[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622342":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":39,"locations":48,"responsibleParty":175,"collaborators":177,"id":188,"slug":189,"hasResults":190,"nctId":191,"briefTitle":192,"officialTitle":193,"acronym":26,"eligibilityCriteria":194,"healthyVolunteers":190,"sex":195,"minAge":196,"maxAge":197,"enrollmentInfo":198,"targetDuration":26,"studyType":201,"phases":202,"briefSummary":204,"conditions":205,"keywords":207,"overallStatus":210,"whyStopped":26,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":218,"locationsCount":219},{"fullName":5,"class":6},"Nanjing Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Subtyping-based precision therapy","EXPERIMENTAL","* Balanced type (HIS1): No anti-inflammatory intervention required;\n\n  * Inflammation-excessive type (HIS2): Anti-inflammatory intervention with ulinastatin; ③ Immunosuppressive type (HIS3): Immunomodulation with thymalfasin; ④ Mixed reaction type (HIS4): Combined treatment with ulinastatin and thymalfasin.",[13],"Drug: Ulinastatin and Thymalfasin",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional Empirical Strategy","ACTIVE_COMPARATOR","treatment of physician's choice alone",[19],"Drug: Ulinastatin",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Ulinastatin and Thymalfasin","AI-assisted Immunoinflammatory Subtyping-guided Target-matching Individualized Anti-inflammatory Strategy",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Ulinastatin","Conventional empirical regimens will be formulated based on patients' clinical symptoms and routine inflammatory indicators (white blood cell count, C-reactive protein, procalcitonin) without uniform target-matching standards, with reference to clinical diagnosis and treatment guidelines: if obvious inflammatory responses are present (e.g., fever, significant elevation of C-reactive protein), non-steroidal anti-inflammatory drugs or low-dose glucocorticoids will be administered; if complicated with infection, combined antibiotic therapy will be given; for patients with normal or slightly elevated inflammatory indicators, anti-inflammatory drugs may be temporarily withheld, and close monitoring will be performed instead. The regimen will be adjusted according to changes in routine inflammatory indicators after surgery until the patient is discharged.",[15],[32,36],{"name":33,"affiliation":34,"role":35},"Yong-feng Shao","The First Affiliated Hospital with Nanjing Medical University","STUDY_DIRECTOR",{"name":37,"affiliation":34,"role":38},"Hong Liu","PRINCIPAL_INVESTIGATOR",[40,45],{"name":41,"role":42,"phone":43,"phoneExt":26,"email":44},"Sheng Zhao","CONTACT","18801281613","zhaosheng0824@njmu.edu.cn",{"name":46,"role":42,"phone":26,"phoneExt":26,"email":47},"Guo-laing Fan, MD","smartmanliang@sina.com",[49,68,83,100,115,131,147,160],{"facility":50,"status":26,"city":51,"state":26,"zip":26,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Beijing Anzhen Hospital","Beijing","China","CN",{"type":55,"coordinates":56},"Point",[57,58],116.39723,39.9075,{"lat":58,"lon":57},[61,64,66],{"name":62,"role":42,"phone":43,"phoneExt":26,"email":63},"Si-chong Qian, MD","drqsc1990a@163.com",{"name":65,"role":42,"phone":26,"phoneExt":26,"email":26},"Hai-yang Li",{"name":67,"role":38,"phone":26,"phoneExt":26,"email":26},"Hong-jia Zhang, MD",{"facility":69,"status":26,"city":70,"state":26,"zip":26,"country":52,"countryCode":53,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Changzhou First People Hospital","Changzhou",{"type":55,"coordinates":72},[73,74],119.95401,31.77359,{"lat":74,"lon":73},[77,81,82],{"name":78,"role":42,"phone":79,"phoneExt":26,"email":80},"Chao Ma, MD","15851983609","machaomain@163.com",{"name":78,"role":42,"phone":26,"phoneExt":26,"email":26},{"name":78,"role":38,"phone":26,"phoneExt":26,"email":26},{"facility":84,"status":26,"city":85,"state":26,"zip":26,"country":52,"countryCode":53,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"West China Hospital of Sichuan University","Chengdu",{"type":55,"coordinates":87},[88,89],104.06667,30.66667,{"lat":89,"lon":88},[92,96,98],{"name":93,"role":42,"phone":94,"phoneExt":26,"email":95},"Hong-hua YUE, MD","13281130798","yuecqmu@163.com",{"name":97,"role":42,"phone":26,"phoneExt":26,"email":26},"Zhong Wu, MD",{"name":99,"role":38,"phone":26,"phoneExt":26,"email":26},"Hong-hua Yue, MD",{"facility":101,"status":26,"city":102,"state":26,"zip":26,"country":52,"countryCode":53,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"Fujian Medical University Union Hospital","Fuzhou",{"type":55,"coordinates":104},[105,106],119.30611,26.06139,{"lat":106,"lon":105},[109,113,114],{"name":110,"role":42,"phone":111,"phoneExt":26,"email":112},"Dong-dong Wu, MD","17759515390","734223972@qq.com",{"name":110,"role":42,"phone":26,"phoneExt":26,"email":26},{"name":110,"role":38,"phone":26,"phoneExt":26,"email":26},{"facility":116,"status":26,"city":117,"state":26,"zip":26,"country":52,"countryCode":53,"cosmosGeoPoint":118,"geoPoint":122,"contacts":123},"The