[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613952":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":7,"responsibleParty":14,"collaborators":7,"id":19,"slug":20,"hasResults":21,"nctId":22,"briefTitle":23,"officialTitle":24,"acronym":25,"eligibilityCriteria":26,"healthyVolunteers":27,"sex":28,"minAge":29,"maxAge":30,"enrollmentInfo":31,"targetDuration":7,"studyType":34,"phases":7,"briefSummary":35,"conditions":36,"keywords":40,"overallStatus":44,"whyStopped":7,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":7},{"fullName":5,"class":6},"Kaohsiung Medical University","OTHER",null,[9],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Tzu Yu Pan, PhD","CONTACT","886-3221806","R990174@gap.kmu.edu.tw",{"type":15,"investigatorFullName":16,"investigatorTitle":17,"investigatorAffiliation":18,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Tzu Yu Pan","Postdoctoral Researcher","Kaohsiung Medical University Chung-Ho Memorial Hospital","100613952","adh1b-and-aldh-gene-variants-and-lung-cancer-risk-100613952",false,"NCT07273279","ADH1B and ALDH Gene Variants and Lung Cancer Risk","Associations of ADH1B and ALDH Family Gene Polymorphisms With Lung Cancer Risk and Its Subtypes: Results From the Oncoarray Project of the International Lung Cancer Consortium","ALDH","Inclusion Criteria:\n\n* Incident lung cancer cases confirmed by pathology and healthy adult over age of 18 years.\n\nExclusion Criteria:\n\n* Individuals with incomplete data will not be included as study participants.",true,"ALL","18 Years","99 Years",{"count":32,"type":33},100000,"ESTIMATED","OBSERVATIONAL","Lung cancer in never-smokers is increasingly recognized as a disease influenced by genetic susceptibility. Aldehyde-metabolizing enzymes, including the ALDH gene family and ADH1B, play key roles in detoxifying reactive aldehydes that can damage DNA and promote oxidative stress. In this study, we will examine whether ten selected genetic variants, nine single nucleotide polymorphisms (SNPs) across five ALDH family genes and one variant in ADH1B are associated with the risk of lung cancer and its major subtypes. Limited epidemiological evidence is currently available on the association between these aldehyde-metabolizing gene variants and lung cancer. This research aims to clarify their potential contribution to the development of lung cancer, particularly among never-smokers.",[37,38,39],"Condition\u002FDisease","Lung Cancer (Diagnosis)","Lung Adenocarcinoma",[41,42,43],"ALDH2","ADH1B","Lung cancer","NOT_YET_RECRUITING","2025-11-26",{"date":47,"type":48},"2025-12-09","ACTUAL",{"date":50,"type":33},"2026-01",{"date":52,"type":33},"2027-12",{"name":5,"class":6}]