[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633127":3},{"organization":4,"armGroups":7,"interventions":68,"overallOfficials":67,"centralContacts":94,"locations":103,"responsibleParty":122,"collaborators":67,"id":124,"slug":125,"hasResults":126,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":126,"sex":132,"minAge":133,"maxAge":67,"enrollmentInfo":134,"targetDuration":67,"studyType":137,"phases":138,"briefSummary":140,"conditions":141,"keywords":144,"overallStatus":151,"whyStopped":67,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":161},{"fullName":5,"class":6},"Kaiser Permanente","OTHER",[8,15,20,25,29,34,38,42,46,51,55,59,63],{"label":9,"type":10,"description":11,"interventionNames":12},"SMS\u002FSMS","EXPERIMENTAL","Participants in this arm will receive an initial SMS (text message) encouraging statin refill. Participants who do not refill their prescription within 14 days will receive a second SMS.",[13,14],"Behavioral: SMS (Initial Outreach)","Behavioral: SMS (Follow-up for Non-responders)",{"label":16,"type":10,"description":17,"interventionNames":18},"SMS\u002FSecure Portal Message","Participants in this arm will receive an initial SMS (text message) encouraging statin refill. Participants who do not refill their prescription within 14 days will receive a secure portal message.",[13,19],"Behavioral: Secure Portal Message (Follow-up for Non-responders)",{"label":21,"type":10,"description":22,"interventionNames":23},"SMS\u002FNon-secure Email","Participants in this arm will receive an initial SMS (text message) encouraging statin refill. Participants who do not refill their prescription within 14 days will receive a non-secure email.",[13,24],"Behavioral: Non-secure Email (Follow-up for Non-responders)",{"label":26,"type":10,"description":27,"interventionNames":28},"SMS\u002FUsual Care","Participants in this arm will receive an initial SMS (text message) encouraging statin refill. Participants who do not refill their prescription within 14 days will receive no additional outreach (usual care).",[13],{"label":30,"type":10,"description":31,"interventionNames":32},"Secure Portal Message\u002FSecure Portal Message","Participants in this arm will receive an initial secure portal message encouraging statin refill. Participants who do not refill their prescription within 14 days will receive a second secure portal message.",[33,19],"Behavioral: Secure Portal Message (Initial Outreach)",{"label":35,"type":10,"description":36,"interventionNames":37},"Secure Portal Message\u002FSMS","Participants in this arm will receive an initial secure portal message encouraging statin refill. Participants who do not refill their prescription within 14 days will receive an SMS (text message).",[33,14],{"label":39,"type":10,"description":40,"interventionNames":41},"Secure Portal Message\u002FNon-secure Email","Participants in this arm will receive an initial secure portal message encouraging statin refill. Participants who do not refill their prescription within 14 days will receive a non-secure email.",[33,24],{"label":43,"type":10,"description":44,"interventionNames":45},"Secure Portal Message\u002FUsual Care","Participants in this arm will receive an initial secure portal message encouraging statin refill. Participants who do not refill their prescription within 14 days will receive no additional outreach (usual care).",[33],{"label":47,"type":10,"description":48,"interventionNames":49},"Non-secure Email\u002FNon-secure Email","Participants in this arm will receive an initial non-secure email encouraging statin refill. Participants who do not refill their prescription within 14 days will receive a second non-secure email.",[50,24],"Behavioral: Non-secure Email (Initial Outreach)",{"label":52,"type":10,"description":53,"interventionNames":54},"Non-secure Email\u002FSMS","Participants in this arm will receive an initial non-secure email encouraging statin refill. Participants who do not refill their prescription within 14 days will receive an SMS (text message).",[50,14],{"label":56,"type":10,"description":57,"interventionNames":58},"Non-secure Email\u002FSecure Portal Message","Participants in this arm will receive an initial non-secure email encouraging statin refill. Participants who do not refill their prescription within 14 days will receive a secure portal message.",[50,19],{"label":60,"type":10,"description":61,"interventionNames":62},"Non-secure Email\u002FUsual Care","Participants in this arm will receive an initial non-secure email encouraging statin refill. Participants who do not refill their prescription within 14 days will receive no additional outreach (usual care).",[50],{"label":64,"type":65,"description":66,"interventionNames":67},"Usual Care\u002FUsual Care","NO_INTERVENTION","Participants in this arm will receive usual care with no proactive outreach during the study period.",null,[69,74,78,82,86,90],{"type":70,"name":71,"description":72,"armGroupLabels":73,"otherNames":67},"BEHAVIORAL","SMS (Initial Outreach)","Participants will receive an initial SMS (text message) encouraging statin refill. Messages may include reminder prompts and interactive features implemented through automated keyword-triggered responses that provide refill instructions or educational information.",[21,9,16,26],{"type":70,"name":75,"description":76,"armGroupLabels":77,"otherNames":67},"Secure Portal Message (Initial Outreach)","Participants will receive an initial secure message through the kp.org patient portal