[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618219":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":32,"locations":41,"responsibleParty":63,"collaborators":11,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":11,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":11,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":11,"overallStatus":87,"whyStopped":11,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"QiLin-assisted physician arm","EXPERIMENTAL",null,[13],"Other: QiLin-assisted",{"label":15,"type":16,"description":11,"interventionNames":17},"physician only arm","ACTIVE_COMPARATOR",[18],"Other: physician only, without QiLin assisted",[20,24],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"QiLin-assisted","A Comprehensive Deep Learning Model for Assisting the decision of anti-VEGF therapy: QiLin system",[9],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":11},"physician only, without QiLin assisted","without QiLin assisted",[15],[29],{"name":30,"affiliation":5,"role":31},"Xiaodong Sun, PhD","PRINCIPAL_INVESTIGATOR",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":11,"email":37},"Xiaodong Prof. Sun, PhD","CONTACT","86 17853138155","xdsun@sjtu.edu.cn",{"name":39,"role":35,"phone":36,"phoneExt":11,"email":40},"Huixun Jia, PhD","jiahuixun@sjtu.edu.cn",[42,56],{"facility":43,"status":11,"city":44,"state":11,"zip":11,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Shanghai general hospital, Shanghai Jiao Tong University, Shanghai, 200080","Shanghai","China","CN",{"type":48,"coordinates":49},"Point",[50,51],121.45806,31.22222,{"lat":51,"lon":50},[54],{"name":30,"role":35,"phone":55,"phoneExt":11,"email":37},"+86-02163240090",{"facility":57,"status":11,"city":44,"state":11,"zip":11,"country":45,"countryCode":46,"cosmosGeoPoint":58,"geoPoint":60,"contacts":61},"Shanghai general hospital",{"type":48,"coordinates":59},[50,51],{"lat":51,"lon":50},[62],{"name":39,"role":35,"phone":36,"phoneExt":11,"email":40},{"type":31,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Xiaodong Sun","Professor","100618219","ai-vs-physician-for-anti-vegf-decision-making-an-rct-100618219",false,"NCT07328776","AI vs. Physician for Anti-VEGF Decision-Making: An RCT","An Artificial Intelligence System for Anti-VEGF Treatment Decisions in Retinal Diseases: A Randomized Controlled Trial","Inclusion Criteria:\n\nPatients with a diagnosis of nAMD, DME, and RVO; Patients who have completed the loading-dose treatment of anti-VEGF agents; Patients who were willing to participate and provided written informed consent.\n\nExclusion Criteria:\n\nRefusal to undergo OCT testing; Refusal to complete the 3-month follow-up period; Screening for a history of intraocular surgery within the past 6 months; Subjects with severe systemic diseases, intellectual developmental disorders, psychiatric illnesses, etc.","ALL","50 Years","85 Years",{"count":77,"type":78},200,"ESTIMATED","INTERVENTIONAL",[81],"NA","We developed an artificial intelligence system, called QiLin, which was designed to assist anti-VEGF treatment decisions in retinal diseases. QiLin was trained and validated via over 20,000 optical coherence tomography images from multicenter datasets, demonstrating strong performance on both internal and external validation. To evaluate its real-world clinical utility, we conducted a randomized controlled trial that rigorously compares the accuracy of treatment decisions between a physician-only arm and an AI-assisted physician arm.",[84,85,86],"DME","Retinal Vein Occlusion (RVO)","Neovascular (Wet) Age-Related Macular Degeneration","NOT_YET_RECRUITING","2026-05-18",{"date":90,"type":91},"2026-05-22","ACTUAL",{"date":93,"type":78},"2026-05-25",{"date":95,"type":78},"2026-10-15",{"name":5,"class":6},2]