[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100545332":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":41,"locations":51,"responsibleParty":129,"collaborators":131,"id":139,"slug":140,"hasResults":141,"nctId":142,"briefTitle":143,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":141,"sex":146,"minAge":147,"maxAge":148,"enrollmentInfo":149,"targetDuration":20,"studyType":152,"phases":153,"briefSummary":155,"conditions":156,"keywords":160,"overallStatus":54,"whyStopped":20,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":174},{"fullName":5,"class":6},"Istituto Ortopedico Rizzoli","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Pediatric patients with musculoskeletal diseases","EXPERIMENTAL","Children, adolescents, and young adults suffering from musculoskeletal disorders (MMD) who exhibit complex conditions characterized by rare and severe anomalies in skeletal development. These abnormalities may affect bones, joints, and musculotendinous structures.",[13],"Procedure: Deformity correction",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Deformity correction","Surgeries to correct bone defomity, supported by the use of preoperative planning and\u002For patient-specific instruments",[9],null,[22,26,29,32,35,38],{"name":23,"affiliation":24,"role":25},"Pierfrancesco Costici, MD","Ospedale Pediatrico Bambin Gesù","PRINCIPAL_INVESTIGATOR",{"name":27,"affiliation":28,"role":25},"Giorgio Marrè Brunenghi, MD","Istituto Giannina Gaslini",{"name":30,"affiliation":31,"role":25},"Fabio Verdoni, MD","Galeazzi Orthopedic Institute",{"name":33,"affiliation":34,"role":25},"Roberto Biagini, MD","Istituto Nazionale Tumori Regina Elena",{"name":36,"affiliation":37,"role":25},"Gianluigi Pasta, MD","Policlinico San Matteo",{"name":39,"affiliation":40,"role":25},"Tommaso Bonanzinga, MD","Istituto Clinico Humanitas",[42,48],{"name":43,"role":44,"phone":45,"phoneExt":46,"email":47},"Grazia Chiara Menozzi","CONTACT","0516366","484","graziachiara.menozzi@ior.it",{"name":49,"role":44,"phone":45,"phoneExt":46,"email":50},"Giovanni Trisolino, MD","giovanni.trisolino@ior.it",[52,69,81,91,101,110,120],{"facility":53,"status":54,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"IRCCS Istituto Ortopedico Rizzoli","RECRUITING","Bologna","BO","40136","Italy","IT",{"type":61,"coordinates":62},"Point",[63,64],11.33875,44.49381,{"lat":64,"lon":63},[67],{"name":43,"role":44,"phone":68,"phoneExt":46,"email":47},"0516266",{"facility":40,"status":70,"city":71,"state":72,"zip":20,"country":58,"countryCode":59,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"NOT_YET_RECRUITING","Rozzano","MI",{"type":61,"coordinates":74},[75,76],9.1559,45.38193,{"lat":76,"lon":75},[79],{"name":39,"role":44,"phone":20,"phoneExt":20,"email":80},"tommaso.bonanzinga@hunimed.eu",{"facility":28,"status":70,"city":82,"state":20,"zip":20,"country":58,"countryCode":59,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"Genova",{"type":61,"coordinates":84},[85,86],11.87211,45.21604,{"lat":86,"lon":85},[89],{"name":27,"role":44,"phone":20,"phoneExt":20,"email":90},"giorgiomarre@gaslini.org",{"facility":31,"status":70,"city":92,"state":20,"zip":20,"country":58,"countryCode":59,"cosmosGeoPoint":93,"geoPoint":97,"contacts":98},"Milan",{"type":61,"coordinates":94},[95,96],12.59836,42.78235,{"lat":96,"lon":95},[99],{"name":30,"role":44,"phone":20,"phoneExt":20,"email":100},"fabio.verdoni@grupposandonato.it",{"facility":37,"status":70,"city":102,"state":20,"zip":20,"country":58,"countryCode":59,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"Pavia",{"type":61,"coordinates":104},[105,106],9.15917,45.19205,{"lat":106,"lon":105},[109],{"name":36,"role":44,"phone":20,"phoneExt":20,"email":20},{"facility":34,"status":70,"city":111,"state":20,"zip":20,"country":58,"countryCode":59,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"Roma",{"type":61,"coordinates":113},[114,115],11.10642,44.99364,{"lat":115,"lon":114},[118],{"name":33,"role":44,"phone":20,"phoneExt":20,"email":119},"roberto.biagini@ifo.it",{"facility":121,"status":70,"city":111,"state":20,"zip":20,"country":58,"countryCode":59,"cosmosGeoPoint":122,"geoPoint":124,"contacts":125},"Ospedale