[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643699":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":33,"locations":32,"responsibleParty":42,"collaborators":32,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":48,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":32,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":32,"overallStatus":68,"whyStopped":32,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":32},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"CAD\u002FCAM Milled Endocrown","ACTIVE_COMPARATOR","Endocrown restoration fabricated by subtractive CAD\u002FCAM milling from HC Hard Block hybrid nano-ceramic (Shofu Inc., Japan), designed using ExoCAD software and milled on a five-axis wet-milling unit. Adhesively cemented using Beautilink SA self-adhesive dual-cure resin cement (Shofu Inc., Japan).",[13],"Device: CAD\u002FCAM Milled HC Hard Block Endocrown",{"label":15,"type":16,"description":17,"interventionNames":18},"3D-Printed Endocrown","EXPERIMENTAL","Endocrown restoration fabricated by additive manufacturing using VarseoSmile TriniQ ceramic-filled photopolymer resin (BEGO GmbH \\& Co. KG, Germany), printed on a 4K LCD printer at 30-45 degree build angle, post-cured under nitrogen atmosphere. Adhesively cemented using Beautilink SA self-adhesive dual-cure resin cement (Shofu Inc., Japan).",[19],"Device: 3D-Printed VarseoSmile TriniQ Endocrown",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","CAD\u002FCAM Milled HC Hard Block Endocrown","Endocrown restoration milled from HC Hard Block hybrid nano-ceramic (Shofu Inc., Japan) using a five-axis wet-milling CAD\u002FCAM unit. Restoration designed with ExoCAD software, finished and glazed per manufacturer protocol, and cemented with Beautilink SA self-adhesive dual-cure resin cement (Shofu Inc., Japan).",[9],[9],{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"3D-Printed VarseoSmile TriniQ Endocrown","Endocrown restoration 3D-printed using VarseoSmile TriniQ ceramic-filled photopolymer resin (BEGO GmbH \\& Co. KG, Germany) on a 4K LCD printer at 30-45 degree build angle. Post-cured under nitrogen atmosphere, surface glazed, and cemented with Beautilink SA self-adhesive dual-cure resin cement (Shofu Inc., Japan).",[15],[15],null,[34,39],{"name":35,"role":36,"phone":37,"phoneExt":32,"email":38},"Dina Ez Mohamed, BDS MSc PhD","CONTACT","01008007157","dina.ezz@dentistry.cu.edu.eg",{"name":40,"role":36,"phone":32,"phoneExt":32,"email":41},"Rawda H Abdelaziz, BDS MSc PhD","rawda.hesham@dentistry.cu.edu.eg",{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Dina Ezz","Associate Professor of Conservative Dentistry","100643699","additive-vs-subtractive-manufacturing-for-endocrown-fabrication-a-24-month-rct-100643699",false,"NCT07633574","Additive vs Subtractive Manufacturing for Endocrown Fabrication: A 24-Month RCT","Additive Versus Subtractive Manufacturing for Endocrown Fabrication: A Clinical Comparison of 3D-Printed Ceramic-Filled Photopolymer Resin and CAD\u002FCAM Milled Resin Nano-Ceramics Endocrowns in Posterior Teeth - A 24-Month Randomized Controlled Trial","ENDO-3D","Inclusion Criteria:\n\n* Age 25-45 years, male or female\n* Endodontically treated molar tooth with radiographically confirmed treatment success and no clinical signs of failure\n* Sufficient remaining coronal structure for endocrown preparation: minimum three walls, wall thickness 1.5 mm or greater, pulp chamber depth 3 mm or greater, supragingival preparation margins\n* Completely erupted tooth with intact periodontal support\n* Minimum of 20 occluding teeth\n* Satisfactory oral hygiene status\n* Capable of providing written informed consent and committed to scheduled follow-up visits\n\nExclusion Criteria:\n\n* Diagnosed parafunctional habit or nocturnal bruxism\n* Uncontrolled systemic illness or physical disability precluding safe participation\n* Heavy tobacco use\n* Current or suspected pregnancy\n* Periapical disease or radiographic signs of endodontic failure\n* Evidence of pathological tooth wear or occlusal erosion\n* Moderate-to-severe periodontitis or tooth with hopeless prognosis\n* Radiographic or clinical evidence of vertical root fracture\n* Impaired decision-making capacity or anticipated non-compliance","ALL","25 Years","45 Years",{"count":58,"type":59},60,"ESTIMATED","INTERVENTIONAL",[62],"NA","This randomized controlled trial (RCT) compares the 24-month clinical performance of endocrown restorations fabricated by two digital manufacturing pathways: additive manufacturing using 3D-printed ceramic-filled photopolymer resin (VarseoSmile TriniQ, BEGO) versus subtractive computer-aided design\u002Fcomputer-aided manufacturing (CAD\u002FCAM) milling from hybrid nano-ceramic blocks (HC Hard Block, Shofu). Sixty endocrowns will be placed in endodontically treated posterior molars and evaluated using modified United States Public Health Service (USPHS) criteria at 6, 12, and 24 months. The trial is conducted at the Conservative Dentistry Department, Faculty of Dentistry, Cairo University.",[65,66,67],"Tooth, Nonvital","Dental Restoration","Endodontically Treated Teeth","NOT_YET_RECRUITING","2026-06-04",{"date":71,"type":72},"2026-06-08","ACTUAL",{"date":74,"type":59},"2026-06",{"date":76,"type":59},"2028-09",{"name":5,"class":6}]