[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616277":3},{"organization":4,"armGroups":7,"interventions":37,"overallOfficials":55,"centralContacts":59,"locations":65,"responsibleParty":80,"collaborators":10,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":91,"minAge":92,"maxAge":10,"enrollmentInfo":93,"targetDuration":10,"studyType":96,"phases":10,"briefSummary":97,"conditions":98,"keywords":103,"overallStatus":68,"whyStopped":10,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"University of California, Los Angeles","OTHER",[8,14,19,24,29,33],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1-Adult participants - Arm A",null,"Will review the original ICF",[13],"Behavioral: Original ICF",{"label":15,"type":10,"description":16,"interventionNames":17},"Group 1 - Adult participants - Arm B","Will review the simplified ICF",[18],"Behavioral: AI Simplified ICF",{"label":20,"type":10,"description":21,"interventionNames":22},"Group 1- Adult participants - Arm C","Will listen to a podcast in conjunction to the original ICF",[13,23],"Behavioral: Podcast - Original ICF",{"label":25,"type":10,"description":26,"interventionNames":27},"Group 1-Adult participants - Arm D","Will listen to a podcast in conjunction to the simplified ICF",[18,28],"Behavioral: Podcast - Simplified ICF",{"label":30,"type":10,"description":31,"interventionNames":32},"Group 2 - Investigators","PIs who are health providers that perform clinical trials",[13,18,23],{"label":34,"type":10,"description":35,"interventionNames":36},"Group 3 - IRB individuals","Individuals involved in IRB activities (chairs, committee members, staff)",[13,18,23],[38,43,47,51],{"type":39,"name":40,"description":41,"armGroupLabels":42,"otherNames":10},"BEHAVIORAL","Original ICF","Participant will review the original ICF",[20,9,30,34],{"type":39,"name":44,"description":45,"armGroupLabels":46,"otherNames":10},"AI Simplified ICF","Participant will review the AI Simplified ICF",[15,25,30,34],{"type":39,"name":48,"description":49,"armGroupLabels":50,"otherNames":10},"Podcast - Original ICF","Listen to a podcast that is developed to provide an engaging format for the original ICF.",[20,30,34],{"type":39,"name":52,"description":53,"armGroupLabels":54,"otherNames":10},"Podcast - Simplified ICF","Listen to a podcast that is developed to provide an engaging format for the simplified ICF.",[25],[56],{"name":57,"affiliation":5,"role":58},"Arash Naeim, MD, PhD","PRINCIPAL_INVESTIGATOR",[60],{"name":61,"role":62,"phone":63,"phoneExt":10,"email":64},"Erinn Knox","CONTACT","(310) 490-4888","eknox@mednet.ucla.edu",[66],{"facility":67,"status":68,"city":69,"state":70,"zip":71,"country":72,"countryCode":73,"cosmosGeoPoint":74,"geoPoint":79,"contacts":10},"UCLA","RECRUITING","Los Angeles","California","90095","United States","US",{"type":75,"coordinates":76},"Point",[77,78],-118.24368,34.05223,{"lat":78,"lon":77},{"type":81,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100616277","ai-driven-consent-simplification-study-100616277",false,"NCT07303517","AI-Driven Consent Simplification Study","ACCESS: AI-Driven Consent Simplification Study","ACCESS","Inclusion Criteria:\n\nGroup 1:\n\n* Age 60 years and above\n* UCLA patient\n* English speaking\n* Ability to provide informed consent\n\nGroup 2:\n\n* UCLA investigators who are health providers that perform clinical trials\n* Must be clinical research investigatory and staff actively involved in research operations at UCLA\n* English speaking\n\nGroup 3:\n\n* Individuals involved in IRB activities (chairs, committee members, staff)\n* Must be a director or staff at UCLA\n* English speaking\n\nExclusion Criteria:\n\n* Group 1: None\n* Group 2: PI and co-PIs of the study \"Donor Chimerism and Graft Survival Following Combined HLA-Identical Sibling Living Donor Kidney and Hematopoietic Stem Cell Transplantation Utilizing a Conditioning Regimen of Total Lymphoid Irradiation (TLI) and Rabbit Anti-Thymocyte Globulin (rATG)\"\n* Group 3: Individuals from the IRB who have reviewed the study submission for \"Donor Chimerism and Graft Survival Following Combined HLA-Identical Sibling Living Donor Kidney and Hematopoietic Stem Cell Transplantation Utilizing a Conditioning Regimen of Total Lymphoid Irradiation (TLI) and Rabbit Anti-Thymocyte Globulin (rATG)\"",true,"ALL","18 Years",{"count":94,"type":95},230,"ESTIMATED","OBSERVATIONAL","The overarching goal of this pilot is to explore how generative artificial intelligence (genAI) can be used to improve the accessibility and understandability of informed consent materials in clinical research. The study will test the extent to which informed consent text can be improved by large language models (LLM; specifically, ChatGPT and NotebookLM) along with other AI tools (specifically, ElevenLabs) through qualitative and quantitative analyses.\n\nSimplifying such forms using genAI may facilitate better comprehension, ensuring truly informed consent. Improving informed consent form (ICF) comprehension can lead to more informed and willing participation in clinical studies. This improved understanding may result in higher enrollment rates, better subject retention, and more accurate data collection as individuals will have a clearer understanding of study procedures and risks.",[99,100,101,102],"Informed Consent","Comprehension","Communication","Disclosure",[104,105,106,107],"Informed Consent Readability","Plain language","Simplified consent forms","Research ethics","2026-05-04",{"date":110,"type":111},"2026-05-08","ACTUAL",{"date":113,"type":111},"2026-01-08",{"date":115,"type":95},"2026-12-01",{"name":5,"class":6},1]