"email":63},"Laurel Buchanan","laurel.buchanan@yale.edu",[65,79,88],{"facility":66,"status":67,"city":68,"state":69,"zip":70,"country":71,"countryCode":72,"cosmosGeoPoint":73,"geoPoint":78,"contacts":32},"Yale New Haven Shoreline Medical Center","RECRUITING","Guilford","Connecticut","06437","United States","US",{"type":74,"coordinates":75},"Point",[76,77],-72.68176,41.28899,{"lat":77,"lon":76},{"facility":80,"status":67,"city":81,"state":69,"zip":82,"country":71,"countryCode":72,"cosmosGeoPoint":83,"geoPoint":87,"contacts":32},"Yale New Haven Hospital- St. Raphael","New Haven","06510",{"type":74,"coordinates":84},[85,86],-72.92816,41.30815,{"lat":86,"lon":85},{"facility":89,"status":67,"city":81,"state":69,"zip":82,"country":71,"countryCode":72,"cosmosGeoPoint":90,"geoPoint":92,"contacts":32},"Yale New Haven Hospital",{"type":74,"coordinates":91},[85,86],{"lat":86,"lon":85},{"type":94,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR",[96],{"name":97,"class":98},"National Institute on Drug Abuse (NIDA)","NIH","100577501","adaptive-decision-support-for-addiction-treatment-master-100577501",false,"NCT06799117","Adaptive Decision Support for Addiction Treatment Master","Adaptive Decision Support for Addiction Treatment (ADAPT)","ADAPT","Inclusion Criteria:\n\n* Emergency department patient\n* 18 years of age or older\n* Moderate to severe opioid use disorder\n\nExclusion Criteria:\n\n* Under 18 years of age\n* Pregnant\n* Currently receiving medication for opioid use disorder","ALL","18 Years",{"count":110,"type":111},1912,"ESTIMATED","INTERVENTIONAL",[114],"NA","This study refines and optimizes the EMBED\\* clinical decision support (CDS; see NCT03658642) to increase number of ED physicians following standard of care for the administration of buprenorphine to appropriate patients with opioid use disorder.\n\nThis study does not have open enrollment. Investigators will use a Multiphase Optimization STrategy (MOST) framework study with preparation, optimization, and confirmatory phases.\n\nOptimization Phase: This phase has two stages. In stage 1, investigators will conduct a 2x2x2 factorial trial to expand EMBED is expanded to include sustainable implementation strategies: nurse prompt for withdrawal assessment, and targeted clinician prompts to use the CDS along with individualized patient resources to promote equity and motivate readiness to start treatment. In Stage 2, investigators will improve CDS usability via serial randomized testing to inform iterative refinement of the CDS interface and workflow to minimize user errors, task disruption, and abandonment through identification of specific targets for improvement via application of novel CDS outcome measures in serial randomized tests.\n\nEvaluation phase: Investigators will conduct a randomized trial to compare the efficacy effectiveness of the optimized package compared to the original on ED-initiation of buprenorphine rates in patients with OUD.\n\n\\*EMBED is a user user-centered, clinician clinician-facing clinical decision support system integrated into the electronic health record workflow to facilitate initiating buprenorphine in the emergency department by: diagnosing opioid use disorder with a checklist based on the diagnostic criteria of the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, fifth edition), assessing the severity of withdrawal with the Clinical Opioid Withdrawal Scale (COWS), motivating patients to accept treatment with a scripted brief negotiation interview, and automating the electronic health record workflow, including clinical and after visit documentation, order entry, prescribing, and referral for ongoing treatment in the community",[117],"Opioid Use Disorder",[119,120],"Opioid use disorder","Clinical Decision Support","2026-06-10",{"date":123,"type":124},"2026-06-11","ACTUAL",{"date":126,"type":124},"2025-03-21",{"date":128,"type":111},"2028-03-31",{"name":5,"class":6},3]