[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637545":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":24,"centralContacts":29,"locations":24,"responsibleParty":35,"collaborators":39,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":24,"enrollmentInfo":68,"targetDuration":24,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":79,"overallStatus":88,"whyStopped":24,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":24},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Usual Postoperative Follow-up Strategy","ACTIVE_COMPARATOR","Participants will receive the existing postoperative follow-up pathway at each center after ATAAD repair, including routine discharge education, blood pressure and medication management, outpatient or telephone follow-up, CTA or ultrasound follow-up according to center practice, and management of abnormal findings through routine clinical pathways. AI risk stratification reports will not be provided to the clinical team in this arm, except for ethically required safety information if applicable.",[13],"Other: Usual Postoperative Follow-up Strategy",{"label":15,"type":16,"description":17,"interventionNames":18},"AI Prediction Model-Guided Intensified Follow-up Strategy.","EXPERIMENTAL","Participants will receive usual postoperative follow-up plus AI-generated risk stratification for 1-year mortality and adverse aortic remodeling. The risk report will classify participants as low, moderate, high, or very high risk. Higher-risk participants may receive more frequent follow-up, earlier or prioritized CTA review, active telephone tracking, multidisciplinary team discussion, rapid review of abnormal imaging findings, and reintervention risk assessment. The AI report is auxiliary and does not replace physician judgment.",[19],"Other: AI Prediction Model-Guided Intensified Follow-up Strategy",[21,25],{"type":6,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"Routine postoperative surveillance and management after acute type A aortic dissection repair according to each center's standard clinical practice.",[9],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"AI Prediction Model-Guided Intensified Follow-up Strategy","Use of a previously developed AI multimodal prediction model to generate risk stratification for postoperative 1-year mortality and adverse aortic remodeling, triggering protocolized intensified follow-up actions when indicated.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"Cai Cheng, MD, PhD","CONTACT","+8618857163588","cai.cheng@hotmail.com",{"type":36,"investigatorFullName":37,"investigatorTitle":38,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Cheng Cai","Principal Investigator",[40,42,44,46,48,50,52,54,56],{"name":41,"class":6},"The Affiliated Hospital of Qingdao University",{"name":43,"class":6},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School",{"name":45,"class":6},"Guangdong Provincial People's Hospital",{"name":47,"class":6},"Sir Run Run Shaw Hospital",{"name":49,"class":6},"Wuhan Asia Heart Hospital",{"name":51,"class":6},"Tongji Hospital",{"name":53,"class":6},"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology",{"name":55,"class":6},"Renmin Hospital of Wuhan University",{"name":57,"class":6},"Beijing Anzhen Hospital","100637545","ai-guided-intensified-follow-up-after-surgery-for-acute-type-a-aortic-dissection-100637545",false,"NCT07623213","AI-Guided Intensified Follow-up After Surgery for Acute Type A Aortic Dissection","Artificial Intelligence Multimodal Prediction Model-Guided Intensified Follow-up Strategy for 1-Year Outcomes After Surgery for Acute Type A Aortic Dissection: A Multicenter Randomized Controlled Trial","AIMS-ATAAD-FU","Inclusion Criteria:\n\n* 1\\. Age 18 years or older. 2. Acute Stanford type A aortic dissection confirmed by CTA, intraoperative findings, or medical records.\n\n  3\\. Underwent open surgical repair or open repair combined with endovascular\u002Fhybrid repair.\n\n  4\\. Postoperative condition is stable and the patient is planned for discharge or has entered early post-discharge follow-up.\n\n  5\\. Core baseline data required for AI model operation are available, including at least one eligible preoperative or postoperative CTA imaging dataset.\n\n  6\\. Able to complete telephone, outpatient, or inpatient follow-up and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* 1\\. Predominantly chronic type A dissection, traumatic dissection, or iatrogenic dissection, if the investigator judges the patient unsuitable for this follow-up strategy study.\n\n  2\\. Did not undergo surgical repair, received only palliative treatment, or did not meet postoperative randomization conditions.\n\n  3\\. Expected inability to complete 12-month follow-up, no stable contact information, or inability to obtain outpatient, telephone, or inpatient follow-up data.\n\n  4\\. Severe missing baseline data preventing generation of the AI risk report. 5. Concurrent participation in another interventional study that may substantially affect postoperative follow-up intensity or the primary outcome.\n\n  6\\. Any other condition that, in the investigator's judgment, makes the patient unsuitable for participation.","ALL","18 Years",{"count":69,"type":70},1314,"ESTIMATED","INTERVENTIONAL",[73],"NA","This multicenter, prospective, randomized controlled trial will evaluate whether an artificial intelligence (AI) multimodal prediction model-guided intensified follow-up strategy improves 1-year outcomes after surgery for acute Stanford type A aortic dissection. Eligible adult patients who have undergone open surgical repair or open plus endovascular\u002Fhybrid repair and are clinically stable to enter the postoperative follow-up phase will be randomized 1:1 to usual postoperative follow-up or AI-guided intensified follow-up. The AI-guided arm will receive usual follow-up plus an AI-generated risk stratification report for 1-year mortality and adverse aortic remodeling. Higher-risk patients may receive more frequent follow-up, prioritized CTA review, multidisciplinary assessment, and targeted management reminders. The primary outcome is all-cause mortality through postoperative day 365. Key secondary outcomes include aortic reintervention, adverse aortic remodeling, and ICU readmission within 1 year.",[76,77,78],"Acute Type A Aortic Dissection","Stanford Type A Aortic Dissection","Postoperative Aortic Dissection Follow-up",[80,81,82,83,84,85,86,87],"Acute type A aortic dissection","ATAAD","randomized controlled trial","artificial intelligence","multimodal prediction model","intensified follow-up","aortic reintervention","adverse aortic remodeling","NOT_YET_RECRUITING","2026-05-29",{"date":91,"type":92},"2026-06-03","ACTUAL",{"date":94,"type":70},"2026-12-01",{"date":96,"type":70},"2029-12-01",{"name":5,"class":6}]