[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100504924":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":31,"responsibleParty":47,"collaborators":19,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":51,"sex":57,"minAge":58,"maxAge":19,"enrollmentInfo":59,"targetDuration":19,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":19,"overallStatus":33,"whyStopped":19,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Centre hospitalier de l'Université de Montréal (CHUM)","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Air Leaks","EXPERIMENTAL","Lungs from patients undergoing lung transplantation after their removal from the recipient patient with previous informed consent signed before transplantation will be obtained. The organs will be placed in an acrylic box and will be kept at a temperature of 37 Celsius degrees. In order to reproduce intraoperative air leaks, various manipulations, including stapling and creating lacerations of different depts and lengths on the parenchyma, will be performed on deflated lungs. Following the introduction of a leak, condensed gas will be pushed through the airway to precisely localize the defect. The sealant prepared at room temperature will then be applied in a thin layer to cover the defect and will be left to dry for 5 minutes. The seal will be tested using the condensed gas with the lung still deflated as well as with the water immersion technique after inflating the lung.",[13],"Diagnostic Test: Air Leaks",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DIAGNOSTIC_TEST","The organs will be placed in an acrylic box and will be kept at a temperature of 37 Celsius degrees. The lungs will be mechanically ventilated connected by an endotracheal tube size 8 inserted in the bronchus with the balloon inflated and a silk suture providing an hermetic closure proximal to the balloon.\n\nThis setting will allow us to perform several different endoscopic and RAB procedures in emulated physiologic conditions to complete the study.",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Moishe Liberman, MD","CHUM","PRINCIPAL_INVESTIGATOR",[26],{"name":22,"role":27,"phone":28,"phoneExt":29,"email":30},"CONTACT","514-890-8000","26832","moishe.liberman@umontreal.ca",[32],{"facility":23,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"RECRUITING","Montreal","Quebec","H2X 0A9","Canada","CA",{"type":40,"coordinates":41},"Point",[42,43],-73.58781,45.50884,{"lat":43,"lon":42},[46],{"name":22,"role":27,"phone":28,"phoneExt":29,"email":30},{"type":48,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100504924","air-leak-detection-and-treatment-100504924",false,"NCT05854654","Air Leak Detection and Treatment","Defining Novel Strategies for the Diagnosis and Treatment of Intraoperative Air Leaks: An Ex-Vivo Human Lung Model Study","CT0128","Inclusion Criteria:\n\n* Patients undergoing lung transplant surgery\n* Organ donor ineligible to donate lungs\n\nExclusion Criteria:\n\n* Healthy individuals","ALL","18 Years",{"count":60,"type":61},200,"ESTIMATED","INTERVENTIONAL",[64],"NA","Developing a methodology to detect, quantify and treat air leaks intraoperatively using a bio-adhesive, to thereby reduce postoperative surgical complications, morbidity, and length of stay for patients undergoing pulmonary resection.",[67],"Air Leak From Lung","2026-03-17",{"date":70,"type":71},"2026-03-18","ACTUAL",{"date":73,"type":71},"2023-05-02",{"date":75,"type":61},"2027-04-01",{"name":5,"class":6},1]