[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602355":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":32,"locations":42,"responsibleParty":61,"collaborators":10,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":10,"enrollmentInfo":72,"targetDuration":10,"studyType":75,"phases":10,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":45,"whyStopped":10,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Centre Hospitalier Universitaire de Saint Etienne","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Youngs",null,"Patients aged 18 to 30 requiring coronary artery bypass grafting (CABG).",[13],"Procedure: Graft collection",{"label":15,"type":10,"description":16,"interventionNames":17},"Middle-aged","Patients aged 30 to 60 requiring coronary artery bypass grafting (CABG).",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Elderly","Patients aged 60 and more requiring coronary artery bypass grafting (CABG).",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"PROCEDURE","Graft collection","Sampling of superior venous and arterial grafts (internal mammary artery, great saphenous vein) after coronary artery bypass surgery.",[19,15,9],[29],{"name":30,"affiliation":5,"role":31},"Salvatore CAMPISI, MD","PRINCIPAL_INVESTIGATOR",[33,39],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"Anne-Claire DUCHEZ, PhD","CONTACT","(0)477421423","+33","anne-claire.duchez@efs.sante.fr",{"name":30,"role":35,"phone":40,"phoneExt":37,"email":41},"(0)477829058","salvatore.campisi@chu-st-etienne.fr",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":47,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"CHU Saint-Etienne","RECRUITING","Saint-Etienne","France","42055","FR",{"type":51,"coordinates":52},"Point",[53,54],4.39,45.43389,{"lat":54,"lon":53},[57,58,60],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},{"name":34,"role":59,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"name":30,"role":31,"phone":10,"phoneExt":10,"email":10},{"type":62,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100602355","aging-of-the-vascular-wall-100602355",false,"NCT07122427","Aging of the Vascular Wall","VITAL","Inclusion Criteria:\n\n* Major patients requiring coronary artery bypass grafting (CABG).\n\nExclusion Criteria:\n\n* Hypertension, diabetes, systemic inflammatory disease.","ALL","18 Years",{"count":73,"type":74},30,"ESTIMATED","OBSERVATIONAL","Demographic aging is predicted to be one of the most significant social changes of the 21st century. Aging is a slow, multifactorial process that progressively impacts the integrity of cells, tissues, and organs. This decline in function increases the risk of numerous diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases (CVD). CVD, the leading global cause of death, becomes more prevalent with age. Aging contributes to endothelial dysfunction, vessel stiffness, thickening, and impaired platelet function. These changes disrupt hemostatic processes and increase the risk of cardiovascular complications. Despite preventive strategies CVD remain a major public health challenge. Cellular aging, or senescence, affects all cell types, particularly endothelial cells and platelets. However, little research has compared the aging rates of different blood vessel types, such as arteries and veins. Given their distinct compositions and developmental origins, it is likely that their aging processes differ at molecular, cellular, and physiological levels.",[78,79],"Vascular Risk","Aging Disorder",[81,82,83],"Cardiovascular diseases","Aging","Eendothelial dysfunction","2025-08-15",{"date":86,"type":87},"2025-08-20","ACTUAL",{"date":89,"type":87},"2025-07-17",{"date":91,"type":74},"2026-12",{"name":5,"class":6},1]