[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100255479":3},{"organization":4,"armGroups":7,"interventions":46,"overallOfficials":117,"centralContacts":121,"locations":130,"responsibleParty":158,"collaborators":160,"id":163,"slug":10,"hasResults":164,"nctId":165,"briefTitle":166,"officialTitle":166,"acronym":10,"eligibilityCriteria":167,"healthyVolunteers":168,"sex":169,"minAge":170,"maxAge":10,"enrollmentInfo":171,"targetDuration":10,"studyType":174,"phases":10,"briefSummary":175,"conditions":176,"keywords":10,"overallStatus":132,"whyStopped":10,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":190},{"fullName":5,"class":6},"Washington University School of Medicine","OTHER",[8,29,32,36,41],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm A: Clonal hematopoiesis",null,"* Complete several self-administered health assessments at baseline and every 6 months until death.\n* Cognitive assessment, Gait Speed, grip strength, blood pressure, height, and weight will be performed by a member of the research team at baseline and every 6 months until death.\n* Peripheral blood draw will occur at baseline and no more than every 6 months until death.\n* Buccal swabs will occur at baseline and repeated as necessary, but not more than every 6 months until death\n* May be approached about optional bone marrow biopsy",[13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28],"Other: Cognitive Assessment","Other: Activities of Daily Living Questionnaire","Other: Instrumental Activities of Daily Living, subscale of the OARS","Other: Karnofsky Self-reported Performance Rating Scale","Other: Number of Falls","Other: Physical Health Section, subscale of the OARS","Other: MOS Social Activity Survey","Other: Unintentional Weight Loss","Genetic: Peripheral Blood Draw","Genetic: Buccal Swab","Other: Heart Health and Smoking History from BRFSS questionnaire","Other: Gait Speed","Other: Grip Strength","Other: Height and Weight measurements","Other: Blood pressure measurement","Procedure: Optional bone marrow biopsy",{"label":30,"type":10,"description":11,"interventionNames":31},"Arm B: No clonal hematopoiesis",[13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28],{"label":33,"type":10,"description":34,"interventionNames":35},"Arm C: No clonal hematopoiesis & no follow-up","* Complete several self-administered health assessments at baseline with no further follow-up\n* Cognitive assessment, Gait Speed, grip strength, blood pressure, height, and weight will be performed by a member of the research team at baseline with no further follow-up\n* Peripheral blood draw will occur at baseline with no further follow-up\n* Buccal swabs will occur at baseline with no further follow-up",[13,14,15,16,17,18,19,20,21,22,23,24,25,26,27],{"label":37,"type":10,"description":38,"interventionNames":39},"Arm D: Hip replacement","-Participants undergoing a hip replacement will be asked to donate their femur head that would otherwise be discarded for cell harvesting\u002Fbanking and DNA sequencing. They are not required to complete any other study procedures.",[40],"Other: Femur head donation",{"label":42,"type":10,"description":43,"interventionNames":44},"Arm E: Trauma","-Blood sample at the time of admission with initial bloodwork. For inpatient participants, weekly follow-up samples will be drawn with morning phlebotomy. A follow-up sample collection will occur 4-7 weeks after discharge.",[45],"Procedure: Blood draw for trauma measurements",[47,51,55,59,63,66,70,74,78,82,86,90,94,98,101,104,109,113],{"type":6,"name":48,"description":49,"armGroupLabels":50,"otherNames":10},"Cognitive Assessment","-Baseline and no more frequently than every 6 months until death",[9,30,33],{"type":6,"name":52,"description":53,"armGroupLabels":54,"otherNames":10},"Activities of Daily Living Questionnaire","* 10 items about daily functional status\n* Baseline and no more frequently than every 6 months until death",[9,30,33],{"type":6,"name":56,"description":57,"armGroupLabels":58,"otherNames":10},"Instrumental Activities of Daily Living, subscale of the OARS","* 7 items about daily functional status\n* Baseline and no more frequently than every 6 months until death",[9,30,33],{"type":6,"name":60,"description":61,"armGroupLabels":62,"otherNames":10},"Karnofsky Self-reported Performance Rating Scale","* 1 item about daily functional status\n* Baseline and no more frequently than every 6 months until death",[9,30,33],{"type":6,"name":64,"description":61,"armGroupLabels":65,"otherNames":10},"Number of Falls",[9,30,33],{"type":6,"name":67,"description":68,"armGroupLabels":69,"otherNames":10},"Physical Health Section, subscale of the OARS","* 13 items about comorbidity\n* Baseline and no more frequently than every 6 months until death",[9,30,33],{"type":6,"name":71,"description":72,"armGroupLabels":73,"otherNames":10},"MOS Social Activity Survey","* 4 items about social activity\n* Baseline and no more frequently than every 6 months until death",[9,30,33],{"type":6,"name":75,"description":76,"armGroupLabels":77,"otherNames":10},"Unintentional Weight Loss","* 2 items about nutrition\n* Baseline and no more frequently than every 6 months until death",[9,30,33],{"type":79,"name":80,"description":49,"armGroupLabels":81,"otherNames":10},"GENETIC","Peripheral Blood Draw",[9,30,33],{"type":79,"name":83,"description":84,"armGroupLabels":85,"otherNames":10},"Buccal Swab","* Participants will rinse their mouths 2 times with water for 20-30 seconds and