[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604648":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":37,"responsibleParty":60,"collaborators":12,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":12,"enrollmentInfo":72,"targetDuration":12,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":39,"whyStopped":12,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Vanderbilt University Medical Center","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Control","NO_INTERVENTION","No intervention will be delivered.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Anesthesia Workflow-Driven Clinical Decision Support (AW-D CDS) Tool Intervention","EXPERIMENTAL","The AW-D CDS Tool will test the delivery of PONV prophylaxis with the use of the clinical decision support tool. When a patient meets the study study criteria, the AW-D CDS Tool will provide automated notification through the electronic health system.\n\nThe automated notifications be triggered and linked to the point-of-care\u002Fdesired time of PONV medication administration throughout the workflow of the anesthetic case to optimize the timing of PONV medication administration (pre-procedure evaluation, post-induction, pre-emergence).\n\nThe provider is not forced to follow the recommendations, rather it serves as a reminder of best practices as defined by our department.\n\nThe intervention will be assessed using a repeated cross-over design at the institutional level with periods of time for washout, control and study intervention.",[18],"Other: AW-D Clinical Decision Support Tool",[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":12},"AW-D Clinical Decision Support Tool","The AW-D Clinical Decision Support Tool will test the automatic delivery of best practice advisories for antiemetic medications at critical timepoints in the perioperative period.",[14],[25],{"name":26,"affiliation":5,"role":27},"Miklos Kertai, M.D., Ph.D.","PRINCIPAL_INVESTIGATOR",[29,33],{"name":26,"role":30,"phone":31,"phoneExt":12,"email":32},"CONTACT","615-875-0378","miklos.kertai@vumc.org",{"name":34,"role":30,"phone":35,"phoneExt":12,"email":36},"Gail Mayo","615-936-1705","gail.mayo@vumc.org",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Nashville","Tennessee","37212","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-86.78444,36.16589,{"lat":49,"lon":48},[52,54,57],{"name":53,"role":30,"phone":12,"phoneExt":12,"email":32},"Miklos Kertai, MD",{"name":55,"role":30,"phone":12,"phoneExt":12,"email":56},"Ellen Stallings","ellen.stallings@vumc.org",{"name":58,"role":59,"phone":12,"phoneExt":12,"email":12},"Ellen Stallings, MD","SUB_INVESTIGATOR",{"type":27,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Miklos Kertai","Professor Cardiothoracic Anesthesiology, Vice Chair Perioperative Medicine, Director Perioperative Precision Medicine Program","100604648","advancing-strategies-to-optimize-the-perioperative-management-of-postoperative-nausea-and-vomiting-aspire-ponv-trial-100604648",false,"NCT07152249","Advancing Strategies to Optimize the PerIopeRativE Management of PostOperative Nausea and Vomiting (ASPIRE-PONV) Trial","ASPIRE-PONV","Adult Inclusion Criteria\n\n* Age ≥ 18 years\n* Planned surgery with general anesthesia with endotracheal intubation or laryngeal mask airway\n* Meet zero or more risk factors for PONV ( history of motion sickness or postoperative nausea and vomiting, non-smoker, female sex, duration of inhalation anesthesia greater than 1 hour, undergoing high risk surgical procedure (cholecystectomy, laparoscopy, gynecologic), and perioperative opioid use)\n\nAdult Exclusion Criteria\n\n* ASA 6 including organ procurement,\n* Patients anticipated to be transferred directly to the intensive care unit intubated,\n* Procedure types:\n\n  * Electroconvulsive therapy,\n  * Intubation only cases,\n  * labor epidurals,\n  * transesophageal echocardiography (TEE)\u002Fcardioversion,\n  * surgery duration \\\u003C 30 minutes.\n\nOperating Room Anaesthesia Provider Inclusion Criteria\n\nAny operating room anaesthesia provider of eligible patients will be included.","ALL","18 Years",{"count":73,"type":74},19480,"ESTIMATED","INTERVENTIONAL",[77],"NA","The goal of this prospective, unblinded, pragmatic and repeated crossover trial is to learn if clinical decision support alerts will impact postoperative nausea and vomiting (PONV) prophylaxis and reduce PONV rates in adult patients who have planned surgery with general anesthesia. The main aim is to improve PONV, establishing a scalable Clinical Decision Support (CDS) Tool for personalized PONV prevention.\n\nThe primary hypothesis is that, compared with standard care, the Anesthesia Workflow-Driven Clinical Decision Support Tool for Personalized PONV Prevention will be associated with a significant improvement in the rate of appropriate administration of PONV prophylaxis and a significant decrease in the incidence of PONV.\n\nThis study will evaluate a new clinical decision support (CDS) tool designed to improve how and when PONV prevention strategies are used. Unlike traditional tools that provide generic, one-time alerts, this new system is integrated into the electronic health record (EHR) and delivers timely, targeted reminders to anesthesia providers at key moments during a patient's surgical care-such as before surgery begins, after anesthesia is given, and before the patient wakes up. These alerts are based on each patient's individual risk for PONV and are intended to support, not replace, clinical judgment. The study will use a crossover design over 12 months, alternating between periods when the tool is active and when it is not. The goal is to determine whether this time-sensitive, workflow-integrated tool can lead to better adherence to best practices and improved patient outcomes.",[80,81],"Postoperative Nausea","Postoperative Vomiting",[83],"clinical decision support","2026-01-09",{"date":86,"type":87},"2026-01-12","ACTUAL",{"date":89,"type":87},"2025-09-03",{"date":91,"type":74},"2026-09",{"name":5,"class":6},1]