[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100563275":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":31,"centralContacts":44,"locations":50,"responsibleParty":75,"collaborators":78,"id":89,"slug":90,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":97,"sex":98,"minAge":99,"maxAge":100,"enrollmentInfo":101,"targetDuration":12,"studyType":104,"phases":105,"briefSummary":107,"conditions":108,"keywords":12,"overallStatus":52,"whyStopped":12,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"National University of Singapore","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard care","NO_INTERVENTION","Receive usual standard of care for lipid management",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Standard care + Human Coach-supported Digital\u002FAI Personal Health Assistant","EXPERIMENTAL","The intervention group will receive personalised feedback through the digital mobile health app coupled with human coaching (i.e., support from a human coach-supported digital\u002FAI personal health assistant) on top of usual clinical care for cholesterol management.",[18],"Behavioral: Human Coach-supported Digital\u002FAI Personal Health Assistant to Improve Adherence to Lipid-Lowering Medications",[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Human Coach-supported Digital\u002FAI Personal Health Assistant to Improve Adherence to Lipid-Lowering Medications","Receive personalised feedback and educational content curated by local clinicians and pharmacists through the CADENCE D-PHA app coupled with six sessions of human coaching on top of usual clinical care for lipid management over 6 months",[14],[26,27,28,29,30],"Artificial Intelligence","Health Coaching","CADENCE D-PHA","Improve Adherence to Lipid-Lowering Medications","Statin",[32,36,39,42],{"name":33,"affiliation":34,"role":35},"Ying Xian Chua","National University Polyclinics","PRINCIPAL_INVESTIGATOR",{"name":37,"affiliation":38,"role":35},"Ziliang Lim","National Healthcare Group Polyclinics",{"name":40,"affiliation":41,"role":35},"Andy Khong","Nanyang Technological University",{"name":43,"affiliation":41,"role":35},"Andy Hau Yan Ho",[45],{"name":46,"role":47,"phone":48,"phoneExt":12,"email":49},"Doreen Su-Yin Tan, Pharm.D.","CONTACT","66016471","doreen.tan.sy@nus.edu.sg",[51,66],{"facility":38,"status":52,"city":53,"state":12,"zip":54,"country":53,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"RECRUITING","Singapore","138543","SG",{"type":57,"coordinates":58},"Point",[59,60],103.85007,1.28967,{"lat":60,"lon":59},[63],{"name":64,"role":47,"phone":12,"phoneExt":12,"email":65},"TRO Admin","TRO@nhg.com.sg",{"facility":34,"status":52,"city":53,"state":12,"zip":67,"country":53,"countryCode":55,"cosmosGeoPoint":68,"geoPoint":70,"contacts":71},"609606",{"type":57,"coordinates":69},[59,60],{"lat":60,"lon":59},[72],{"name":73,"role":47,"phone":12,"phoneExt":12,"email":74},"NUHS Research Office","partnership@nuhs.edu.sg",{"type":35,"investigatorFullName":76,"investigatorTitle":77,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Tan Su-Yin Doreen","Associate Professor",[79,81,82,84,87],{"name":80,"class":6},"National University Polyclinics, Singapore",{"name":41,"class":6},{"name":38,"class":83},"OTHER_GOV",{"name":85,"class":86},"Consortium for Clinical Research and Innovation, Singapore (CRIS)","UNKNOWN",{"name":88,"class":6},"National University Heart Centre, Singapore","100563275","adlip-human-coach-supported-digitalai-personal-health-assistant-to-improve-adherence-to-lipid-lowering-medication-100563275",false,"NCT06614049","AdLip: Human Coach-supported Digital\u002FAI Personal Health Assistant to Improve Adherence to Lipid-Lowering Medication","AdLip: Use of Human Coach-supported Digital\u002FAI Personal Health Assistant to Improve Adherence to Lipid-Lowering Medications: a Multi-centre Randomised Controlled Trial","AdLip","Inclusion Criteria:\n\n* Between 21 to 84 years old\n* Prescribed statins with or without ezetimibe for hyperlipidaemia.\n* Medication non-adherence as defined by the \\"Extent to Non-adherence\\" sub-scale of the DOSE Non-Adherence Measure), with a score \\> 1 (range from 0-15)\n* Singapore residents (citizens, permanent residents, or long-term pass holders).\n* In possession of a smartphone or tablet with Android or iOS operating systems.\n* Have internet access on their mobile devices.\n\nExclusion Criteria:\n\n* Does not read or understand English. Current use of smartphone medication adherence app(s) that include statins.\n* Concurrent use of PCSK9 Inhibitors in addition to statins and\u002For ezetimibe\n* Participation in another study that uses medications that could affect lipid levels\n* Severe renal impairment defined as chronic kidney disease stage 4 and above.\n* Severe liver disease (Child-Pugh Class C)\n* Existing muscular-related complaints or diagnoses which may confound adverse event reporting\n* Uncorrected thyroid conditions, especially poorly-controlled hypothyroidism\n* Documented psychiatric diagnosis or history of mental illness or deemed as unable to give informed consent.\n* Currently pregnant, breastfeeding or expecting to get pregnant during the course of the study (1 year).\n* Guarded prognosis with expectant mortality within 12 months or less.",true,"ALL","21 Years","84 Years",{"count":102,"type":103},450,"ESTIMATED","INTERVENTIONAL",[106],"NA","Investigators hypothesize that the use of a human coach-supported digital\u002FAI personal health assistant (app) will improve adherence to cholesterol-lowering medications (statins with or without ezetimibe) among patients with hyperlipidaemia and suboptimal LDL-C control, when compared to standard care.",[109,110],"Hyperlipidemia","Medication Nonadherence","2024-10-01",{"date":113,"type":114},"2024-10-03","ACTUAL",{"date":116,"type":114},"2024-06-10",{"date":118,"type":103},"2026-02-14",{"name":5,"class":6},2]