[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552429":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":241,"collaborators":18,"id":243,"slug":244,"hasResults":245,"nctId":246,"briefTitle":247,"officialTitle":247,"acronym":248,"eligibilityCriteria":249,"healthyVolunteers":245,"sex":250,"minAge":251,"maxAge":18,"enrollmentInfo":252,"targetDuration":18,"studyType":255,"phases":256,"briefSummary":258,"conditions":259,"keywords":262,"overallStatus":37,"whyStopped":18,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":271,"completionDateStruct":273,"leadSponsor":275,"locationsCount":276},{"fullName":5,"class":6},"University Hospital, Montpellier","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Interventional group","EXPERIMENTAL","Patients randomized into the interventional arm will participate in an addiction consultation during their hospital stay following LT. The participant's addiction treatment will be based on the number of risk factors identified.",[13],"Other: Post-transplant addiction intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","Participants randomized into the control arm will benefit from routine LT follow-up organized by the doctors and\u002For surgeons of the LT center during the post-transplant follow-up period. Usually, the patients have monthly outpatient visit with their physician during the first year after LT, then bi-monthly during the second year. At present, each center has a very different way of supporting transplant recipients, there is no systematic follow-up by an addictologist. Routine care at each center will be identified before the study set up. The different centers refer patients only after return to alcohol use is perceived in routine consultation or identified through biological alcohol markers. In this case, \"the alcohol relapse\" event will be noted and patients will be transferred to the addictologic center.",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":18},"Post-transplant addiction intervention","The first addiction consultation will be conducted using the BRENDA method which allows the addiction specialist to carry out a psychosocial assessment, to entrust the results of this assessment to the participant, to answer their questions and to evaluate their reactions. Risk factors for alcohol relapse will be collected: social determinants, male gender, psychiatric comorbidities, duration of alcohol abstinence before LT(≥ or \\\u003C 6 months) and young age (\\\u003C 40 years). If the addiction specialist notes the presence of at least 3 risk factors for alcohol relapse, targeted addiction follow-up will be proposed to the participant including outpatient consultations with motivational interview at least every 4 weeks +\u002F- pharmacological treatment of alcohol use disorder.In case of alcohol relapse or a period of high vulnerability to relapse, specific hospitalizations can be scheduled. If the participant has \\\u003C3 risk factors, an addictology consultation every 6 months at most will be proposed.",[9],[25],{"name":26,"affiliation":5,"role":27},"Hélène DONNADIEU, MD, PhD","PRINCIPAL_INVESTIGATOR",[29],{"name":26,"role":30,"phone":31,"phoneExt":32,"email":33},"CONTACT","0467337020","+33","h-donnadieu@chu-montpellier.fr",[35,53,64,75,86,97,110,123,143,156,169,179,189,204,217,228],{"facility":36,"status":37,"city":38,"state":18,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Besançon University Hospital","RECRUITING","Besançon","France","FR",{"type":42,"coordinates":43},"Point",[44,45],6.01815,47.24878,{"lat":45,"lon":44},[48,50],{"name":49,"role":27,"phone":18,"phoneExt":18,"email":18},"Claire VANLEMMENS",{"name":51,"role":52,"phone":18,"phoneExt":18,"email":18},"Julie GIUSTINIANI","SUB_INVESTIGATOR",{"facility":54,"status":37,"city":55,"state":18,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"Bordeaux University