[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636944":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":26,"centralContacts":35,"locations":41,"responsibleParty":54,"collaborators":26,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":26,"enrollmentInfo":66,"targetDuration":26,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":26,"overallStatus":77,"whyStopped":26,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Florida Institute for Human and Machine Cognition","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Nitrate Group","EXPERIMENTAL","Participants will be randomized to an intervention in which they take 800 mg (2 x 400 mg) nitrate-enriched beetroot juice drink \\[Beet It Sport Nitrate 400 (70 ml per drink)\\]. Both nitrate and placebo will be purchased from Beet It.",[13,14],"Dietary Supplement: Nitrate enriched beetroot juice","Other: 12 week of combined exercise training",{"label":16,"type":17,"description":18,"interventionNames":19},"Placebo Group","PLACEBO_COMPARATOR","Participants will be randomized to an intervention in which they take 800 mg (2 x 400 mg) nitrate-deprived, manufacturer-matched beetroot juice drink \\[Beet It Sport Nitrate 400 (70 ml per drink)\\]. Both nitrate and placebo will be purchased from Beet It.",[20,14],"Dietary Supplement: Nitrate depleted beetroot juice",[22,27,31],{"type":23,"name":24,"description":11,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Nitrate enriched beetroot juice",[9],null,{"type":23,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Nitrate depleted beetroot juice","Manufacturer-matched placebo that is nitrate-depleted beetroot juice (70 ml per drink). Both nitrate and placebo will be purchased from Beet It.",[16],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":26},"12 week of combined exercise training","All participants: An exercise dose will be composed of 12 wk of 3d\u002Fwk laboratory based supervised prescribed with strategic variations in intensity, volume, and modality across the 3 weekly sessions. During Monday and Friday RT sessions, participants complete 3 sets x 8-12 reps to volitional fatigue for leg press, knee extension, leg curl, overhead press, lat pulldown or row, and chest press in superset fashion with a 60 s rest between supersets. On Wednesday, participants perform 2 sets of 13-15 reps of leg press, knee extension, chest press and lat pulldowns with specific cues for speed and fast contractions. RT is complemented by the ET component which follows a Moderate-High Moderate intensity schedule with 30 min of 70-75% HRR steady state cycling on Monday and Friday separated by a Wednesday 20 min high intensity interval session on a cycle ergometer (1 min on\u002Foff; 10 cycles) at near maximal intensity with a target of 90% HRR.",[9,16],[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Craig Tuggle, MA","CONTACT","850-202-4416","ctuggle@ihmc.org",[42],{"facility":5,"status":26,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":26},"Pensacola","Florida","32502","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-87.21691,30.42131,{"lat":52,"lon":51},{"type":55,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100636944","adjuvant-nitrate-to-boost-exercise-induced-health-benefits-in-older-adults-100636944",false,"NCT07572266","Adjuvant Nitrate to Boost Exercise-induced Health Benefits in Older Adults","BOOST-X","Inclusion Criteria:\n\n1. Male or female aged 60 years or older\n2. Free of chronic disease or disorder that would preclude full participation or have the potential to confound results\n3. No structured exercise program (2 or more bouts\u002Fwk) within previous 12 months\n4. Cognitively capable of providing informed consent\n\nExclusion Criteria:\n\n1. BMI ≥ 30.0 kg\u002Fm2\n2. Neurodegenerative disease\n3. Neuromuscular, musculoskeletal or orthopedic disorder or condition that would limit ability to perform the exercise prescription and\u002For physical performance testing\n4. Diagnosed orthostatic hypotension, i.e., a drop in systolic blood pressure of at least 20 mmHg or a drop in diastolic blood pressure of at least 10 mmHg within three minutes of standing up from a sitting or lying position.\n5. Resting blood pressure \\\u003C90\u002F60 mmHg or \\>160\u002F95 mmHg\n6. Uncontrolled hypertension\n7. Any current cardiovascular disease or cardiopulmonary instability\n8. Recent cardiovascular event or procedure within the preceding 6 months\n\n   1. If valve replacement has been performed, patient may not be enrolled for 12 months after the procedure\n   2. Any mechanical valve replacement that requires continuous warfarin anti-coagulation\n9. Anemia: Hgb \\\u003C11.0 (♂),10.0 (♂) gm\u002Fdl\n10. Diabetes with HgbA1c \\>7.0% or fasting blood glucose ≥ 130 mg\u002Fdl\n11. Liver disease with ALT \\> 52 U\u002Fl)\n12. Chronic kidney disease (eGFR \\\u003C 45)\n13. Any current infectious disease\n14. Any other disease or disorder that could influence exercise response, preclude full participation or have the potential to confound results (e.g., chronic lung disease, cognitive impairment, current cancer diagnosis or within 2 yr remission, cerebrovascular disease, pain)\n15. Life expectancy \\\u003C 1 year Medications \u002F lifestyle\n16. Insulin sensitizing\u002Fblood glucose lowering agents such as metformin\n17. Currently on or have used GLP-1 agonist or other metabolic \u002F weight loss drug in previous 12 weeks\n18. Use of nitrate medications\n19. High dose statin (≥40 mg\u002Fd simvastatin equivalence)\n20. Chronic corticosteroids\n21. Testosterone or other anabolic\u002Fandrogenic hormone therapy\n22. Lidocaine allergy\n23. Regular tobacco use and\u002For vaping \\> 1\u002Fwk\n24. Use of cannabis \\> 1\u002Fwk\n25. Excessive alcohol consumption (3 drinks\u002Fd or 7 drinks\u002Fwk for females; 4 drinks\u002Fd or 14 drinks\u002Fwk for males)\n26. Use of illicit drugs (e.g., cocaine, opioids)\n27. Unable to commit to \\~4 months required to complete the study",true,"ALL","60 Years",{"count":67,"type":68},226,"ESTIMATED","INTERVENTIONAL",[71],"NA","Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments to compromise intrinsic capacity and healthspan. Exercise is the only multipotent treatment with promise to mitigate many of the aging hallmarks, but there is substantial variability in individual exercise responsiveness. Thus, the investigators approach to boosting exercise responsiveness in aging is to combine an exercise training prescription containing both endurance and resistance training (in alignment with DHHS guidelines) with a nitrate-enriched dietary supplement to augment the cellular, tissue, and systemic adaptations that induce myriad health benefits of exercise in older adults.",[74,75,76],"Aging","Aging Well","Healthy Aging","NOT_YET_RECRUITING","2026-04-30",{"date":80,"type":81},"2026-05-07","ACTUAL",{"date":83,"type":68},"2026-05",{"date":85,"type":68},"2031-05",{"name":5,"class":6},1]