[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100508709":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":40,"responsibleParty":60,"collaborators":62,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":26,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Weill Cornell Medical College in Qatar","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active mode","ACTIVE_COMPARATOR","In home use of portable air cleaners with a High Efficiency Particulate Air (HEPA) filter for 4 weeks.",[13],"Device: Air cleaners with HEPA filter",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham mode","SHAM_COMPARATOR","In home use of portable air cleaners without a High Efficiency Particulate Air (HEPA) filter for 4 weeks.",[19],"Device: Air cleaners without HEPA filter",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Air cleaners with HEPA filter","PM 2.5 exposure reduction using in home portable air cleaners fitted with HEPA filters",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Air cleaners without HEPA filter","Simulation of PM 2.5 exposure reduction using in home portable air cleaners without HEPA filters.",[15],[32],{"name":33,"affiliation":5,"role":34},"Charbel Abi Khalil, MD","PRINCIPAL_INVESTIGATOR",[36],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","+974 4492 8484","cha2022@qatar-med.cornell.edu",[41],{"facility":42,"status":43,"city":44,"state":26,"zip":26,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Hamad Medical Corporation","RECRUITING","Doha","Qatar","QA",{"type":48,"coordinates":49},"Point",[50,51],51.53096,25.28545,{"lat":51,"lon":50},[54,58],{"name":55,"role":37,"phone":56,"phoneExt":26,"email":57},"Jassim Al-Suwaidi, MD","+974 4439 5354","jalsuwaidi@hamad.qa",{"name":59,"role":34,"phone":26,"phoneExt":26,"email":26},"Charbel Abi Khalil, MD, PhD",{"type":61,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[63,65],{"name":42,"class":64},"INDUSTRY",{"name":66,"class":6},"Case Western Reserve University","100508709","air-pollution-and-cardiovascular-disease-in-qatar-an-interventional-study-to-reduce-blood-pressure-100508709",false,"NCT05903950","Air Pollution and Cardiovascular Disease in Qatar: an Interventional Study to Reduce Blood Pressure","Air Pollution and Cardiovascular Disease in Qatar: an Interventional Study to Reduce Blood Pressure: the APCIQ-BP Trial","APCIQ-BP","Inclusion Criteria:\n\n* Non-smokers (100% abstinence from use of any smoking or vaping product during the prior year)\n* Age ≥18 and less than 60 years old\n* Living in a single residence (home, apartment) located anywhere in Qatar\n* Mild systolic hypertension: screening visit systolic BP 130 to 159 mm Hg (off treatment or taking ≤ 2 BP medications that have been stable without changes during prior 4 weeks) plus ≥ 2 more additional criteria for the metabolic syndrome:\n\n  * Waist circumference ≥102 cm if male and ≥88 cm if female\n  * Fasting triglycerides ≥150 mg\u002FdL (or taking a triglyceride-lowering medication)\n  * HDL-C ≤ 40 mg\u002FdL if male and ≤ 50 mg\u002FdL if female (or taking an HDL-raising medication),\n  * Fasting glucose ≥100 mg\u002FdL\n\nExclusion Criteria:\n\n* Pregnancy (self-reported)\n* Screening visit urine positive for cotinine (NicAlert \\>100 ng\u002FmL)\n* Living with an active smoker who smokes indoors (by self-report)\n* High risk conditions that prohibit allowing home BP to be \\>130\u002F80 mm Hg during the10-week trial including any cardiovascular disease (coronary artery disease, prior stroke, heart failure, peripheral arterial disease, aneurysm) or ≥ stage 3 kidney disease (estimated glomerular filtration rate \\\u003C 60 ml\u002Fmin)\n* A medical condition placing the participant at risk from participation (per investigators)\n* Expected overnight travel outside their residence during the study\n* HEPA filter within the air conditioners of the residence (self-reported) or individual use of HEPA filter\n* Unable to comprehend\u002Fsign an informed consent\n* Lung disease requiring oxygen\n* Cancer receiving treatment\n* Screening visit: BP ≥160\u002F100 mm Hg or fasting blood glucose ≥126 mg\u002FdL and confirmed diabetes with follow-up HbA1c ≥6.5%. If glucose is elevated ≥126 mg\u002FdL but HbA1c\\\u003C6.5%, they could still participate.\n* Medication changes in past 4 weeks. If participants are on medications for high BP or hyperlipidemia, they will need to have had stable therapy during prior 10 weeks with no planned changes during the study\n* Left upper arm circumference \\>17 inches as this will make BP levels inaccurate with the home monitor used\n* Acute illness or infectious symptoms within the prior 4 weeks.","ALL","18 Years","60 Years",{"count":79,"type":80},100,"ESTIMATED","INTERVENTIONAL",[83],"NA","The main objective is to determine if in-home portable air cleaners provide persistent reductions in PM2.5 exposures and improvements in systolic blood pressure and biochemical parameters over 4-weeks in patients with metabolic syndrome residing in Qatar.",[86,87],"Hypertension, Systolic","Metabolic Syndrome",[89,90,91],"hypertension","metabolic syndrome","air pollution","2025-07-16",{"date":94,"type":95},"2025-07-20","ACTUAL",{"date":97,"type":95},"2024-11-03",{"date":99,"type":80},"2026-04",{"name":5,"class":6},1]