Hospital","Bordeaux",{"type":42,"coordinates":57},[58,59],-0.58046,44.84124,{"lat":59,"lon":58},[62],{"name":63,"role":27,"phone":18,"phoneExt":18,"email":18},"Faiza CHERMAK",{"facility":65,"status":37,"city":66,"state":18,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Clermont Ferrand University Hospital","Clermont-Ferrand",{"type":42,"coordinates":68},[69,70],3.08682,45.77969,{"lat":70,"lon":69},[73],{"name":74,"role":27,"phone":18,"phoneExt":18,"email":18},"Armand ABERGEL",{"facility":76,"status":37,"city":77,"state":18,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"Dijon University Hospital","Dijon",{"type":42,"coordinates":79},[80,81],5.01391,47.31344,{"lat":81,"lon":80},[84],{"name":85,"role":27,"phone":18,"phoneExt":18,"email":18},"Marianne LATOURNERIE",{"facility":87,"status":37,"city":88,"state":18,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":89,"geoPoint":93,"contacts":94},"Lille University Hospital","Lille",{"type":42,"coordinates":90},[91,92],3.05512,50.63391,{"lat":92,"lon":91},[95],{"name":96,"role":27,"phone":18,"phoneExt":18,"email":18},"Sebastien DHARANCY",{"facility":98,"status":37,"city":99,"state":18,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"Lyon University Hospital","Lyon",{"type":42,"coordinates":101},[102,103],4.84789,45.74906,{"lat":103,"lon":102},[106,108],{"name":107,"role":27,"phone":18,"phoneExt":18,"email":18},"Teresa ANTONINI",{"name":109,"role":52,"phone":18,"phoneExt":18,"email":18},"Olivier LEJEUNE",{"facility":111,"status":37,"city":112,"state":18,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":113,"geoPoint":117,"contacts":118},"Marseille University Hospital","Marseille",{"type":42,"coordinates":114},[115,116],5.38107,43.29695,{"lat":116,"lon":115},[119,121],{"name":120,"role":27,"phone":18,"phoneExt":18,"email":18},"Sophie CHOPINET",{"name":122,"role":52,"phone":18,"phoneExt":18,"email":18},"Christophe LANCON",{"facility":124,"status":37,"city":125,"state":18,"zip":126,"country":39,"countryCode":40,"cosmosGeoPoint":127,"geoPoint":131,"contacts":132},"Montpellier University Hospital","Montpellier","34000",{"type":42,"coordinates":128},[129,130],3.87635,43.61093,{"lat":130,"lon":129},[133,135,137,139,141],{"name":134,"role":27,"phone":18,"phoneExt":18,"email":18},"Hélène DONNADIEU",{"name":136,"role":27,"phone":18,"phoneExt":18,"email":18},"Georges Philippe PAGEAUX",{"name":138,"role":52,"phone":18,"phoneExt":18,"email":18},"Jose URSIC-BEDOYA",{"name":140,"role":52,"phone":18,"phoneExt":18,"email":18},"Stephanie FAURE",{"name":142,"role":52,"phone":18,"phoneExt":18,"email":18},"Lucy MEUNIER",{"facility":144,"status":37,"city":145,"state":18,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":146,"geoPoint":150,"contacts":151},"Nice University Hospital","Nice",{"type":42,"coordinates":147},[148,149],7.26608,43.70313,{"lat":149,"lon":148},[152,154],{"name":153,"role":27,"phone":18,"phoneExt":18,"email":18},"Rodolphe ANTY",{"name":155,"role":52,"phone":18,"phoneExt":18,"email":18},"Régine TRUCHI",{"facility":157,"status":37,"city":158,"state":18,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"APHP Mondor","Paris",{"type":42,"coordinates":160},[161,162],2.3488,48.85341,{"lat":162,"lon":161},[165,167],{"name":166,"role":27,"phone":18,"phoneExt":18,"email":18},"Christophe DUVOUX",{"name":168,"role":27,"phone":18,"phoneExt":18,"email":18},"Vincent 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Hospital","Rennes",{"type":42,"coordinates":193},[194,195],-1.67431,48.11109,{"lat":195,"lon":194},[198,200,202],{"name":199,"role":27,"phone":18,"phoneExt":18,"email":18},"Pauline HOUSSEL",{"name":201,"role":52,"phone":18,"phoneExt":18,"email":18},"Caroline LE LAN",{"name":203,"role":52,"phone":18,"phoneExt":18,"email":18},"Romain MOIRAND",{"facility":205,"status":37,"city":206,"state":18,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":207,"geoPoint":211,"contacts":212},"Strasbourg University