[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591188":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":30,"responsibleParty":48,"collaborators":50,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":20,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":20,"overallStatus":33,"whyStopped":20,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"University of North Carolina, Chapel Hill","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Trier Social Stress Test (TSST)","EXPERIMENTAL","The Trier Social Stress Test for Children (TSST-C) is a social stressor involving story telling in front of two neutral judges, preparation time and a cognitive stressor involving mental arithmetic-counting backward from 1023 by 13s. It is used to elicit physiological stress responses. The TSST-C is administered in 4 parts: an anticipatory stress phase (5 min to prepare the speech); the speech task (5 min), the arithmetic task (5 min), and the recovery phase (up through 40 min post-task).",[13],"Behavioral: Trier Social Stress Test",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Trier Social Stress Test","Psychosocial stress procedure; 5 minutes of public speaking (preceded by 5 minutes of preparation) and 5 minutes of mental arithmetic.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Aysenil Belger, PhD","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","(919)-260-9822‬","aysenil.belger@unc.edu",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"The University of North Carolina at Chapel Hill School of Medicine","RECRUITING","Chapel Hill","North Carolina","27599","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-79.05584,35.9132,{"lat":43,"lon":42},[46,47],{"name":23,"role":27,"phone":20,"phoneExt":20,"email":29},{"name":23,"role":24,"phone":20,"phoneExt":20,"email":20},{"type":49,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[51,54],{"name":52,"class":53},"National Institute on Drug Abuse (NIDA)","NIH",{"name":55,"class":6},"RTI International","100591188","adverse-adolescent-pathways-to-substance-use-100591188",false,"NCT06977178","Adverse Adolescent Pathways to Substance Use","APSU","Inclusion Criteria:\n\n* Male or female\n* 12-14 years old,\n* Report symptoms of anxiety\n* Understand and sign an assent, and parents will sign a permission and a consent document in English\n* Meets study hearing and vision requirements\n* Substance use naïve\n\nExclusion Criteria:\n\n* Has any foreign metal objects or implants as determined by the safety questionnaires (e.g., bone screws, shunts or body piercing that can't be removed, etc.)\n* Has been diagnosed with psychosis or a severe emotional disturbance.\n* Has used alcohol, tobacco, or marijuana more than 3 times.\n* Is pregnant. Girls who self-report pregnancy may not participate in the stress evaluation or the MRI scan.\n* Is taking any medications that directly alter cardiovascular function (e.g., propranolol or other beta blockers).\n* Any current or lifetime treatment with antipsychotic medication.\n* Has had a head injury that resulted in a loss of consciousness for more than 5 minutes.\n* Is planning to get non-removable metal braces.\n* Impaired intellectual functioning (full-scale intelligence quotient \\\u003C70).\n* Past or current history of a clinically significant central nervous system that could confound brain imaging evaluations.",true,"ALL","12 Years","14 Years",{"count":68,"type":69},180,"ESTIMATED","INTERVENTIONAL",[72],"NA","Purpose: This 5-year R01 study will elucidate the role of maturational change across adolescence in neural connectivity and physiological stress responses in the relationship between anxiety and adverse pathways to substance use (APSU). Participants: Children (N=200) aged 12-14 with symptoms of anxiety and their legal caregiver will be recruited from clinical and community sources. Procedures: Youth participants will complete several questionnaires and interviews, undergo neuroimaging while performing cognitive tasks, and have their heart rate and skin conductance monitored during a mildly stressful task. Caregivers will complete several questionnaires.",[75,76,77],"Anxiety","Adolescent Development","Substance Use","2025-05-08",{"date":80,"type":81},"2025-05-18","ACTUAL",{"date":83,"type":81},"2024-02-20",{"date":85,"type":69},"2030-06-30",{"name":5,"class":6},1]