[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627707":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":49,"collaborators":26,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":26,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":77,"whyStopped":26,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Singapore General Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Conventional stimulation","ACTIVE_COMPARATOR","Conventional single-electrode continuous transcutaneous spinal cord stimulation (static tSCS)",[13],"Device: Static stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Multielectrode dynamic stimulation","EXPERIMENTAL","Continuous midline stimulation with concurrent lateral electrode activation targeting the relevant nerve root during voluntary movement attempts (dynamic tSCS)",[19],"Device: Dynamic stimulation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Dynamic stimulation","Multielectrode transcutaneous spinal cord stimulation with real-time spatiotemporal modulation",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Static stimulation","tSCS delivered via a single midline electrode positioned over the thoracolumbar region (T11-T12). Stimulation is delivered in a continuous mode",[9],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Jing Chen, MD","CONTACT","+6565762049","chen.jing@singhealth.com.sg",[38],{"facility":5,"status":26,"city":39,"state":26,"zip":26,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Singapore","SG",{"type":42,"coordinates":43},"Point",[44,45],103.85007,1.28967,{"lat":45,"lon":44},[48],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"type":50,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100627707","ai-powered-closed-loop-multielectrode-transcutaneous-spinal-cord-stimulation-real-time-adjustments-for-enhanced-motor-recovery-in-spinal-cord-injury-aim-recover-100627707",false,"NCT07452133","AI-Powered Closed-Loop Multielectrode Transcutaneous Spinal Cord Stimulation: Real-Time Adjustments for Enhanced Motor Recovery in Spinal Cord Injury (AIM RECOVER)","AIM RECOVER","Inclusion Criteria:\n\nHealthy volunteers:\n\n1. Adults aged 21 years or older with the mental capacity to provide informed consent.\n2. No prior diagnosis of neuromuscular or neurological conditions affecting the lower limbs.\n3. Able to walk independently with a normal gait pattern, as confirmed by clinical observation done by the study team.\n\nSCI patients:\n\n1. Age 21 -75 years;\n2. Non-progressive, incomplete SCI (traumatic or non-traumatic).\n3. International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) \u002FASIA Impairment scale (AIS) grade B, C, or D, with Lower Extremity Motor Scores (ISNCSCI-LEMS) less than or equal to 40;\n4. Injury level at\u002Fabove L1 (above conus medullaris) with intact segmental reflexes below level of lesion;\n5. Able to provide informed consent;\n6. No contraindication for tSCS, such as pace makers or other implantable electrical devices;\n7. Eligible for body-weight support treadmill training;\n8. Able to stand with body weight support and\u002For assistance.\n\nExclusion Criteria:\n\nHealthy voluteers:\n\n1. Presence of significant or unstable medical comorbidities, including uncontrolled cardiopulmonary disease or severe cognitive impairment, as determined by the study team.\n2. Diagnosis of any neuromuscular or musculoskeletal disorders (e.g., congenital skeletal deformity, limb amputation, neurological disorders, myopathy).\n3. Abnormal gait pattern due to underlying medical co-morbidities, as identified through physical examination and clinical assessment, and confirmed by the study team.\n4. Current pregnancy.\n\nSCI patients:\n\n1. Significant or unstable medical co-morbidities, including uncontrolled cardiopulmonary disease, severe cognitive impairment, or severe dysautonomia, as determined by the study team;\n2. Uncontrolled neuropathic or musculoskeletal pain, or contractures affecting participation in therapy;\n3. Known history of peripheral nerve injury (e.g., traumatic nerve injury, entrapment neuropathy);\n4. Pregnancy;\n5. Active malignancy or ongoing cancer treatment;\n6. Skin conditions (e.g., ulcers, infections, malignant lesions) that limit the application of tSCS electrodes;\n7. Prior exposure to tSCS or eSCS interventions.",true,"ALL","21 Years","75 Years",{"count":63,"type":64},7,"ESTIMATED","INTERVENTIONAL",[67],"NA","Spinal cord injury (SCI) often results in persistent motor deficits that are inadequately addressed by conventional rehabilitation. Transcutaneous spinal cord stimulation (tSCS) is a promising non-invasive neuromodulatory approach that can enhance motor activation and gait performance; however, current tSCS systems rely on static, pre-programmed stimulation parameters that do not adapt to real-time motor output or task demands. This limitation may reduce muscle selectivity and disrupt the spatiotemporal dynamics of spinal network activation required for functional movement.\n\nThis study aims to develop and evaluate an AI-powered closed-loop multielectrode tSCS system that dynamically adjusts stimulation parameters in real time based on kinematic and surface electromyography (EMG) feedback during walking in individuals with incomplete SCI. The study will compare immediate muscle recruitment and motor performance between conventional static tSCS and dynamic, targeted tSCS guided by real-time physiological signals.\n\nThe investigators hypothesize that AI-driven closed-loop tSCS will be safe and feasible, and will result in superior muscle activation patterns and improved gait performance compared with static stimulation. Findings from this study will provide foundational evidence for adaptive neuromodulation strategies and support the advancement of next-generation, data-driven spinal cord stimulation technologies for neurorehabilitation in SCI.",[70],"Spinal Cord Injury",[70,72,73,74,75,76],"Transcutaneous Spinal Cord Stimulation (tSCS)","Closed-Loop Neuromodulation","Artificial Intelligence","Wearable Sensors","Neurorehabilitation","NOT_YET_RECRUITING","2026-03-01",{"date":80,"type":81},"2026-03-05","ACTUAL",{"date":83,"type":64},"2026-05",{"date":85,"type":64},"2028-09",{"name":5,"class":6},1]