Hospital","Strasbourg",{"type":42,"coordinates":208},[209,210],7.74553,48.58392,{"lat":210,"lon":209},[213,215],{"name":214,"role":27,"phone":18,"phoneExt":18,"email":18},"Camille BESCH",{"name":216,"role":52,"phone":18,"phoneExt":18,"email":18},"Anais LANG",{"facility":218,"status":37,"city":219,"state":18,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":220,"geoPoint":224,"contacts":225},"Toulouse University Hospital","Toulouse",{"type":42,"coordinates":221},[222,223],1.44367,43.60426,{"lat":223,"lon":222},[226],{"name":227,"role":27,"phone":18,"phoneExt":18,"email":18},"Nassim KAMAR",{"facility":229,"status":37,"city":230,"state":18,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":231,"geoPoint":235,"contacts":236},"Tours University Hospital","Tours",{"type":42,"coordinates":232},[233,234],0.70398,47.39484,{"lat":234,"lon":233},[237,239],{"name":238,"role":27,"phone":18,"phoneExt":18,"email":18},"Laure ELKRIEF",{"name":240,"role":27,"phone":18,"phoneExt":18,"email":18},"Helene BARRAUD",{"type":242,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100552429","addictological-intervention-in-liver-transplantation-recipients-100552429",false,"NCT06472973","ADDICTOlogical Intervention in LIVEr Transplantation Recipients","AddictoLIVE","Inclusion Criteria:\n\n* Aged 18 years or above\n* Hospitalized for LT for AALD as primary, secondary or tertiary indication\n* Discharged from intensive care unit to hepatology or surgery wards\n\nExclusion Criteria:\n\n* Severe alcohol-associated hepatitis as primary indication for liver transplantation\n* Impossibility of patient follow up over the next 2 years\n* General criteria:\n\n  * Refusal or absence of informed consent,\n  * Non-affiliation to the French national health insurance,\n  * Persons placed under legal protection, guardianship or curatorship","ALL","18 Years",{"count":253,"type":254},720,"ESTIMATED","INTERVENTIONAL",[257],"NA","Transplantation for end-stage-liver disease (ESLD) in the context of Alcohol-Associated Liver Disease (AALD) has been increasing and represents the main indication for Liver Transplantation (LT) in the world. Alcohol Use Disorder (AUD) is considered a brain chronic disease and requires a transdisciplinary approach that includes medical treatment and behavioral interventions.\n\nIn the context of LT, alcohol relapse occurs in 26 % up to 50% of LT recipients. Among Liver transplant recipients for AALD, severe alcoholic relapse (defined as more than 3 alcoholic drinks per day for women and 4\u002Fday for men) after LT leads to impaired longterm survival due to recurrent alcoholic cirrhosis (RAC), cardiovascular events and de novo cancer.\n\nSeveral strategies have been developed to prevent alcohol relapse. After LT, integrating an addiction team into the LT program has been advocated by the latest guidelines in Europe and the United States, in order to bring the management of alcohol-use disorder (AUD) in transplantation units, through the association of psychosocial and pharmacological interventions previously reported in AALD. However, those guidelines were based on descriptive studies, and the effect of this management needs to be confirmed through a randomized, controlled, multicenter study, involving centers that still do not include an addiction team in their LT programs.\n\nThis study will therefore assess prospectively and comparatively the impact of an addiction intervention after LT on return to alcohol use rates. We hypothesize that standardized targeted addiction monitoring of Liver Transplant recipients decreases the rates of alcohol relapse two years post-liver transplantation.",[260,261],"Alcohol Associated Liver Disease","Liver Transplantation",[263,264,265,266],"Liver transplantation","Addiction follow-up","Alcohol relapse","Survival","2026-06-17",{"date":269,"type":270},"2026-06-22","ACTUAL",{"date":272,"type":270},"2024-11-21",{"date":274,"type":254},"2030-11-21",{"name":5,"class":6},16]