[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100448927":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":23,"locations":28,"responsibleParty":46,"collaborators":18,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":18,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":18,"overallStatus":30,"whyStopped":18,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Ann & Robert H Lurie Children's Hospital of Chicago","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Meal Replacement and Lifestyle Therapy","EXPERIMENTAL","Participants in this study will have an 8-week meal replacement therapy period in which they are asked to reduce their BMI by 5% by following a prescribed eating regimen consisting of meal replacement shakes and\u002For frozen meals for breakfast and lunch. For dinner they will consume a pre-packaged frozen entree to be consumed with two servings of fruit and three servings of vegetables per day. Participants will also have lifestyle\u002Fbehavioral modification counseling every 2 weeks throughout the entire study.",[13],"Other: Meal replacement and lifestyle modification",[15],{"type":6,"name":16,"description":16,"armGroupLabels":17,"otherNames":18},"Meal replacement and lifestyle modification",[9],null,[20],{"name":21,"affiliation":5,"role":22},"Justin Ryder, PhD","PRINCIPAL_INVESTIGATOR",[24],{"name":21,"role":25,"phone":26,"phoneExt":18,"email":27},"CONTACT","3148826838","jryder@luriechildrens.org",[29],{"facility":5,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"RECRUITING","Chicago","Illinois","60611","United States","US",{"type":37,"coordinates":38},"Point",[39,40],-87.65005,41.85003,{"lat":40,"lon":39},[43,45],{"name":44,"role":25,"phone":26,"phoneExt":18,"email":27},"Justin R Ryder",{"name":21,"role":22,"phone":18,"phoneExt":18,"email":18},{"type":22,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Justin Ryder","Vice Chair of Research for the Department of Surgery at Lurie Children's Hospital","100448927","adaptive-mechanisms-responsible-for-weight-change-in-youth-with-obesity-100448927",false,"NCT05125822","Adaptive Mechanisms Responsible for Weight Change in Youth With Obesity","ADMIRE","Inclusion Criteria:\n\n* 11 to less than 16 years old\n* BMI \\> 30 kg\u002Fm\\^2 or 95th BMI percentile\n* Tanner stage 2, 3, or 4\n\nExclusion Criteria:\n\n* Tanner stage 1 and 5\n* Prior bariatric surgery\n* Current or recent (\\\u003C 3 months prior to enrollment) use of anti-obesity medication(s) defined as orlistat, metformin, phentermine, topiramate, combination phentermine\u002Ftopiramate, liraglutide, and\u002For combination naltrexone\u002Fbupropion (monotherapy use of naltrexone or bupropion is not an exclusion)\n* Monogenic and hypothalamic obesity\n* Polycystic ovary syndrome (diagnosed by a physician)\n* Pregnancy or planned pregnancy\n* Current use of supplemental hormones\n* Individuals with a diagnosed eating disorder of anorexia nervosa, bulimia or binge eating disorder\n* Type 1 or 2 diabetes\n* Treatment with growth hormones\n* Thyroid disease\u002Fproblem\n* Has had cancer in the last 10 years","ALL","11 Years","15 Years",{"count":60,"type":61},260,"ESTIMATED","INTERVENTIONAL",[64],"NA","In this study, doctors want to find out more about why people who lose weight often regain the weight that they have lost once they resume a regular diet and whether hormones might play a role in weight regain. The study is divided into two parts, called the meal replacement period and the follow-up period. The meal replacement period will consist of drinking a shake for breakfast and lunch and eating a frozen meal for dinner that is calorie controlled. Individuals will also be asked to eat two servings of fruit and three servings of vegetables each day. The study will provide the shakes and the frozen entrees, participants are asked to supply the fruits and vegetables.\n\nParticipation in this study will last for up to 35 weeks. There will be 10 in-person visits and 13 visits by phone or over Zoom over the 35 weeks.",[67],"Childhood Obesity","2026-05-29",{"date":70,"type":71},"2026-06-02","ACTUAL",{"date":73,"type":71},"2023-08-26",{"date":75,"type":61},"2028-01-01",{"name":5,"class":6},1]