[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617803":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":39,"responsibleParty":121,"collaborators":25,"id":124,"slug":125,"hasResults":126,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":126,"sex":132,"minAge":133,"maxAge":25,"enrollmentInfo":134,"targetDuration":25,"studyType":137,"phases":138,"briefSummary":140,"conditions":141,"keywords":144,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":153,"completionDateStruct":154,"leadSponsor":156,"locationsCount":157},{"fullName":5,"class":6},"Beijing Tiantan Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Endovascular treatment (EVT) +Best medical treatment","EXPERIMENTAL","The treating physician should attempt to perform EVT with the goal to restore blood flow to the affected vascular territory immediately after randomisation. EVT included thrombectomy with stent retrievers, thromboaspiration, intraarterial thrombolysis, balloon angioplasty, stenting, or a combination of these approaches at the discretion of the interventional team. All decisions regarding the performance of EVT are made by the treating physician, based on his\u002Fher own judgement, and using local standards for endovascular treatment technique and devices and\u002For medications used for EVT. All other treatments (especially after-care and best medical treatment) will not differ between the intervention and control group.",[13],"Procedure: Endovascular treatment",{"label":15,"type":6,"description":16,"interventionNames":17},"Best medical treatment (BMT)","Administration of BMT should be done according to routine clinical practice and current guidelines.",[18],"Drug: Best medical treatment (BMT)",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Endovascular treatment","EVT included thrombectomy with stent retrievers, thromboaspiration, intraarterial thrombolysis, balloon angioplasty, stenting, or a combination of these approaches at the discretion of the interventional team.",[9],null,{"type":27,"name":15,"description":28,"armGroupLabels":29,"otherNames":25},"DRUG","Administration of BMT should be done according to routine clinical practice and current international guidelines. Administration of BMT must not be delayed by randomisation and should be done independently from participation in this trial.",[15],[31],{"name":32,"affiliation":5,"role":33},"Yunyun Xiong, professor","PRINCIPAL_INVESTIGATOR",[35],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","86-10-59978350","xiongyunyun@bjtth.org",[40,56,66,80,94,107],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Beijing tiantan hospital","RECRUITING","Beijing","Beijing Municipality","100070","China","CN",{"type":49,"coordinates":50},"Point",[51,52],116.39723,39.9075,{"lat":52,"lon":51},[55],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},{"facility":57,"status":42,"city":43,"state":44,"zip":25,"country":46,"countryCode":47,"cosmosGeoPoint":58,"geoPoint":60,"contacts":61},"Beijing Daxing District People's Hospital",{"type":49,"coordinates":59},[51,52],{"lat":52,"lon":51},[62],{"name":63,"role":36,"phone":64,"phoneExt":25,"email":65},"Chunmiao Duan","010-60283006","miao3252003@163.com",{"facility":67,"status":42,"city":68,"state":69,"zip":25,"country":46,"countryCode":47,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"Xingtang County People's Hospital","Longzhou","Hebei",{"type":49,"coordinates":71},[72,73],114.54953,38.43814,{"lat":73,"lon":72},[76],{"name":77,"role":36,"phone":78,"phoneExt":25,"email":79},"Yanxin Wang","0311-82981231","bdaczfg@163.COM",{"facility":81,"status":42,"city":82,"state":83,"zip":25,"country":46,"countryCode":47,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Luoyang Yiluo Hospital","Luoyang","Henan",{"type":49,"coordinates":85},[86,87],112.43684,34.67345,{"lat":87,"lon":86},[90],{"name":91,"role":36,"phone":92,"phoneExt":25,"email":93},"Yajun Yang","0379-82888808","sqyyj7119@163.com",{"facility":95,"status":42,"city":96,"state":83,"zip":25,"country":46,"countryCode":47,"cosmosGeoPoint":97,"geoPoint":101,"contacts":102},"People's Hospital of