[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574920":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":27,"centralContacts":32,"locations":41,"responsibleParty":62,"collaborators":65,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":10,"enrollmentInfo":79,"targetDuration":10,"studyType":82,"phases":10,"briefSummary":83,"conditions":84,"keywords":88,"overallStatus":43,"whyStopped":10,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Jena University Hospital","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with ICUAW (ICUAW+)",null,"Critically ill patients with ICUAW.",[13],"Diagnostic Test: Neuromuscular Ultrasound",{"label":15,"type":10,"description":16,"interventionNames":17},"Patients without ICUAW (ICUAW-)","Critically ill patients without ICUAW.",[13],{"label":19,"type":10,"description":10,"interventionNames":20},"Healthy controls without ICUAW (ICUAW-)",[13],[22],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"DIAGNOSTIC_TEST","Neuromuscular Ultrasound","Non-invasive ultrasound of peripheral muscles of the upper and lower extremities with additional artificiall intelligence processing of ultrasound images.",[19,9,15],[28],{"name":29,"affiliation":30,"role":31},"PD Dr. Johannes Ehler, M.D.","Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital","PRINCIPAL_INVESTIGATOR",[33,37],{"name":29,"role":34,"phone":35,"phoneExt":10,"email":36},"CONTACT","+4936419323397","johannes.ehler@med.uni-jena.de",{"name":38,"role":34,"phone":39,"phoneExt":10,"email":40},"Dr. Konstantin Schubert, M.D.","+4936419323371","konstantin.schubert@med.uni-jena.de",[42],{"facility":30,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Jena","Thuringia","07747","Germany","DE",{"type":50,"coordinates":51},"Point",[52,53],11.5899,50.92878,{"lat":53,"lon":52},[56,58,60],{"name":57,"role":34,"phone":35,"phoneExt":10,"email":36},"Johannes Ehler, PD Dr. med.",{"name":59,"role":34,"phone":39,"phoneExt":10,"email":40},"Konstantin Schubert, Dr.",{"name":61,"role":34,"phone":10,"phoneExt":10,"email":10},"Johannes Ehler, PD Dr.",{"type":31,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Johannes Ehler","Principal Investigator",[66],{"name":67,"class":6},"University of Rostock","100574920","ai-based-muscular-ultrasound-to-assess-intensive-care-unit-acquired-weakness-100574920",false,"NCT06765551","AI Based Muscular Ultrasound to Assess Intensive Care Unit-acquired Weakness","Artificial IntelligenCe Based UlTrasonographic Assessment of IntensiVe CAre UniT-acquired WEakness (ACTIVATE)","ACTIVATE","Inclusion Criteria:\n\n* Patients aged 18 years or above\n* Major elective surgery, e.g. cardiothoracic or abdominal surgery\n* Expected ICU stay \\>1 day postoperatively\n* Healthy, age-machted subjects without ICUAW (recruited from staff of the department of anesthesiology and intensive care medicine)\n\nExclusion Criteria:\n\n* No informed consent\n* Emergency surgery\n* Previous participation in the same study\n* Preexisting neuromuscular disease\n* Preexisting central nervous system disease with residual neuromuscular impairment (e.g. cerebral haemorrhage, stroke, brain tumor)\n* High-dose glucocorticoid therapy (\\>300 mg hydrocortisone or equivalent per day) before or during particiation in the study",true,"ALL","18 Years",{"count":80,"type":81},50,"ESTIMATED","OBSERVATIONAL","The aim of this observational case-control study is to investigate, whether artificial intelligence can detect ultrasound-derived imaging characteristics typical for intensive care unit-acquired weakness. The main questions it aims to answer are:\n\n1. Is the evaluation of specific parameters of neuromuscular ultrasound using AI-based image analysis suitable for detecting and monitoring critically ill ICU patients with ICUAW?\n2. Do the results of AI-based ultrasound image analysis correlate with:\n\n(A) the severity of ICUAW (B) the visual grading of muscle echogenicity (C) the 30- and 90-day-outcome?",[85,86,87],"Intensive Care Unit-acquired Weakness","Artifical Intelligence","Ultrasound",[89,90,91,92,93],"weakness","neuromuscular","critical illness polyneuropathy","critical illness myopathy","neuromuscular impairment","2025-01-03",{"date":96,"type":97},"2025-01-09","ACTUAL",{"date":99,"type":97},"2024-10-01",{"date":101,"type":81},"2026-06-30",{"name":5,"class":6},1]