[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630263":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":25,"responsibleParty":43,"collaborators":25,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":25,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":25,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":72,"whyStopped":25,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":25},{"fullName":5,"class":6},"Universidad Complutense de Madrid","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Group: Extensive Continuous Training","ACTIVE_COMPARATOR","Participants assigned to this arm will undergo an 8-week continuous aerobic training program on a cycle ergometer, with two supervised 90-minute sessions per week.\n\nEach session includes:\n\nWarm-up (10-15 minutes) consisting of low-intensity pedaling (≤60% max HR) and joint mobility exercises.\n\nMain training block: 40 minutes of continuous cycling at moderate intensity (65-75% max HR), individually adjusted based on baseline assessment.\n\nCool-down (5-10 minutes) with light pedaling and gentle stretching. Additionally, all participants will complete a standardized strength-resistance and mobility training program supervised by specialized physiotherapists, identical for both groups, including controlled exercises with bodyweight and light resistance.",[13],"Other: Control Group (A):",{"label":15,"type":16,"description":17,"interventionNames":18},"Long Extensive Interval Training","EXPERIMENTAL","Participants assigned to this arm will complete an 8-week aerobic interval training program on a cycle ergometer, with two supervised 90-minute sessions weekly.\n\nEach session includes:\n\nWarm-up (10-15 minutes) of low-intensity pedaling (≤60% max HR) and joint mobility exercises.\n\nMain training block: 8 intervals of 3 minutes at high subthreshold intensity (75-85% max HR), alternating with 2 minutes of active recovery at low-to-moderate intensity (65-70% max HR), totaling approximately 40 minutes.\n\nCool-down (5-10 minutes) with light pedaling and stretching. As in the other group, all participants will engage in a standardized strength-resistance and mobility program identical across groups.",[19],"Other: Intervention Group",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Intervention Group","Participants will undergo an 8-week aerobic interval training program on a cycle ergometer, consisting of two weekly supervised sessions of 90 minutes. Each session includes:\n\nWarm-up: 10-15 minutes of low-intensity continuous pedaling (≤60% max HR) and joint mobility exercises.\n\nMain aerobic interval training: 8 intervals of 3 minutes pedaling at 75-85% of maximum heart rate, each followed by 2 minutes of active recovery at 65-70% max HR. Total aerobic training duration approximately 40 minutes.\n\nCool-down: 5-10 minutes of light pedaling and stretching.\n\nHeart rate, blood pressure, and oxygen saturation will be continuously monitored. Safety criteria for session interruption will be applied.",[15],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Control Group (A):","Participants will complete an 8-week continuous aerobic training program on a cycle ergometer, with two weekly supervised 90-minute sessions, including:\n\nWarm-up: 10-15 minutes of low-intensity continuous pedaling (≤60% max HR) and joint mobility exercises.\n\nMain aerobic continuous training: 40 minutes of continuous pedaling at 65-75% of maximum heart rate.\n\nCool-down: 5-10 minutes of light pedaling and stretching.\n\nMonitoring and safety procedures as in the intervention group.",[9],[31],{"name":32,"affiliation":33,"role":34},"Gustavo Plaza-Manzano, PhD","Faculty of Nursing, Physiotherapy and Podiatry. Universidad Complutense de Madrid","STUDY_DIRECTOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Isidro Fernández-López, PhD","CONTACT","+34625598970","isidrofe@ucm.es",{"name":42,"role":38,"phone":25,"phoneExt":25,"email":25},"Alberto Martos-Monedero, PT",{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Isidro Fernández López","PT, PhD.","100630263","aerobic-interval-vs-continuous-training-on-heart-rate-power-decoupling-in-ischemic-heart-disease-100630263",false,"NCT07485400","Aerobic Interval vs Continuous Training on Heart Rate-Power Decoupling in Ischemic Heart Disease","Effects of Long Extensive Aerobic Interval Training Versus Long Extensive Continuous Training on Heart Rate-Power Decoupling in Patients With Ischemic Heart Disease: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Confirmed diagnosis of cardiovascular disease requiring cardiac rehabilitation, with medical indication for a supervised exercise training program.\n* Prognostic risk classified as low or moderate according to the clinical risk stratification established in the unit, considering:\n\n  * Killip class I or II (absence or mild heart failure)¹.\n  * Absence of recent acute myocardial infarction (\\\u003C 1 month) or presence of a stable previous infarction.\n  * Stable and well-controlled cardiovascular symptoms.\n  * Physical capacity demonstrated in functional tests ≥ 5 METs, preferably \\> 7 METs for low-risk patients.\n* Age between 40 and 75 years.\n* Ability to perform physical exercise without absolute contraindications.\n* Written informed consent and willingness to attend the scheduled sessions twice per week for 8 weeks.\n\nExclusion Criteria:\n\n* High prognostic risk, defined by:\n\n  * Killip class \\> III (moderate to severe heart failure).\n  * Recent acute myocardial infarction (\\\u003C 1 month) with clinical instability.\n  * Active anginal symptoms or decompensated heart failure.\n  * Physical capacity \\\u003C 5 METs on functional testing, indicating severely reduced exercise capacity.\n* Presence of complex or unstable arrhythmias contraindicating vigorous physical exercise.\n* Concomitant diseases that may limit participation or compromise safety (e.g., advanced pulmonary disease, severe renal failure, severe neuromuscular disorders).\n* Absolute medical contraindications to maximal strength or interval training (e.g., aortic aneurysm, uncontrolled hypertension).\n* Participation in another clinical trial or concurrent rehabilitation program.\n* Inability to comply with attendance requirements or to follow the intervention protocol.","ALL","40 Years","75 Years",{"count":58,"type":59},48,"ESTIMATED","INTERVENTIONAL",[62],"NA","This study is a randomized, parallel-group clinical trial with assessor and statistical analyst blinding, conducted at a single center. Participants with stable ischemic heart disease enrolled in a cardiac rehabilitation program will be randomly allocated to one of two aerobic exercise interventions: long extensive continuous aerobic training (zone 2) or long extensive aerobic interval training (zone 3). Both groups will participate in supervised exercise sessions twice weekly for a period of 8 weeks, integrated into the standard cardiac rehabilitation program.\n\nAssessments will be performed at baseline, immediately after the intervention period (8 weeks), and after a 4-week follow-up period without supervised training to evaluate potential detraining effects. The primary outcome is heart rate-power decoupling during a prolonged submaximal cycling exercise test, used as an indicator of cardiovascular efficiency. Secondary outcomes include heart rate response during submaximal exercise, exercise tolerance, heart rate recovery, blood pressure, functional capacity, quality of life, and adherence to the training program.\n\nThe objective of this study is to compare the effects of long extensive aerobic interval training versus long extensive continuous training on heart rate-power decoupling and related cardiovascular and functional outcomes in patients with ischemic heart disease undergoing cardiac rehabilitation.",[65],"Stable Coronary Artery Disease (CAD), Myocardial Infarction",[67,68,69,70,71],"Cardiac rehabilitation","High-Intensity Interval Training","Coronary Artery Disease","Exercise Therapy","Myocardial Infarction","NOT_YET_RECRUITING","2026-03-16",{"date":75,"type":76},"2026-03-20","ACTUAL",{"date":78,"type":59},"2026-03-17",{"date":80,"type":59},"2026-07-03",{"name":5,"class":6}]