[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641691":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":26,"locations":36,"responsibleParty":62,"collaborators":25,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":66,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":25,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":25,"overallStatus":39,"whyStopped":25,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Hospital Ambroise Paré Paris","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active rTMS of followed by active aiTBS or conversely","EXPERIMENTAL","Both the interventions target the motor cortex representing the first dorsal interosseus muscle (FDI) and the stimulation is delivered at 80% of resting motor threshold (RMT).\n\nActive rTMS consists of 5 stimulation sessions distributed over 5 consecutive days. Each session (25 to 30 minutes) consists of 15 series of 10-s pulses with a frequency of 10 Hz and an inter-train interval of 50s, for a total of 1500 pulses per session.\n\nActive aiTBS consists of 5 stimulation sessions given in a single day with an intersession interval of 45 minutes and a 110-minute break between the third and the fourth session. One session is composed of 50 cycles. Each cycle consists of 2 s of train stimulation and 8 s of pause. Each train consists of 10 bursts at 5 Hz, and each burst consists of 3 pulses at 50 Hz.\n\nIn both interventions a total of 7500 pulses are delivered. The order of the two interventions will be decided by randomization and there will be a wash-out period of 4 to 6 weeks in between",[13],"Device: Active rTMS, active aiTBS, sham rTMS or sham aiTBS",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham rTMS followed by sham aiTBS or conversely","SHAM_COMPARATOR","Sham rTMS followed by sham aiTBS, or conversely, as decided by randomization. The sham stimulation will be delivered using the reverse face of the same coil, identical in size, colour, and shape to the active one, and producing an identical sound. In addition, in both conditions, active and sham, a low-intensity transcutaneous electrical stimulation will be applied to the ipsilateral frontal muscle to mask the active stimulation. Coil orientation will be determined by a pendrive linked to the concealed randomization allocation. To ensure double-blinding, the coil will be flipped, if needed, by another operator, depending on the instructions provided when inserting the pendrive.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Active rTMS, active aiTBS, sham rTMS or sham aiTBS","The active rTMS treatment consists of 5 sessions (1 per day for 5 consecutive days), each lasting 20 minutes. Each session consists of 15 trains of 10-s pulses at 10 Hz with an inter-train interval of 50 s, delivering 1500 pulses per session for a total of 7500 pulses.\n\nThe active aiTBS treatment consists of 5 sessions delivered in a single day. Each session lasts 8 minutes, with an inter-session interval of 45 minutes and a 110-minute intervel between the third and fourth sessions. Each burst consists of 3 pulses at 50 Hz; bursts are repeated within a train of 10 bursts at 5 Hz. Each cycle consists of 2 s of train stimulation followed by 8 s of pause. One session is composed of 50 cycles, delivering 1500 pulses per session for a total of 7500 pulses.\n\nThe sham stimulation will follow the same posology and modality of administration but opposite bobine face",[9,15],null,[27,32],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},"Nadine ATTAL","CONTACT","0033149095931","nadine.attal@aphp.fr",{"name":33,"role":29,"phone":34,"phoneExt":25,"email":35},"Lorenzo Sargolini, PhD Fellow","+330743665255","lorenzo.sargolini@inserm.fr",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Hopital Ambroise-Paré INSERM U987, 9 Av. Charles de Gaulle","RECRUITING","Boulogne-Billancourt","Île-de-France Region","92100","France","FR",{"type":46,"coordinates":47},"Point",[48,49],2.24128,48.83545,{"lat":49,"lon":48},[52,55,58,60],{"name":53,"role":29,"phone":54,"phoneExt":25,"email":35},"Lorenzo Sargolini","+330149094484",{"name":56,"role":57,"phone":25,"phoneExt":25,"email":25},"Nadine Attal","PRINCIPAL_INVESTIGATOR",{"name":53,"role":59,"phone":25,"phoneExt":25,"email":25},"SUB_INVESTIGATOR",{"name":61,"role":59,"phone":25,"phoneExt":25,"email":25},"Elisa Ummarino",{"type":57,"investigatorFullName":28,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Coordinator","100641691","aitbs-and-rtms-in-neuropathic-pain-and-prediction-of-response-100641691",false,"NCT07650526","aiTBS and rTMS in Neuropathic Pain and Prediction of Response","A Double-blind, Randomized, Sham-controlled Crossover Trial Comparing the Analgesic Effects of Accelerated Intermittent Theta Burst Stimulation (aiTBS) and Classical High-frequency rTMS Targeting the Motor Cortex in Chronic Neuropathic Pain, and Prediction of Response.","TRIPP","Inclusion Criteria:\n\n1. Age over 18 years and less than 80 years\n2. Average pain intensity ≥ 4\u002F10 on the numerical scale of the Brief Pain Inventory at screening and randomization\n3. Pain present for at least 4 days per week\n4. Persistent pain for at least 6 months\n5. Stable pharmacological treatment for pain for at least 1 month prior to the study.