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surgery.\n* Patients received medical therapy, open surgical, endovascular, or hybrid repair.\n* Any other major cardiac surgical procedure concomitant with surgery for AAS, such as coronary artery bypass grafting or carotid artery replacement;\n* The patient or guardian agrees to participate in this study. Exclusion criteria\n* Patients aged \\\u003C 18 years.\n* Onset of symptoms \\> 14 days from surgery.\n* AAS secondary to traumatic or iatrogenic injury.\n* Patients who declined participation in registration and follow-up investigation.","ALL","18 Years",{"count":468,"type":469},10000,"ESTIMATED","OBSERVATIONAL","Acute aortic syndrome (AAS) is a life-threatening condition. Inflammation plays a key role in the pathogenesis, development and progression of AAS, and is associated with significant mortality and morbidity. Understanding the inflammatory responses and inflammation resolutions is essential for an appropriate management of AAS.\n\nTwenty Chinese cardiovascular centers have collaborated to create a multicenter observational registry (named Chinese registry of Additive Anti-inflammatory Action for Aortopathy \\& Arteriopathy \\[5A\\]), with consecutive enrollment of adult patients who underwent surgery for AAS that was started on Jan 1, 2016 and will be ended on December 31, 2040. Specially, the impact of inflammation and anti-inflammatory strategies on the early and late adverse events are investigated. Primary outcomes are severe systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), Sequential Organ Failure Assessment (SOFA) scores at 7 days following this current surgery. Secondary outcomes are SISR, 30-day mortality, operative mortality, hospital mortality, new-onset stroke, acute kidney injury, surgical site infection, reoperation for bleeding, blood transfusion and length of stay in the intensive care unit.",[473],"Acute Aortic Syndrome",[473],"2026-02-05",{"date":477,"type":478},"2026-02-09","ACTUAL",{"date":480,"type":478},"2016-01-01",{"date":482,"type":469},"2030-12-31",{"name":5,"class":6},34]