encouraging statin refill. Messages are delivered within the secure portal environment and may include informational and reminder content.",[39,35,30,43],{"type":70,"name":79,"description":80,"armGroupLabels":81,"otherNames":67},"Non-secure Email (Initial Outreach)","Participants will receive an initial non-secure email encouraging statin refill. Emails may include informational content and reminders but are delivered outside of the secure patient portal.",[47,52,56,60],{"type":70,"name":83,"description":84,"armGroupLabels":85,"otherNames":67},"SMS (Follow-up for Non-responders)","Participants who do not refill their prescription within 14 days of the initial outreach will receive a follow-up SMS (text message) encouraging statin refill. Messages may include reminder prompts and interactive features implemented through automated keyword-triggered responses that provide refill instructions or educational information.",[52,9,35],{"type":70,"name":87,"description":88,"armGroupLabels":89,"otherNames":67},"Secure Portal Message (Follow-up for Non-responders)","Participants who do not refill their prescription within 14 days of the initial outreach will receive a follow-up secure portal message through the kp.org patient portal encouraging statin refill. Messages are delivered within the secure portal environment and may include informational and reminder content.",[56,16,30],{"type":70,"name":91,"description":92,"armGroupLabels":93,"otherNames":67},"Non-secure Email (Follow-up for Non-responders)","Participants who do not refill their prescription within 14 days of the initial outreach will receive a follow-up non-secure email encouraging statin refill. Emails may include informational content and reminders but are delivered outside of the secure patient portal.",[47,21,39],[95,100],{"name":96,"role":97,"phone":98,"phoneExt":67,"email":99},"Ankeet S Bhatt, MD, MBA, ScM","CONTACT","415-407-1754","Ankeet.S.Bhatt@kp.org",{"name":101,"role":97,"phone":98,"phoneExt":67,"email":102},"Mirasol M Apostol-Largeteau, MPH","Mirasol.M.Apostol-Largeteau@kp.org",[104],{"facility":105,"status":67,"city":106,"state":107,"zip":108,"country":109,"countryCode":110,"cosmosGeoPoint":111,"geoPoint":116,"contacts":117},"Kaiser Permenante Northern California","Pleasant Hill","California","94588","United States","US",{"type":112,"coordinates":113},"Point",[114,115],-122.0608,37.94798,{"lat":115,"lon":114},[118],{"name":119,"role":97,"phone":120,"phoneExt":67,"email":121},"Ankeet Bhatt, MD, MBA, ScM","4154706571","ankeet.s.bhatt@kp.org",{"type":123,"investigatorFullName":67,"investigatorTitle":67,"investigatorAffiliation":67,"oldNameTitle":67,"oldOrganization":67},"SPONSOR","100633127","adherence-to-dyslipidemia-therapy-harnessing-evidence-from-randomized-evaluations-in-atherosclerotic-cardiovascular-disease-100633127",false,"NCT07522645","Adherence to Dyslipidemia Therapy: Harnessing Evidence From Randomized Evaluations in AtheroSclerotic CardioVascular Disease","Adherence to Dyslipidemia Therapy: Harnessing Evidence From Randomized Evaluations in AtheroSclerotic CardioVascular Disease (ADHERE-ASCVD)","ADHERE-ASCVD","Inclusion Criteria\n\n1. Age ≥18 years\n2. Active Kaiser Permanente Northern California (KPNC) membership\n3. Diagnosis of atherosclerotic cardiovascular disease (ASCVD) or diabetes and inclusion in the Preventing Heart Attacks and Strokes Everyday (PHASE) Registry\n4. No statin prescription fill within the prior 3 months\n5. Statin adherence \\\u003C80% in the prior 12 months\n6. Active kp.org account within the past 12 months\n7. Valid email address and text-capable phone number on file\n\nExclusion Criteria\n\n1. Documented allergic reaction or contraindication to statin therapy\n2. Receiving hospice care\n3. Medicare beneficiaries\n4. Other exclusions applied per operational standard practice","ALL","18 Years",{"count":135,"type":136},22000,"ESTIMATED","INTERVENTIONAL",[139],"NA","The goal of the ADHERE-ASCVD study is to evaluate and optimize patient-facing messaging strategies to improve statin refill and adherence among adults with atherosclerotic cardiovascular disease (ASCVD) or diabetes.\n\nThe main questions it aims to answer are:\n\n1. Do different outreach methods (such as text messages, secure portal messages, or email) increase short-term statin refill compared to usual care?\n2. Among patients who do not initially refill their prescription, does changing the outreach method improve refill rates?\n\nThe team with operational partners will evaluate the comparitive effectivessness of multiple messaging strategies delivered through existing health system communication channels, including SMS (text messaging), secure patient portal messages, non-secure email, and usual care (no additional outreach).\n\nParticipants\n\n* Receive an initial outreach message encouraging statin refill (or usual care) Be monitored for statin refill within 14 days\n* Potentially receive a second outreach message using the same or a different communication method if they do not initially refill their prescription\n* Have their medication refill patterns tracked over time, including longer-term adherence outcomes",[142,143],"ASCVD","Diabetes",[142,145,146,147,148,149,150],"ASCVD management","statin therapy","statin","SMART design","messaging strategies","patient outreach","NOT_YET_RECRUITING","2026-04-13",{"date":154,"type":155},"2026-04-15","ACTUAL",{"date":157,"type":136},"2026-04-14",{"date":159,"type":136},"2028-12-31",{"name":5,"class":6},1]