\n6. Peripheral or central neuropathic pain (postherpetic neuralgia, painful neuropathies, nerve lesions, radiculopathy, trigeminal neuralgia, stabilized multiple sclerosis, spinal cord lesion or stroke) fulfilling criteria for probable or definite neuropathic pain; and scoring ≥ 4 out of 10 on the DN4 questionnaire\n7. Informed consent\n8. Patients who can be followed for the whole duration of the study\n9. Patients affiliated to social security in France\n\nExclusion Criteria:\n\n1. Ongoing litigation\n2. Contraindication to rTMS :\n\n   * implanted electronic devices and\u002For conductive objects near the coil: patients with an active implanted device activated or controlled by physiological signals (e.g. pacemakers, implanted cardioverter defibrillators \\[ICD\\], vagus nerve stimulators \\[VNS\\] and portable cardioverter defibrillators \\[WCD\\], ocular implants, deep 16 brain stimulation, drug chambers\u002Fpumps, intracardiac leads) even if the device has been removed.\n   * Non-removable metal objects near the coil: Patients with a conductive implant, ferromagnetic or made of any other metal sensitive to magnetic fields, in the head or at a distance of less than 30 cm from the coil (e.g. cochlear implant, implanted electrodes\u002Fpacemakers, aneurysm clips or coils, stents and bullet fragments).\n3. Current drug or psychoactive substance abuse (DSM V)\n4. Pregnancy or lactation\n5. Epilepsia or past epilepsia\n6. Progressive unsable pathology (eg cancer)\n7. Current psychosis according to DSM V criteria\n8. Presence of other pain more severe than that justifying inclusion\n9. Lack of correct completion of pain self-assessment diaries between inclusion and randomisation (at least 4 weekly pain scores over 7 days),\n10. Subject unable to understand informed consent, under guardianship or curatorship\n11. Patients participating in another research protocol within 30 days prior to inclusion.\n12. Patient who has already received a treatment with rTMS","ALL","18 Years","80 Years",{"count":76,"type":77},30,"ESTIMATED","INTERVENTIONAL",[80],"NA","This study evaluates the analgesic benefit of two non-invasive brain stimulation techniques: high frequency repetitive transcranial magnetic stimulation (rTMS) and accelerated intermittent theta burst stimulation (aiTBS) - compared to sham stimulation, in patients with chronic neuropathic pain lasting at least 6 months.\n\nTranscranial magnetic stimulation, which is delivered by a coil positioned on the scalp over the motor cortex, generates a low-intensity, submotor-threshold electromagnetic field that noninvasively activates targeted brain regions involved in pain perception. The procedure is painless and non-invasive. Sham stimulation uses the inactive face of the same coil and produces an identical sound, ensuring that neither patients nor investigators know which stimulation is being delivered.\n\nConventional rTMS has demonstrated moderate analgesic efficacy in neuropathic pain, but its effect is delayed and requires at least 5 treatment sessions. iTBS delivers the same total stimulation dose in a much shorter time (approximately 8 minutes per session versus 30 minutes for conventional rTMS) and enables accelerated protocols with multiple sessions per day, which have shown promising results in depression.\n\nThis study compares aiTBS, rTMS and sham by a randomized controlled trial (RCT) with a crossover design: participants are randomized in a 2:1 ratio to receive either active stimulation (both techniques in sequence) or sham stimulation (both techniques in sequence). Each treatment phase consists of either 5 consecutive daily rTMS sessions or 5 aiTBS sessions delivered on a single day (with a 45-min pause between sessions). The cross-over will take place after a 4 to 6-week washout period between the two active or sham treatments. The total study duration per participant is from 10 to 12 weeks, with 11-12 in-person visits.\n\nAssessments include self-reported pain diaries numeric pain rating scale (NPRS), validated pain, psychosocial, and quality-of-life questionnaires, resting-state Electroencephalography (EEG) recordings, and transcranial magnetic stimulation (TMS) based measures of intracortical excitability and inhibition. The exploratory aim is to identify neurophysiological and clinical predictors of treatment response, to better personalize the treatment in chronic pain population.",[83],"Chronic Neuropathic Pain","2026-06-30",{"date":86,"type":87},"2026-07-02","ACTUAL",{"date":89,"type":77},"2026-09",{"date":91,"type":77},"2028-09",{"name":5,"class":6},1]