[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626330":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":28,"locations":27,"responsibleParty":38,"collaborators":42,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":47,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":27,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":27,"overallStatus":65,"whyStopped":27,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":27},{"fullName":5,"class":6},"South Egypt Cancer Institute","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"(Control group):","SHAM_COMPARATOR","patients will receive the combined Pecto-Intercostal- Serratus anterior fascial planes Block with a total volume of 30 mL local anesthetic; 15 ml per block (13.5 ml Bupivacaine 0.25% + 1.5 ml normal saline for each block).",[13],"Procedure: combined Pecto-Intercostal- Serratus anterior fascial planes Block",{"label":15,"type":16,"description":17,"interventionNames":18},"(Magnesium group).:","ACTIVE_COMPARATOR","where patients will receive the combined Pecto-Intercostal- Serratus anterior fascial planes block with a total of 30 ml local anesthetic volume; 15 ml per block (13.5ml bupivacaine 0.25% + 1.5 ml MgSo4 10% (100 mg\u002Fml))",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","combined Pecto-Intercostal- Serratus anterior fascial planes Block","PIFB will be performed using a high-frequency linear ultrasound probe. probe should be inserted 2 cm laterally from the sternum and parallel to it. The Pecto-Intercostal Fascial plane is located between the pectoralis major muscle and the external intercostal muscle, or the costal cartilage. A 22 G 80 mm needle will be inserted under the pectoralis major and above the external intercostal muscle using the in-plane approach. Additionally, a test bolus of saline (2 mL) will be given.\n\nFor SAPB approach, patients will be positioned to the supine, and the injection sites are sterilized. The ipsilateral arm will be abducted at 90°. A high-frequency linear USG probe will be placed on the mid-axillary line in the axilla. Using an in-plane technique, a 100-mm block needle will be advanced caudo-cranially between the serratus anterior muscle and the fifth rib. After negative aspiration 1-2 mL of saline will be injected as a test dose.",[9,15],[26],"Ultrasound guided PIFB - SAPB approach",null,[29,35],{"name":30,"role":31,"phone":32,"phoneExt":33,"email":34},"mohamed fa abd elhamed, lecture","CONTACT","01015249890","02","m.farghaly.na@gmail.com",{"name":36,"role":31,"phone":37,"phoneExt":33,"email":27},"bahaa ga saad, lecturer","01003644592",{"type":39,"investigatorFullName":40,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"PRINCIPAL_INVESTIGATOR","Mohammed Farghaly Abd El hamid Ahmed","lecturer of anesthesia",[43],{"name":44,"class":6},"Assiut University","100626330","adding-magnesium-sulfate-to-combined-pecto-intercostal--serratus-anterior-planes-block-on-post-operative-analgesia-in-patients-undergoing-modified-radical-mastectomy-100626330",false,"NCT07434232","Adding Magnesium Sulfate to Combined Pecto-Intercostal & Serratus Anterior Planes Block on Post-operative Analgesia in Patients Undergoing Modified Radical Mastectomy","Efficacy of Adding Magnesium Sulfate to Combined Pecto-Intercostal & Serratus Anterior Planes Block on Post-operative Analgesia in Patients Undergoing Modified Radical Mastectomy: A Prospective, Randomized Controlled Clinical Trial","Mastectomy","Inclusion Criteria:\n\n* Female patients aged 30 to 75 years diagnosed with non-metastatic breast cancer and scheduled for modified radical mastectomy.\n* ASA, I-III and NYHA, I-II.\n* Written informed consent.\n\nExclusion Criteria:\n\n* ASA physical status \\>III and NYHA \\>II,\n* body mass index \\>40 kg\u002Fm2,\n* pregnant women,\n* Patients with organ failure or coagulation disorders.\n* Allergy to local anesthetics or magnesium sulfate\n* Contraindications as local infection\n* History of chronic pain or opioid use .\n* Unwilling to participate in the study","FEMALE","30 Years","75 Years",{"count":57,"type":58},100,"ESTIMATED","INTERVENTIONAL",[61],"NA","Here, in our study, we intend to compare the analgesic efficacy of magnesium sulfate as an adjuvant to local anesthetics added to the Pecto-Intercostal Fascial Block (PIFB) vs the Serratus Anterior Plane Block (SAPB) in patients undergoing modified radical mastectomy.\n\nStudy Endpoints Primary Endpoints: Total intravenous opioid consumption during the first 24 hours following surgery. Secondary Endpoints: Postoperative analgesia, 24 hours after surgery, assessed using the Visual Analog Scale (VAS) and time to first analgesic request.",[64],"Modified Radical Mastectomy","NOT_YET_RECRUITING","2026-02-22",{"date":68,"type":69},"2026-02-25","ACTUAL",{"date":71,"type":58},"2026-02-15",{"date":73,"type":58},"2027-04-15",{"name":5,"class":6}]