[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100535895":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":58,"collaborators":60,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":10,"studyType":77,"phases":10,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":42,"whyStopped":10,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Illinois at Urbana-Champaign","OTHER",[8,14,17,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Women 1-5 years post-SG",null,"* Alcohol orally administered (0.5 grams per kg of Fat-free mass) after overnight fast or after a standard meal\n* Alcohol administered IV using an alcohol clamp (target concentration of 0.6g\u002FL after an overnight fast or one hour after consuming a standard mixed meal)",[13],"Drug: Alcohol (Ethanol)",{"label":15,"type":10,"description":11,"interventionNames":16},"Men 1-5 years post-SG",[13],{"label":18,"type":10,"description":11,"interventionNames":19},"Women, non-operated control",[13],{"label":21,"type":10,"description":11,"interventionNames":22},"Men, non-operated control",[13],[24],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"DRUG","Alcohol (Ethanol)","Alcohol given orally (0.5 grams of alcohol per kg of fat-free mass) Alcohol given iv with a clamp ( 6% v\u002Fv alcohol prepared in 0.5% normal saline). The infusion rate will exponentially increase from the start of the infusion until the target BrAC of 0.6g\u002FL (60mg%) is reached at 15 min, followed by an exponentially decreasing infusion rate, which will be tapered to a constant steady-state value to clamp the BrAC at the target value for a predetermined duration of 180 min.",[15,21,9,18],[30],{"name":31,"affiliation":5,"role":32},"Marta Y Pepino de Gruev, PhD","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":38},"Mariel Molina-Castro, BS","CONTACT","217-300-4709","marielm2@illinois.edu",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"University of Illinois at Urbana Champaign","RECRUITING","Urbana","Illinois","61801","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-88.20727,40.11059,{"lat":52,"lon":51},[55,56],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":38},{"name":57,"role":32,"phone":10,"phoneExt":10,"email":10},"Marta Y Pepino, PhD",{"type":59,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[61],{"name":62,"class":6},"Carle Foundation Hospital","100535895","alcohol-after-bariatric-surgery-2-100535895",false,"NCT06257771","Alcohol After Bariatric Surgery 2","Pharmacokinetics and Responses to Alcohol After Bariatric Surgery","ABS2","Inclusion Criteria:\n\n* Surgery groups:\n\n  * Male and female, 21-64 yrs. of age\n  * Drink at least 1 standard drink per month but no more than 7 per week (women or \\> 14 for men)\n  * Underwent SG surgery 1-5 years ago\n\nNon-surgery control group\n\n* Male and female who did not undergo bariatric surgery\n* Age , BMI, race , and alcohol pattern of consumption equivalent to participants in the SG surgery groups\n\nExclusion Criteria:\n\n* For all groups (surgery and non-surgery groups)\n\n  * Smoking or having quit smoking less than 2 months ago\n  * Pregnant or breastfeeding\n  * Taking any medications that might affect alcohol metabolism\n  * Anemia\n  * Gastritis, colitis, Crohn's Disease, malabsorptive diseases, inflammatory diseases, liver disease, kidney disease, cancer less than five years ago, stroke, or severe organ dysfunction\n  * Body weight \\>450 pounds (because of a limit on body composition machine)\n  * Alcohol use disorder\n  * Regular use of drugs with addiction potential or regular misuse of substances\n  * Abnormality on EKG as determined by a study physician to present a safety risk","ALL","21 Years","64 Years",{"count":75,"type":76},88,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn how the body processes ingested alcohol and how alcohol affects mood and blood sugar in both men and women after undergoing sleeve gastrectomy. The main question\\[s\\]it aims to answer are:\n\n* Are there differences in the way that ingested alcohol is handled in men versus women after sleeve gastrectomy?\n* What is the consequence of drinking alcohol on an empty stomach versus after a meal on blood sugar control after undergoing sleeve gastrectomy?\n\nParticipants will participate in two types of alcohol tests (alcohol given orally or administered intravenously) after not eating anything overnight or after having a meal.\n\nResearchers will compare men and women who underwent sleeve gastrectomy with men and women who had no surgery, are of similar age and body composition, and have similar alcohol intake patterns.",[80],"Sleeve Gastrectomy",[82,83,84,85],"Alcohol metabolism","Bariatric surgery","Hypoglycemia","Metabolic surgery","2025-03-07",{"date":88,"type":89},"2025-03-11","ACTUAL",{"date":91,"type":89},"2024-07-31",{"date":93,"type":76},"2028-08",{"name":5,"class":6},1]