[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100511051":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":38,"locations":45,"responsibleParty":64,"collaborators":67,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":26,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Université de Sherbrooke","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group","ACTIVE_COMPARATOR","without T2D according to Diabetes Canada diagnostics criteria:",[13,14],"Procedure: Bariatric surgery","Drug: Nicotinic Acid",{"label":16,"type":17,"description":18,"interventionNames":19},"group with Type 2 diabetes","EXPERIMENTAL","with T2D according to Diabetes Canada diagnostics criteria:",[13,14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Bariatric surgery","Laparoscopic Sleeve Gastrectomy",[9,16],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DRUG","Nicotinic Acid","Only during A1. 150mg every half hour for 6 hours. A total dose of 1800mg will be ingested.",[9,16],[33],"Niacin",[35],{"name":36,"affiliation":5,"role":37},"André Carpentier, MD","PRINCIPAL_INVESTIGATOR",[39],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Frédérique Frisch","CONTACT","1-819-346-1110","12394","frederique.frisch@usherbrooke.ca",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"centre de recherche du CHUS","RECRUITING","Sherbrooke","Quebec","J1H 5N4","Canada","CA",{"type":55,"coordinates":56},"Point",[57,58],-71.89908,45.40008,{"lat":58,"lon":57},[61],{"name":62,"role":41,"phone":63,"phoneExt":26,"email":44},"Frederique Frisch","8193461110",{"type":37,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"André Carpentier","Tenure professor",[68,70],{"name":69,"class":6},"Institut universitaire de cardiologie et de pneumologie de Québec, University Laval",{"name":71,"class":6},"Centre de recherche du Centre hospitalier universitaire de Sherbrooke","100511051","adipose-tissue-storage-in-the-rapid-remission-of-hepatic-and-cardiac-metabolic-dysfunction-after-bariatric-surgery-100511051",false,"NCT05934409","Adipose Tissue Storage in the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery","Improved Adipose Tissue Storage of Dietary Fatty Acids as a New Mechanism for the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery","CB5","Inclusion Criteria:\n\n* Aged 18 to 65\n* BMI 35 kg\u002Fm2\n* Diagnosed T2D - according to Diabetes Canada diagnostics criteria.\n* Diagnosed non-T2D - according to Diabetes Canada diagnostics criteria.\n* Women with a negative serum pregnancy test.\n\nExclusion Criteria:\n\n* Treatment with an oral contraceptive;\n* Treatment with fibrate, thiazolidinedione, insulin, or beta-blocker, drugs that affect metabolism and cannot be stopped temporarily or which have long-lasting effects;\n* Presence of overt cardiovascular disease, liver or renal failure or other uncontrolled medical conditions;\n* Any other contraindication to surgery or to temporarily suspending current medications for diabetes, lipids or hypertension;\n* Smoking or consumption of more than 2 alcoholic beverages per day;\n* Any contraindication to MRI;\n* A Diabetes Remission (DiaRem) score \\>8 (low probability of T2D remission);\n* Having participated to a research study with exposure to radiation in the last two years before the start of the study;\n* Pregnant or breastfeeding women;\n* Patients weighing more than 200 kg to respect the weight and gantry limit of our MRI and PET\u002FCT scanners.\n* Being allergic to eggs",true,"ALL","18 Years","65 Years",{"count":85,"type":86},40,"ESTIMATED","INTERVENTIONAL",[89],"NA","The present protocol aims to understand and establish whether there is a causal link between adipose tissue metabolic remodeling and Type 2 Diabetes (T2D) remission after bariatric surgery.\n\nAll participants will have a bariatric surgery, divided in 2 groups: with or without T2D.",[92],"Diabetes Mellitus Type 2",[23,94,95,96],"remission from Type 2 diabetes","PET imaging","adipose tissue","2026-02-09",{"date":99,"type":100},"2026-02-10","ACTUAL",{"date":102,"type":100},"2023-11-01",{"date":104,"type":86},"2028-05-01",{"name":5,"class":6},1]