[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626648":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":40,"centralContacts":41,"locations":40,"responsibleParty":51,"collaborators":55,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":40,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":40,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":40,"overallStatus":77,"whyStopped":40,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":40},{"fullName":5,"class":6},"South Egypt Cancer Institute","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Group M (Magnesium Group)","ACTIVE_COMPARATOR","Patients will receive the combined PIP and ESP blocks using bupivacaine + magnesium sulphate.\n\n* 20 mL of 0.25% bupivacaine + 150 mg magnesium sulphate diluted to5 ml (in each block).\n* 150 mg with each block (total magnesium dose = 300 mg).",[13,14,15],"Procedure: Pectointercostal Plane Block (PIPB)","Procedure: Erector Spinae Plane Block (ESPB)","Drug: Magnesium sulfate",{"label":17,"type":18,"description":19,"interventionNames":20},"Group C (Control Group)","SHAM_COMPARATOR","Patients will receive the combined PIP and ESP blocks using bupivacaine only (20 ml of 0.25% bupivacaine)",[13,14],[22,29,35],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"PROCEDURE","Pectointercostal Plane Block (PIPB)","A high-frequency linear ultrasound probe will be placed at the level of the 2nd-3rd rib, medial to the pectoralis major muscle. The pectointercostal fascial plane located between the pectoralis major muscle and the external\u002Finternal intercostal muscles will be identified. Under in plane ultrasound guidance, the needle will be advanced into this plane, and the study drug will be administered. All patients will receive 20 mL of 0.25% bupivacaine; however, patients in Group M will additionally receive magnesium sulphate 150 mg diluted to 5 mL, which will be injected into the same plane.",[17,9],[28],"(PIPB)",{"type":23,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Erector Spinae Plane Block (ESPB)","For this block, the patient will be positioned laterally. The ultrasound probe will be placed at the T3-T5 vertebral level to visualize the transverse process. An in- plane technique will be used to advance the needle into the deep fascial plane beneath the erector spinae muscle. Once the correct position is confirmed, 20 mL of 0.25% bupivacaine will be injected, with Group M patients receiving an additional 150 mg of magnesium sulphate diluted to 5 mL. The total magnesium dose administered in Group M will be 300 mg. Negative aspiration will be performed prior to each injection to avoid intravascular administration.",[17,9],[34],"(ESPB):",{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":40},"DRUG","Magnesium sulfate","All patients will receive 20 mL of 0.25% bupivacaine; however, patients in Group M will additionally receive magnesium sulphate 150 mg diluted to 5 mL, which will be injected into the same plane. The total magnesium dose administered in Group M will be 300 mg",[9],null,[42,48],{"name":43,"role":44,"phone":45,"phoneExt":46,"email":47},"mohamed fa abd elhamed, lecturer","CONTACT","01015249890","02","m.farghaly.na@gmail.com",{"name":49,"role":44,"phone":50,"phoneExt":40,"email":40},"bahaa ga saad, lecturer","01003644592",{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":40,"oldOrganization":40},"PRINCIPAL_INVESTIGATOR","Mohammed Farghaly Abd El hamid Ahmed","lecturer of anesthesia",[56],{"name":57,"class":6},"Assiut University","100626648","adding-magnesium-sulphate-to-combined-pectointercostal-plane-and-erector-spinae-plane-blocks-for-acute-and-chronic-post-mastectomy-pain-100626648",false,"NCT07438366","Adding Magnesium Sulphate to Combined Pectointercostal Plane and Erector Spinae Plane Blocks for Acute and Chronic Post-Mastectomy Pain","Efficacy of Adding Magnesium Sulphate to Combined Pectointercostal Plane Block and Erector Spinae Plane Block for Acute and Chronic Post-Mastectomy Pain After Modified Radical Mastectomy. A Controlled Clinical Trial","Inclusion Criteria:\n\n* Female patients aged ≥18 years.\n* American Society of Anesthesiologists (ASA) class I-III.\n* Scheduled for unilateral modified radical mastectomy.\n\nExclusion Criteria:\n\n* Known allergy to local anesthetics or magnesium.\n* Coagulopathy or anticoagulant therapy.\n* Local infection at injection site.\n* Body mass index (BMI) ≥ 40 kg\u002Fm2.\n* Chronic opioid use or chronic pain disorders.\n* Neurological or psychiatric disorders affect pain perception.\n* Severe hepatic or renal impairment.\n* Pregnancy.\n* Lactation.","FEMALE","18 Years","65 Years",{"count":69,"type":70},60,"ESTIMATED","INTERVENTIONAL",[73],"NA","Given the burden of chronic postmastectomy pain and the need for effective, opioid-sparing analgesia, the propose of the randomized controlled trial is to evaluate the safety and efficacy of adding magnesium sulphate to the combination of PIP block and ESPB in patients undergoing modified radical mastectomy for reducing acute and chronic post mastectomy pain",[76],"Post-mastectomy Pain Syndrome","NOT_YET_RECRUITING","2026-02-22",{"date":80,"type":81},"2026-02-27","ACTUAL",{"date":83,"type":70},"2026-02-15",{"date":85,"type":70},"2027-02-15",{"name":5,"class":6}]