First Affiliated Hospital of Guangzhou Medical University","Guangzhou",{"type":55,"coordinates":119},[120,121],113.25,23.11667,{"lat":121,"lon":120},[124,127,129],{"name":125,"role":42,"phone":26,"phoneExt":26,"email":126},"Ying-yuan Zhang","13662378847@139.com",{"name":128,"role":42,"phone":26,"phoneExt":26,"email":26},"KAI WANG",{"name":130,"role":38,"phone":26,"phoneExt":26,"email":26},"Ying-yuan Zhang, MD",{"facility":132,"status":26,"city":133,"state":26,"zip":26,"country":52,"countryCode":53,"cosmosGeoPoint":134,"geoPoint":138,"contacts":139},"Nanchang University Second Hospital","Nanchang",{"type":55,"coordinates":135},[136,137],115.85306,28.68396,{"lat":137,"lon":136},[140,144,145],{"name":141,"role":42,"phone":142,"phoneExt":26,"email":143},"Ji-sheng Zhong, MD","13502153976","837966728@qq.com",{"name":141,"role":42,"phone":26,"phoneExt":26,"email":26},{"name":146,"role":38,"phone":26,"phoneExt":26,"email":26},"JI-SHENG Zhong, MD",{"facility":148,"status":26,"city":149,"state":26,"zip":26,"country":52,"countryCode":53,"cosmosGeoPoint":150,"geoPoint":154,"contacts":155},"The First Affiliated Hospital of Nanjing Medical University","Nanjing",{"type":55,"coordinates":151},[152,153],118.77778,32.06167,{"lat":153,"lon":152},[156,157,158],{"name":41,"role":42,"phone":43,"phoneExt":26,"email":44},{"name":33,"role":42,"phone":26,"phoneExt":26,"email":26},{"name":159,"role":38,"phone":26,"phoneExt":26,"email":26},"Hong Liu, MD",{"facility":161,"status":26,"city":162,"state":26,"zip":26,"country":52,"countryCode":53,"cosmosGeoPoint":163,"geoPoint":167,"contacts":168},"Shanghai East Hospital","Shanghai",{"type":55,"coordinates":164},[165,166],121.45806,31.22222,{"lat":166,"lon":165},[169,171,173],{"name":170,"role":42,"phone":26,"phoneExt":26,"email":47},"Guo-liang Fan",{"name":172,"role":42,"phone":26,"phoneExt":26,"email":26},"Hai-tao Zhang, MD",{"name":174,"role":38,"phone":26,"phoneExt":26,"email":26},"Guo-liang Fan, MD",{"type":38,"investigatorFullName":37,"investigatorTitle":176,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Principal Investigator of Department of Cardiovascular Surgery",[178,179,181,183,184,185,186],{"name":34,"class":6},{"name":180,"class":6},"The Third Affiliated Hospital of Soochow University",{"name":182,"class":6},"West China Hospital",{"name":101,"class":6},{"name":161,"class":6},{"name":50,"class":6},{"name":187,"class":6},"Second Affiliated Hospital of Nanchang University","100622342","ai-assisted-subtyping-directed-precision-treatment-in-acute-aortic-dissection-100622342",false,"NCT07382375","AI-assisted Subtyping-directed Precision Treatment in Acute Aortic Dissection","AI-assisted Immunoinflammatory Subtyping-Directed Precision Treatment in Acute Aortic Dissection: A Multicenter RCT-based Exploration","Inclusion Criteria:\n\n1. Confirmed diagnosis of acute aortic dissection by contrast-enhanced Computed Tomography Angiography (CTA) or Magnetic Resonance Angiography (MRA);\n2. Planned emergency surgical treatment (including open surgery and endovascular repair);\n3. Aged 18-80 years old, regardless of gender;\n4. Time from onset to hospital admission ≤ 72 hours;\n5. Signed informed consent form by the patient or their authorized agent, with willingness to cooperate with the follow-up of the study.\n\nExclusion Criteria:\n\n1. Complicated with underlying diseases that affect immunoinflammatory status, such as severe infections (e.g., sepsis, infective endocarditis), autoimmune diseases, malignant tumors, chronic liver diseases, and chronic kidney diseases (uremic stage);\n2. Long-term use of immunosuppressants or glucocorticoids before surgery (continuous use for ≥ 2 weeks);\n3. Pregnant or lactating women;\n4. Patients with mental disorders or cognitive dysfunction who cannot cooperate with the study.","ALL","18 Years","80 Years",{"count":199,"type":200},300,"ESTIMATED","INTERVENTIONAL",[203],"NA","Aortic dissection has acute onset and high mortality, with immunoinflammatory response driving lesion progression. Current perioperative anti-inflammatory therapies are mostly empirical and poorly targeted, and AI-assisted typing lacks a complete clinical translation pathway. This study integrates multi-dimensional data to construct an AI immunoinflammatory subtyping system, enabling rapid subtyping and establishing a \"subtyping-target-treatment\" closed loop for emergency needs. Using a prospective multicenter RCT, 300 patients are randomly divided into two groups: the experimental group receives subtyping-based precision therapy, while the control group uses empirical strategies (treatment of physician's choice). It observes 7-day postoperative SOFA score, SIRS and other prognostic indicators to provide evidence-based support for precision treatment.",[206],"Aortic Aneurysm and Dissection",[208,209],"inflammation","immune","NOT_YET_RECRUITING","2026-01-28",{"date":213,"type":214},"2026-02-02","ACTUAL",{"date":216,"type":200},"2027-12-31",{"date":216,"type":200},{"name":5,"class":6},8]