Pediatrico Bambino Gesù",{"type":61,"coordinates":123},[114,115],{"lat":115,"lon":114},[126],{"name":127,"role":44,"phone":20,"phoneExt":20,"email":128},"Pier Francesco Costici, MD","pierfrancesco.costici@opbg.net",{"type":130,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[132,134,135,136,137,138],{"name":121,"class":133},"UNKNOWN",{"name":28,"class":6},{"name":31,"class":133},{"name":34,"class":133},{"name":37,"class":133},{"name":40,"class":6},"100545332","advanced-surgical-simulation-processes-in-the-correction-of-skeletal-defects-and-deformities-100545332",false,"NCT06380530","Advanced Surgical Simulation Processes in the Correction of Skeletal Defects and Deformities","SIMULA","Inclusion Criteria:\n\n* Diagnosis of musculoskeletal disease (MSD) of the limbs;\n* Need for mono- or polyaxial correction by one or more osteotomies;\n* Presence of specific consent to participate in the trial;\n\nExclusion Criteria:\n\n* Patients who refuse to participate in the study\n* Patients who do not undergo radiological follow-up examinations for VSP or for whom the radiological record is insufficient to conduct VSP;\n* Patients who undergo different interventions for correction of MSD (growth modulation interventions by epiphysiodesis and hemiepiphysiodesis, progressive correction by external circular\u002Fhexapodal fixation);\n* Pregnant or lactating women","ALL","2 Years","40 Years",{"count":150,"type":151},100,"ESTIMATED","INTERVENTIONAL",[154],"NA","Virtual Surgical Planning (VSP), Computer-Aided Surgical Simulation (CASS) for bone corrections, and the customization of implants and devices through 3D printing, known as Patient-Specific Instruments (PSI) and Graft-Specific Instruments (GSI), are assuming increasingly central roles in orthopedic clinical and surgical practice.\n\nOne area witnessing notable advancement is the treatment of musculoskeletal disorders (MMS) in children, adolescents, and young adults. These disorders involve severe and rare abnormalities in skeletal formation and development across three-dimensional planes, often affecting multiple limbs. Managing such deformities is complex, challenging to standardize, and prone to unpredictable clinical, radiographic, and functional outcomes.\n\nThe application of 3D modeling and printing technologies offers a deeper understanding of deformities and facilitates improved prediction, precision, reproducibility, and safety in surgical interventions.\n\nThe Musculoskeletal Apparatus Network (RAMS Network) centers are equipped with advanced 3D laboratories for surgical simulation and planning, aligned with the overarching goal of improving surgery quality through \"in-silico\" medicine (ISM) principles.\n\nAt present, numerous complex surgeries involving Virtual Surgical Planning (VSP) and sterilizable 3D-printed Patient-Specific Instruments (PSI) and\u002For Graft-Specific Instruments (GSI) are being simulated and performed at the Rizzoli Institute. Preliminary data from previous protocols indicate a significant reduction in surgical time with the implementation of VSP and the utilization of PSI and GSI.\n\nThe aim of this study is to enhance the current process of simulating, planning, and designing surgical support tools within 3D Printing Point-of-Care (3D POC) facilities. To achieve this, it is imperative to expand case volumes and systematically organize, categorize, and standardize simulation and planning procedures.",[157,158,159],"Musculoskeletal Deformity","Musculoskeletal Abnormalities","Musculoskeletal Disorder",[161,162,163,164],"Virtual Surgical Planning","Patient-Specific instrument","Graft-Specific instrument","Pediatric Orthopedics","2025-12-19",{"date":167,"type":168},"2025-12-26","ACTUAL",{"date":170,"type":168},"2024-10-31",{"date":172,"type":151},"2029-05",{"name":5,"class":6},7]