discard the expectorated sample. One side of the inner cheek (buccal mucosa) will then be scraped with a cotton swab 20 times (alternatively, the tongue will be brushed 20 times with a toothbrush)\n* Baseline and no more frequently than every 6 months until death",[9,30,33],{"type":6,"name":87,"description":88,"armGroupLabels":89,"otherNames":10},"Heart Health and Smoking History from BRFSS questionnaire","* 7 items about heart health and smoking history\n* Baseline and no more frequently than every 6 months until death",[9,30,33],{"type":6,"name":91,"description":92,"armGroupLabels":93,"otherNames":10},"Gait Speed","* Research coordinator will test gait speed\n* Baseline and no more frequently than every 6 months until death",[9,30,33],{"type":6,"name":95,"description":96,"armGroupLabels":97,"otherNames":10},"Grip Strength","* Research coordinator will test grip strength\n* Baseline and no more frequently than every 6 months until death",[9,30,33],{"type":6,"name":99,"description":49,"armGroupLabels":100,"otherNames":10},"Height and Weight measurements",[9,30,33],{"type":6,"name":102,"description":49,"armGroupLabels":103,"otherNames":10},"Blood pressure measurement",[9,30,33],{"type":105,"name":106,"description":107,"armGroupLabels":108,"otherNames":10},"PROCEDURE","Optional bone marrow biopsy","-1 optional bone marrow biopsy",[9,30],{"type":105,"name":110,"description":111,"armGroupLabels":112,"otherNames":10},"Blood draw for trauma measurements","-For Arm E only",[42],{"type":6,"name":114,"description":115,"armGroupLabels":116,"otherNames":10},"Femur head donation","Hip replacement participants only",[37],[118],{"name":119,"affiliation":5,"role":120},"Meagan Jacoby, M.D.","PRINCIPAL_INVESTIGATOR",[122,126],{"name":119,"role":123,"phone":124,"phoneExt":10,"email":125},"CONTACT","314-747-8439","mjacoby@wustl.edu",{"name":127,"role":123,"phone":128,"phoneExt":10,"email":129},"Kristina Williams, B.S.","314-362-6963","kjw1@wustl.edu",[131],{"facility":5,"status":132,"city":133,"state":134,"zip":135,"country":136,"countryCode":137,"cosmosGeoPoint":138,"geoPoint":143,"contacts":144},"RECRUITING","St Louis","Missouri","63110","United States","US",{"type":139,"coordinates":140},"Point",[141,142],-90.19789,38.62727,{"lat":142,"lon":141},[145,146,148,149,152,154,156],{"name":119,"role":123,"phone":124,"phoneExt":10,"email":125},{"name":147,"role":123,"phone":128,"phoneExt":10,"email":129},"Kristi Williams, B.S.",{"name":119,"role":120,"phone":10,"phoneExt":10,"email":10},{"name":150,"role":151,"phone":10,"phoneExt":10,"email":10},"Timothy Ley, M.D.","SUB_INVESTIGATOR",{"name":153,"role":151,"phone":10,"phoneExt":10,"email":10},"Matthew Walter, M.D.",{"name":155,"role":151,"phone":10,"phoneExt":10,"email":10},"Eric Duncavage, M.D.",{"name":157,"role":151,"phone":10,"phoneExt":10,"email":10},"Kelly Bolton, M.D., Ph.D.",{"type":159,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[161],{"name":162,"class":6},"Edward P. Evans Foundation","100255479",false,"NCT02604563","Aging, Geriatric Syndromes and Clonal Hematopoiesis","Inclusion Criteria:\n\n* At least 50 years of age.\n* Able to understand written and spoken English.\n* Able to understand and willing to sign an IRB-approved written informed consent document (or that of a legally authorized representative, if applicable for the trauma cohort)\n\nExclusion Criteria:\n\n* Inability or unwillingness to complete health questionnaire (with the exception of hip replacement participants).\n* History of a recent (\\\u003C30 days) acute viral illness.\n* Current cancer diagnosis and currently receiving chemotherapy or undergoing radiation therapy. A prior history of cancer is allowed if the participant completed therapy \\> 1 year prior to enrollment; participants with a prior diagnosis of cancer will be asked to sign a release of information for the research team to obtain records regarding their prior cancer treatment.\n* Current use of drugs that cause DNA damage (e.g. Cytoxan, azathioprine, etc.) for the treatment of a non-malignant disease.\n* Vulnerable populations (e.g. prisoners).\n* Known infection with Hepatitis B or C, HTLV, or HIV.\n* Additional exclusion for optional bone marrow aspirate\u002Fbiopsy substudy:\n\n  * Use of medications for anticoagulation or \"blood thinning\" including warfarin, low molecular weight heparins (enoxaparin, daltaparin) or direct-acting oral anticoagulants (dabigatran, rivaroxaban, apixaban, edoxaban or betrixaban)\n  * allergy to lidocaine or other local anesthetics.",true,"ALL","50 Years",{"count":172,"type":173},2000,"ESTIMATED","OBSERVATIONAL","In this study the investigators will incorporate a wide range of clinical variables associated with aging and cardiovascular disease to determine whether they are associated with mutation status independent of chronologic age. Clinically, aging can be operationalized using geriatric assessment, which entails a comprehensive multi-dimensional assessment of the health of an older adult, including measures of comorbidity, polypharmacy, functional status, cognition, depression, falls, social activities and social support. Given that aging is heterogeneous, geriatric assessment allows greater specificity for aging than chronological age alone.",[177,178,179,180],"Geriatrics","Aged","Geriatric Syndromes","Cardiovascular Diseases","2026-05-07",{"date":183,"type":184},"2026-05-12","ACTUAL",{"date":186,"type":184},"2016-03-10",{"date":188,"type":173},"2030-04-30",{"name":5,"class":6},1]