Queshan","Panlong",{"type":49,"coordinates":98},[99,100],114.01917,32.80222,{"lat":100,"lon":99},[103],{"name":104,"role":36,"phone":105,"phoneExt":25,"email":106},"Jianxin Xu","0396-7068021","249957242@qq.com",{"facility":108,"status":42,"city":109,"state":110,"zip":25,"country":46,"countryCode":47,"cosmosGeoPoint":111,"geoPoint":115,"contacts":116},"Changle People's Hospital","Changle","Shandong",{"type":49,"coordinates":112},[113,114],118.8275,36.70583,{"lat":114,"lon":113},[117],{"name":118,"role":36,"phone":119,"phoneExt":25,"email":120},"Ruiguang Liu","0536-6222822","lrgys@126.com",{"type":33,"investigatorFullName":122,"investigatorTitle":123,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Yunyun Xiong","Professor","100617803","advancing-reperfusion-therapy-for-ischemic-stroke-perfusion-guided-endovascular-intervention-for-medium-vessel-occlusion-therapy-100617803",false,"NCT07323368","Advancing Reperfusion Therapy for Ischemic Stroke: Perfusion-guided Endovascular Intervention for Medium Vessel Occlusion Therapy","Advancing Reperfusion Therapy for Ischemic Stroke (ARTS): Perfusion-guided Endovascular Intervention for Medium Vessel Occlusion Therapy (PIVOT)","ARTS-PIVOT","Inclusion Criteria:\n\n* Age≥18 years old;\n* Acute ischemic stroke symptom onset within 24 hours; including wake-up stroke and unwitnessed stroke, onset time refers to \"last-seen normal time\";\n* Primary medium vessel occlusions confirmed by CTA\u002FMRA, including non-dominant proximal M2 or mid-distal M2\u002FM3 segments of the middle cerebral artery (MCA), A1\u002FA2\u002FA3 segments of the anterior cerebral artery (ACA), and P1\u002FP2\u002FP3 segments of the posterior cerebral artery (PCA) and responsible for the signs and symptoms of acute ischemic stroke;\n* Pre-stroke modified Rankin scale (mRS) score ≤1;\n* Baseline National Institutes of Health Stroke Scale (NIHSS) ≥8;\n* Neuroimaging criteria: Target mismatch profile on CT perfusion or MRI+MR perfusion (ischemic core volume \\\u003C70 mL, mismatch rate \\>1.2, mismatch volume \\>10 mL);\n* Written informed consent from patients or their legally authorized representatives.\n\nExclusion Criteria:\n\n* Any evidence of intracranial hemorrhage on qualifying imaging;\n* Known (serious) sensitivity to radiographic contrast agents, nickel, titanium metals or their alloys and unable to complete CTP\u002FPWI;\n* Known history of arterial tortuosity, pre-existing stent, other arterial disease and\u002For known disease at the arterial access site that would prevent the device from reaching the target vessel and\u002For preclude safe recovery after EVT;\n* Radiological confirmed evidence of mass effect or intracranial tumour (except small meningioma);\n* Clinical diagnosis of cerebral vasculitis;\n* Evidence of vessel recanalization prior to randomisation;\n* Severe comorbidities, which will likely prevent improvement or follow-up;\n* Any terminal illness such that the patient would not be expected to survive more than 1 year;\n* Hypodensity in \\>1\u002F3 MCA territory on non-contrast CT or significant hypodensity outside the current perfusion lesion suggesting distal clot migration (secondary MeVO);\n* Multiple arterial occlusion;\n* Pregnant women, nursing mothers, or reluctance to use effective contraceptive measures during the period of the trial;\n* Unlikely to adhere to the trial protocol or follow-up;\n* Participation in other interventional clinical trials within the previous 3 months.","ALL","18 Years",{"count":135,"type":136},568,"ESTIMATED","INTERVENTIONAL",[139],"NA","The investigators initiated a multicenter, prospective, randomized, open label, blinded-endpoint (PROBE) controlled trial to evaluate the efficacy and safety of perfusion-guided endovascular treatment (EVT) compared to standard medical care for patients with acute ischemic stroke due to medium vessel occlusion (MeVO) within 24 hours from symptom onset.",[142,143],"Stroke Ischemic","Medium Vessel Occlusions",[145,146,147,148],"ischemic stroke","medium vessel occlusions","endovascular treatment","perfusion imaging","2026-02-08",{"date":151,"type":152},"2026-02-10","ACTUAL",{"date":149,"type":152},{"date":155,"type":136},"2028-09-30",{"name":5,"class":6},6]